Výsledky vyhledávání - "G. P. Mannaerts"

Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology

Autor: G P Mannaerts, Marc Fransen, Suresh Subramani, P. P. Van Veldhoven, Leen Amery

Publikováno v: Combinatorial chemistryhigh throughput screening. 4(7)

Recently, we reported the successful use of the gVI-cDNA phage display technology to clone cDNAs coding for novel peroxisomal enzymes by affinity selection using immobilized antisera directed against peroxisomal subfractions (Fransen, M.; Van Veldhov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0174b9c0aec6093e9f08d8b408712ec7
https://pubmed.ncbi.nlm.nih.gov/11669066

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Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase

Autor: K, De Nys, E, Meyhi, G P, Mannaerts, M, Fransen, P P, Van Veldhoven

Publikováno v: Biochimica et biophysica acta. 1533(1)

Based on the primary structure of the rat peroxisomal 2,4-dienoyl-CoA reductase (M. Fransen, P.P. Van Veldhoven, S. Subramani, Biochem. J. 340 (1999) 561-568), the cDNA of the human counterpart was cloned. It contained an open reading frame of 878 ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b620e3b8bbea0cfa2dd14da233293a10
https://pubmed.ncbi.nlm.nih.gov/11514237

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Fibroblast studies documenting a case of peroxisomal 2-methylacyl-CoA racemase deficiency: possible link between racemase deficiency and malabsorption and vitamin K deficiency

Autor: P P, Van Veldhoven, E, Meyhi, R H, Squires, M, Fransen, B, Fournier, V, Brys, M J, Bennett, G P, Mannaerts

Publikováno v: European journal of clinical investigation. 31(8)

2-Methylacyl-CoA racemase interconverts the 2-methyl group of pristanoyl-CoA or the 25-methyl group of hydroxylated cholestanoyl-CoAs, allowing further peroxisomal desaturation of these compounds in man by the branched chain acyl-CoA oxidase, which r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::393d81a2c5bd28825430fb71913cadad
https://pubmed.ncbi.nlm.nih.gov/11473573

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Further insights into peroxisomal lipid breakdown via alpha- and beta-oxidation

Autor: P P, Van Veldhoven, M, Casteels, G P, Mannaerts, M, Baes

Publikováno v: Biochemical Society transactions. 29(Pt 2)

Mammalian peroxisomes degrade fatty carboxylates via two pathways, beta-oxidation and, as shown more recently, alpha-oxidation. The latter process consists of an activation step, followed by a hydroxylation at position 2 and cleavage of the 2-hydroxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eca0276eb98cf4a5923004da592461f0
https://pubmed.ncbi.nlm.nih.gov/11356170

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Peroxisomal lipid degradation via beta- and alpha-oxidation in mammals

Autor: G P, Mannaerts, P P, Van Veldhoven, M, Casteels

Publikováno v: Cell biochemistry and biophysics.

Peroxisomal beta-oxidation is involved in the degradation of long chain and very long chain fatty acyl-(coenzyme A)CoAs, long chain dicarboxylyl-CoAs, the CoA esters of eicosanoids, 2-methyl-branched fatty acyl-CoAs (e.g. pristanoyl-CoA), and the CoA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::06dfbfb6ce083408c910c901e28de6bc
https://pubmed.ncbi.nlm.nih.gov/11330072

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Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse

Autor: S, Huyghe, M, Casteels, A, Janssen, L, Meulders, G P, Mannaerts, P E, Declercq, P P, Van Veldhoven, M, Baes

Publikováno v: The Biochemical journal. 353(Pt 3)

The ontogeny of the following peroxisomal metabolic pathways was evaluated in mouse liver and brain: alpha-oxidation, beta-oxidation and ether phospholipid synthesis. In mouse embryos lacking functional peroxisomes (PEX5(-/-) knock-out), a deficiency

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5fadba95cc289efa4e94ad3fddb6478
https://pubmed.ncbi.nlm.nih.gov/11171065

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Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1)

Autor: P P, Van Veldhoven, S, Gijsbers, G P, Mannaerts, J R, Vermeesch, V, Brys

Publikováno v: Biochimica et biophysica acta. 1487(2-3)

Sphingosine-1-phosphate lyase catalyzes the last step in sphingolipid breakdown, the cleavage of phosphorylated sphingoid bases such as sphingenine-1-phosphate. The latter lipid is not only a catabolite, but can influence as an inter- and/or intracel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f708a55645e091c259e770c4059df92c
https://pubmed.ncbi.nlm.nih.gov/11018465

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Hepatic alpha-oxidation of phytanic acid. A revised pathway

Autor: P P, Van Veldhoven, G P, Mannaerts, M, Casteels, K, Croes

Publikováno v: Advances in experimental medicine and biology. 466

Synthetic 3-methyl-branched chain fatty acids were used to decipher the breakdown of phytanic acid. Based on results obtained in intact or permeabilized rat hepatocytes, rat liver homogenates or subcellular fractions, a revised alpha-oxidation pathwa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac6985ce51b77551b9a4c3e32afcafab
https://pubmed.ncbi.nlm.nih.gov/10709654

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