Zobrazeno 1 - 10
of 23
pro vyhledávání: '"G. P. Gaenko"'
Publikováno v:
Russian Journal of Bioorganic Chemistry. 39:299-305
A series of N 1-acyl derivatives of 5-fluorouracil (5-FU) bearing the residues of palmitic, p-myristoylaminobenzoic, p-oleoylaminobenzoic, and adamantane-1-carboxylic acids have been synthesized. The relative hydrolysis rates for the derivatives unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e5533e7e556e5f242340841872cec20
https://doi.org/10.1134/s1068162013030138
https://doi.org/10.1134/s1068162013030138
Autor:
G. P. Gaenko, N. R. Kuznetsova, A. N. Benke, Elena L. Vodovozova, Elena V. Svirshchevskaya, I. V. Skripnik, E. N. Zarudnaya, Yu. G. Molotkovskii
Publikováno v:
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 7:12-20
When used as nanosized carriers, liposomes enable targeted delivery and decrease systemic toxicity of antitumor agents significantly. However, slow unloading of liposomes inside cells diminishes the treatment efficiency. The problem could be overcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c79365622dca3481ba7fd0daff745ed7
https://doi.org/10.1134/s1990747812050108
https://doi.org/10.1134/s1990747812050108
Autor:
E.V. Moiseeva, Nedyalko Lesev, G. P. Gaenko, Aleksey Vasilev, Julian G. Molotkovsky, Stefka Kaloyanova, Todor Deligeorgiev, Ivan A. Boldyrev
Publikováno v:
Russian Journal of Bioorganic Chemistry. 37:364-368
Cytotoxic effect of a series of 1,10-phenanthroline coordination complexes with europium tris-β-diketonate (EuCs) against HBL-100 human breast carcinoma cells was determined. Cytotoxicity of liposomal formulation of V12, the most active EuC, was als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3175ef3a971cd9dc22f31913c5700c53
https://doi.org/10.1134/s106816201103006x
https://doi.org/10.1134/s106816201103006x
Autor:
G. P. Gaenko, S. V. Khaidukov
Publikováno v:
Microbiology. 79:435-438
The inhibitory action of the lipid fraction of the extract from the spores of the anaerobic bacterium Clostridium butyricum on urokinase synthesis by the CEM line human leukemia lymphoid cells, the HBL line human breast cancer cells, and the CLL Lewi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f3887f22a8b2283b96a2961e54598f3
https://doi.org/10.1134/s002626171004003x
https://doi.org/10.1134/s002626171004003x
Publikováno v:
Microbiology. 78:580-584
Antitumor activity of the preparation of the lipid fraction of Clostridium butyricum spore extract was demonstrated in vivo on a transplantable mouse model of breast cancer. At a specific scheme of application, inhibition of tumor growth and improved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cc910d8824ca5b086efb69dd54586e7
https://doi.org/10.1134/s0026261709050087
https://doi.org/10.1134/s0026261709050087
Autor:
A.K Kandyba, G. P. Gaenko, Elena L. Vodovozova, Julian G. Molotkovsky, V. A. Kadykov, N. R. Kuznetsova, I. Vostrov
Publikováno v:
Journal of Drug Delivery Science and Technology. 19:51-59
Liposomal formulations prepared by extrusion from natural phospholipids and 1,2-dioleoylglycerol conjugates of methotrexate and melphalan (egg phosphatidylcholine-phosphatidylinositol–prodrug, 8:1:1, by mol.) were characterized by size, composition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7a1ac301a3005663c32116db152c4cc
https://doi.org/10.1016/s1773-2247(09)50007-x
https://doi.org/10.1016/s1773-2247(09)50007-x
Autor:
V. A. Kadykov, Yu. G. Molotkovsky, S. S. Khutsyan, Elena L. Vodovozova, N. R. Kuznetsova, G. P. Gaenko
Publikováno v:
Nanotechnologies in Russia. 3:228-239
The inclusion of antitumor agents into nanodimensional carriers such as 100- to 150-nm liposomes makes it possible to reduce the general toxicity of chemotherapeutic drugs by decreasing the free drug concentration in the blood flow and by increasing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::762646d503d2e475cbf351e4e812a950
https://doi.org/10.1134/s1995078008030105
https://doi.org/10.1134/s1995078008030105
Publikováno v:
Pharmaceutical Chemistry Journal. 41:297-301
A synthesis of a lipophilic derivative of methotrexate was devised, this being suitable for insertion into the membranes of carrier liposomes. The conjugate consisted of a rac-1,2-dioleoylglycerol residue attached via an ester bond to methotrexate vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d49787fb3ac2bb05437979295b662d2
https://doi.org/10.1007/s11094-007-0067-5
https://doi.org/10.1007/s11094-007-0067-5
Autor:
G. P. Gaenko, Alekhin Ai
Publikováno v:
Bulletin of Experimental Biology and Medicine. 161:412-413
Comparative culturing of mouse embryo fibroblasts on chitosan matrices and culture plastic was carried out. During the first 2 h of culturing (lag phase), cell adhesion to chitosan and chitosan-gelatin matrices was 20-30% higher than adhesion to cult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661f11bb3001ecfaeefe2f453243fed2
https://doi.org/10.1007/s10517-016-3427-x
https://doi.org/10.1007/s10517-016-3427-x
Publikováno v:
Bioorganicheskaia khimiia. 39(3)
A series of N-acyl derivatives of 5-fluorouracil (5-FU) bearing residues of palmitic, p-myristoylaminobenzoic, p-oleoylaminobenzoic, and 1-adamantanecarbonic acids was synthesized. Relative rates of hydrolysis of derivatives mentioned under physiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8247d34c30b0f7cc41e5f5148d21970
https://pubmed.ncbi.nlm.nih.gov/24397032
https://pubmed.ncbi.nlm.nih.gov/24397032