Zobrazeno 1 - 10
of 64
pro vyhledávání: '"G. P. Dotto"'
Autor:
Soumitra Ghosh, Jovan Isma, Paola Ostano, Luigi Mazzeo, Annagiada Toniolo, Monalisa Das, Joni R. White, Christian Simon, G. Paolo Dotto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Alterations in nuclear structure and function are hallmarks of cancer cells. Little is known about these changes in Cancer-Associated Fibroblasts (CAFs), crucial components of the tumor microenvironment. Loss of the androgen receptor (AR) in
Externí odkaz:
https://doaj.org/article/ecacd5c27cbc40799626a289a8be3460
Autor:
Luigi Mazzeo, Soumitra Ghosh, Emery Di Cicco, Jovan Isma, Daniele Tavernari, Anastasia Samarkina, Paola Ostano, Markus K. Youssef, Christian Simon, G. Paolo Dotto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract There are significant commonalities among several pathologies involving fibroblasts, ranging from auto-immune diseases to fibrosis and cancer. Early steps in cancer development and progression are closely linked to fibroblast senescence and
Externí odkaz:
https://doaj.org/article/339b32207a2241b58a145018d8854d9d
Autor:
Sandro Goruppi, Andrea Clocchiatti, Giulia Bottoni, Emery Di Cicco, Min Ma, Beatrice Tassone, Victor Neel, Shadhmer Demehri, Christian Simon, G. Paolo Dotto
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
The identification of kinases that control epigenetic mechanisms in squamous cell carcinomas (SCCs) can be of therapeutic relevance. Here the authors show that loss of nuclear kinase ULK3 impairs the recruitment of two histone arginine methyltransfer
Externí odkaz:
https://doaj.org/article/5292438042014403911172968fc98647
Autor:
Atul Katarkar, Giulia Bottoni, Andrea Clocchiatti, Sandro Goruppi, Pino Bordignon, Francesca Lazzaroni, Ilaria Gregnanin, Paola Ostano, Victor Neel, G. Paolo Dotto
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The presence of genomic alterations in cancer associated fibroblasts (CAFs) is largely unexplored. The authors show that frequent NOTCH1 gene amplification and overexpression render CAFs resistant to the UVA-induced DNA damage response (DDR) and prom
Externí odkaz:
https://doaj.org/article/50d8fbca5759425c9fb107d5441047f8
Autor:
Giulia Bottoni, Atul Katarkar, Beatrice Tassone, Soumitra Ghosh, Andrea Clocchiatti, Sandro Goruppi, Pino Bordignon, Paris Jafari, Fabio Tordini, Thomas Lunardi, Wolfram Hoetzenecker, Victor Neel, Joachim Lingner, G. Paolo Dotto
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Conversion of dermal fibroblasts into Cancer Associated Fibroblasts (CAFs) can play an important role in keratinocyte tumour development. Here the authors reveal that CSL plays a role in maintenance of telomeres and genomic integrity in both dermal f
Externí odkaz:
https://doaj.org/article/82b5056962d14041aae036cba6d017e3
Autor:
Sandro Goruppi, Maria-Giuseppina Procopio, Seunghee Jo, Andrea Clocchiatti, Victor Neel, G. Paolo Dotto
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2468-2479 (2017)
The connection between signaling pathways activating cancer-associated fibroblasts (CAFs) remains to be determined. Metabolic alterations linked to autophagy have also been implicated in CAF activation. CSL/RBPJ, a transcriptional repressor that medi
Externí odkaz:
https://doaj.org/article/c967984c490648ccb3d7979f68404e8a
Autor:
Pino Bordignon, Giulia Bottoni, Xiaoying Xu, Alma S. Popescu, Zinnia Truan, Emmanuella Guenova, Lukas Kofler, Paris Jafari, Paola Ostano, Martin Röcken, Victor Neel, G. Paolo Dotto
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2358-2372.e6 (2019)
Summary: Heterogeneity of cancer-associated fibroblasts (CAFs) can result from activation of distinct signaling pathways. We show that in primary human dermal fibroblasts (HDFs), fibroblast growth factor (FGF) and transforming growth factor β (TGF-
Externí odkaz:
https://doaj.org/article/16e7573a3e1445219de1a405631deb3f
Autor:
M. M. Strieder, J. I. Engelmann, R. S. Pohndorf, P. A. Rodrigues, R. S. Juliano, G. L. Dotto, L. A.A. Pinto
Publikováno v:
Grasas y Aceites, Vol 70, Iss 1, Pp e287-e287 (2019)
Refining conditions are very important to obtain high-quality rice oil. This work aimed at evaluating the effect of bleaching temperature in chemical and physical refining processes to avoid losses in γ-oryzanol and carotenoids. In addition, the asp
Externí odkaz:
https://doaj.org/article/2664a241ff034e97a295e77affcdd7a8
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3108-3114.e4 (2018)
Summary: Cancer-associated fibroblasts (CAFs) are important at all tumor stages. CSL/RBPJκ suppresses the gene expression program leading to CAF activation and associated metabolic reprogramming, as well as autophagy. Little is known about CSL prote
Externí odkaz:
https://doaj.org/article/d293074cd2c442e6904abbec55dd4060
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70392 (2013)
RORα is a retinoid-related orphan nuclear receptor that regulates inflammation, lipid metabolism, and cellular differentiation of several non-epithelial tissues. In spite of its high expression in skin epithelium, its functions in this tissue remain
Externí odkaz:
https://doaj.org/article/ab39f9db4cd247f88d9ede0e9179cd48