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PP01.25 Incidence and Timing of Immune-Related Adverse Events in Patients With Non-Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitor as Monotherapy or in Combination With Chemotherapy

Autor: A. Secor, S. Zhao, L. Wei, P. Das, T. Haddad, A. Miah, D. Spakowicz, G. Lopez, M. Husain, M. Grogan, M. Li, C. Schweitzer, C. Pilcher, D. Uribe, G. Cheng, M. Phelps, J. Guo, P. Shields, K. He, E. Bertino, D. Carbone, G. Otterson, C.J. Presley, D.H. Owen

Publikováno v: Journal of Thoracic Oncology. 18:e21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34d6e6d078ecfa83d43ce905b298ecde
https://doi.org/10.1016/j.jtho.2022.09.051

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EP08.01-098 Evaluating Risk Factors for Pneumonitis in Stage III NSCLC Patients Receiving Durvalumab after Definitive Chemoradiation

Autor: x. Mo, L. Dong, S. Patel, D. DiCostanzo, A. Alahmadi, J. Kaufman, R. Memmott, K. He, E. Bertino, C. Presley, P. Shields, G. Otterson, D.P. Carbone, M.X. Welliver, D.H. Owen

Publikováno v: Journal of Thoracic Oncology. 17:S389

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e2f0015f899a0d3393460727f62471f
https://doi.org/10.1016/j.jtho.2022.07.670

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EP08.01-062 Body Mass Index, Immune Related Adverse Events, and Survival in Patients with Metastatic Non-small Cell Lung Cancer Treated with Immunotherapy

Publikováno v: Journal of Thoracic Oncology. 17:S369

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38effed2547839ec159c59587c357873
https://doi.org/10.1016/j.jtho.2022.07.634

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Akademický článek

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Pseudomonas aeruginosaBacteremic Patients Exhibit Nonprotective Antibody Titers Against Therapeutic Antibody Targets PcrV and Psl Exopolysaccharide

Autor: M. Margarita Camara, C. Kendall Stover, Wei Zhao, Joshua T. Thaden, Antonio DiGiandomenico, Linda G. Otterson, Norah J. Shire, Vance G. Fowler, Caitlin M. Guenther, Mike Huband, Paul Warrener, Ashley E. Keller

Publikováno v: Journal of Infectious Diseases. 213:640-648

Background. The type 3 secretion protein PcrV and Psl exopolysaccharide are promising therapeutic antibody targets against Pseudomonas aeruginosa. We examined P. aeruginosa bloodstream infection (BSI) isolates for the ability to express PcrV and Psl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea8c16c68d847dab765137f9adf3040
https://doi.org/10.1093/infdis/jiv436

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Characterization of the Novel DNA Gyrase Inhibitor AZD0914: Low Resistance Potential and Lack of Cross-Resistance in Neisseria gonorrhoeae

Autor: Michael D. Huband, Humphrey Gardner, James D. Whiteaker, Linda G. Otterson, Richard A. Alm, John P. Mueller, Lisa A. Lewis, Amy Kutschke, Xiaohong Su, Robert E. McLaughlin, Sushmita D. Lahiri

Publikováno v: Antimicrobial Agents and Chemotherapy. 59:1478-1486

The unmet medical need for novel intervention strategies to treat Neisseria gonorrhoeae infections is significant and increasing, as rapidly emerging resistance in this pathogen is threatening to eliminate the currently available treatment options. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02058ede11dcc7a42cbec20e3defb676
https://doi.org/10.1128/aac.04456-14

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Microbiological interaction studies between ceftazidime-avibactam and pulmonary surfactant and between ceftazidime-avibactam and antibacterial agents of other classes

Autor: Kevin M. Krause, Michael D. Huband, Wright W. Nichols, Linda G. Otterson, John Dallow

Publikováno v: International Journal of Antimicrobial Agents. 44:552-556

For an antibacterial agent to be considered for clinical studies in nosocomial pneumonia (NP), it should be active in the presence of pulmonary surfactant. Furthermore, owing to the common practice of treating such infections with more than one antib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c518a7ca35b789771b03865ed9653e16
https://doi.org/10.1016/j.ijantimicag.2014.07.023

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Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region

Autor: Nelson B. Olivier, John Breen, Sameer Kawatkar, Satenig Guler, Linda G. Otterson, Martin F. Hentemann, James T. Loch, Gabriel Martínez-Botella, Thomas A. Keating, Andrew R. McKenzie, Oluyinka Green, Joseph V. Newman

Publikováno v: Journal of Medicinal Chemistry. 57:4584-4597

Thymidylate kinase (TMK), an essential enzyme in bacterial DNA biosynthesis, is an attractive therapeutic target for the development of novel antibacterial agents, and we continue to explore TMK inhibitors with improved potency, protein binding, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8b94a064a6fe01328d844cf79367be
https://doi.org/10.1021/jm500463c

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Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)

Autor: Amy Kutschke, Gunther Kern, Peter Doig, Vincent Galullo, Gregory S. Basarab, Madhusudhan Reddy Gowravaram, Fei Zhou, Karthick Vishwanathan, Linda G. Otterson, Amy Kimzey, Marshall Morningstar, John P. Mueller, Joseph P. Newman

Publikováno v: Journal of medicinal chemistry. 58(15)

A novel class of bacterial type-II topoisomerase inhibitor displaying a spiropyrimidinetrione architecture fused to a benzisoxazole scaffold shows potent activity against Gram-positive and fastidious Gram-negative bacteria. Here, we describe a series

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e95c201ff7e1c01611e1d2f11eaf29
https://pubmed.ncbi.nlm.nih.gov/26158756

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