Zobrazeno 1 - 10
of 76
pro vyhledávání: '"G. Oser"'
Autor:
Hsiao-Yun Chen, Yavuz T. Durmaz, Yixiang Li, Amin H. Sabet, Amir Vajdi, Thomas Denize, Emily Walton, Yasmin Nabil Laimon, John G. Doench, Navin R. Mahadevan, Julie-Aurore Losman, David A. Barbie, Michael Y. Tolstorukov, Charles M. Rudin, Triparna Sen, Sabina Signoretti, Matthew G. Oser
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
LSD1 inhibition blocks the neuroendocrine phenotype of some small cell lung cancers (SCLCs). Here, a genome-wide CRISPR/Cas9 LSD1 inhibitor resistance screen identifies the mRNA-binding protein ZFP36L1 as a gene repressed by LSD1 that when restored i
Externí odkaz:
https://doaj.org/article/7672bb9231c144b3a01d9383ed50542c
Autor:
William G. Kaelin, Simon T. Barry, Christopher J. Lord, Susan Ashton, David Pellman, Sabina Signoretti, David E. Root, Jon Travers, Kim Maratea, Elizabeth J. Pease, Colm J. Ryan, Stefano Cairo, Paula Taylor, Laura Brulle-Soumare, Quang-De Nguyen, Dennis M. Bonal, Glenn S. Cowley, Samuel K. McBrayer, Scott T. Younger, Elizabeth Buss, Aditi Gulati, Jesse S. Novak, Abdallah Flaifel, Rebecca B. Jennings, Alexander Spektor, Rachel Brough, Abhishek A. Chakraborty, Raquel Fonseca, Matthew G. Oser
Supplementary Table S2 shows Raw NGS reads and Log2 Norm Scores from Illumina sequencing of the pRB synthetic lethal screen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a458a7799f1c29f96364db5b253ee2d
https://doi.org/10.1158/2159-8290.22533016
https://doi.org/10.1158/2159-8290.22533016
Autor:
William G. Kaelin, Simon T. Barry, Christopher J. Lord, Susan Ashton, David Pellman, Sabina Signoretti, David E. Root, Jon Travers, Kim Maratea, Elizabeth J. Pease, Colm J. Ryan, Stefano Cairo, Paula Taylor, Laura Brulle-Soumare, Quang-De Nguyen, Dennis M. Bonal, Glenn S. Cowley, Samuel K. McBrayer, Scott T. Younger, Elizabeth Buss, Aditi Gulati, Jesse S. Novak, Abdallah Flaifel, Rebecca B. Jennings, Alexander Spektor, Rachel Brough, Abhishek A. Chakraborty, Raquel Fonseca, Matthew G. Oser
This document contains the text for the supplementary data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5732b09751dfedc3f31258a710153e32
https://doi.org/10.1158/2159-8290.22533001
https://doi.org/10.1158/2159-8290.22533001
Autor:
William G. Kaelin, Simon T. Barry, Christopher J. Lord, Susan Ashton, David Pellman, Sabina Signoretti, David E. Root, Jon Travers, Kim Maratea, Elizabeth J. Pease, Colm J. Ryan, Stefano Cairo, Paula Taylor, Laura Brulle-Soumare, Quang-De Nguyen, Dennis M. Bonal, Glenn S. Cowley, Samuel K. McBrayer, Scott T. Younger, Elizabeth Buss, Aditi Gulati, Jesse S. Novak, Abdallah Flaifel, Rebecca B. Jennings, Alexander Spektor, Rachel Brough, Abhishek A. Chakraborty, Raquel Fonseca, Matthew G. Oser
Supplementary Figure S1 shows RB1 is synthetic lethal with multiple genes that regulate chromosomal segregation. Supplementary Figure S2 shows genetic inactivation of AURKB is synthetic lethal with RB1 loss in NCI-H82 cells. Supplementary Figure S3 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9edcc3ee48d8078c48fd9b3d57494e
https://doi.org/10.1158/2159-8290.22533022
https://doi.org/10.1158/2159-8290.22533022
Autor:
David A. Barbie, Matthew G. Oser, Ellis L. Reinherz, Scott Rodig, Robin Edwards, Evisa Gjini, Pasi A. Jänne, Kathleen Pfaff, Michael Y. Tolstorukov, Lynette M. Sholl, Fangxin Hong, Benjamin Chen, Xi-Tao Wang, Ana Lako, Eliezer M. Van Allen, Mark M. Awad, Cloud P. Paweletz, Prafulla C. Gokhale, Brendan Reardon, Hideo Watanabe, Maya Fridrikh, Aoi Akitsu, Shunsuke Kitajima, Israel Cañadas, Takahiko Murayama, Alison D. Santucci, Victor Quadros, Andrew Portell, Patrick H. Lizotte, Luke J. Taus, Michael J. Poitras, Jonathan S. Duke-Cohan, Bruce B. Reinhold, Saemi Han, Brandon Piel, Tran C. Thai, Deli Hong, Marco Campisi, Maria Saigí, Amir Vajdi, Jacquelyn O. Wolff, Erik H. Knelson, Navin R. Mahadevan
Small cell lung carcinoma (SCLC) is highly mutated, yet durable response to immune checkpoint blockade (ICB) is rare. SCLC also exhibits cellular plasticity, which could influence its immunobiology. Here we discover that a distinct subset of SCLC uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4647caa0d1c61ca9a140b00973df6824
https://doi.org/10.1158/2159-8290.c.6549244.v1
https://doi.org/10.1158/2159-8290.c.6549244.v1
Autor:
David A. Barbie, Matthew G. Oser, Ellis L. Reinherz, Scott Rodig, Robin Edwards, Evisa Gjini, Pasi A. Jänne, Kathleen Pfaff, Michael Y. Tolstorukov, Lynette M. Sholl, Fangxin Hong, Benjamin Chen, Xi-Tao Wang, Ana Lako, Eliezer M. Van Allen, Mark M. Awad, Cloud P. Paweletz, Prafulla C. Gokhale, Brendan Reardon, Hideo Watanabe, Maya Fridrikh, Aoi Akitsu, Shunsuke Kitajima, Israel Cañadas, Takahiko Murayama, Alison D. Santucci, Victor Quadros, Andrew Portell, Patrick H. Lizotte, Luke J. Taus, Michael J. Poitras, Jonathan S. Duke-Cohan, Bruce B. Reinhold, Saemi Han, Brandon Piel, Tran C. Thai, Deli Hong, Marco Campisi, Maria Saigí, Amir Vajdi, Jacquelyn O. Wolff, Erik H. Knelson, Navin R. Mahadevan
Supplementary Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdb01871ac4703e7fdf6229583a3de7
https://doi.org/10.1158/2159-8290.22540003.v1
https://doi.org/10.1158/2159-8290.22540003.v1
Autor:
David A. Barbie, Matthew G. Oser, Ellis L. Reinherz, Scott Rodig, Robin Edwards, Evisa Gjini, Pasi A. Jänne, Kathleen Pfaff, Michael Y. Tolstorukov, Lynette M. Sholl, Fangxin Hong, Benjamin Chen, Xi-Tao Wang, Ana Lako, Eliezer M. Van Allen, Mark M. Awad, Cloud P. Paweletz, Prafulla C. Gokhale, Brendan Reardon, Hideo Watanabe, Maya Fridrikh, Aoi Akitsu, Shunsuke Kitajima, Israel Cañadas, Takahiko Murayama, Alison D. Santucci, Victor Quadros, Andrew Portell, Patrick H. Lizotte, Luke J. Taus, Michael J. Poitras, Jonathan S. Duke-Cohan, Bruce B. Reinhold, Saemi Han, Brandon Piel, Tran C. Thai, Deli Hong, Marco Campisi, Maria Saigí, Amir Vajdi, Jacquelyn O. Wolff, Erik H. Knelson, Navin R. Mahadevan
Supplementary Figures 1-12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219fb0a74b9ede1ef293c6a7f98f274e
https://doi.org/10.1158/2159-8290.22540006.v1
https://doi.org/10.1158/2159-8290.22540006.v1
Autor:
Yavuz T Durmaz, Amin H Sabet, Deli Hong, Anna C. Schinzel, Emily Walton, Kristen L Jones, Maura Sticco-Ivins, Yixiang Li, Quang-Dé Nguyen, Roderick T. Bronson, Sabina Signoretti, Tran C. Thai, Erik H. Knelson, David A. Barbie, Amir Vajdi, Matthew G. Oser, Wenhua Gao, Michael Y. Tolstorukov, Marina Vivero
Publikováno v:
Cancer Res
Neuroendocrine to nonneuroendocrine plasticity supports small cell lung cancer (SCLC) tumorigenesis and promotes immunogenicity. Approximately 20% to 25% of SCLCs harbor loss-of-function (LOF) NOTCH mutations. Previous studies demonstrated that NOTCH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76b2001f3efd08fba2be97d35f7f62c
https://doi.org/10.1158/0008-5472.can-21-1991
https://doi.org/10.1158/0008-5472.can-21-1991
Autor:
Matthew G. Oser, David A. Barbie, Sabina Signoretti, Marina Vivero, Michael Y. Tolstorukov, Quang-De Nguyen, Rod T. Bronson, Anna C. Schinzel, Kristen L. Jones, Amin H. Sabet, Maura Sticco-Ivins, Tran Thai, Amir Vajdi, Emily Walton, Wenhua Gao, Yavuz T. Durmaz, Yixiang Li, Erik H. Knelson, Deli Hong
LISA analysis of master regulators of differentially expressed genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2e0afea43a55eb4f82c0b308eb6ff3
https://doi.org/10.1158/0008-5472.22430877.v1
https://doi.org/10.1158/0008-5472.22430877.v1
Autor:
Matthew G. Oser, David A. Barbie, Sabina Signoretti, Marina Vivero, Michael Y. Tolstorukov, Quang-De Nguyen, Rod T. Bronson, Anna C. Schinzel, Kristen L. Jones, Amin H. Sabet, Maura Sticco-Ivins, Tran Thai, Amir Vajdi, Emily Walton, Wenhua Gao, Yavuz T. Durmaz, Yixiang Li, Erik H. Knelson, Deli Hong
Supplementary Data including supplementary methods, supplementary figures, and supplementary figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c27f5265eb03db7b6619e30e87e197
https://doi.org/10.1158/0008-5472.22430895.v1
https://doi.org/10.1158/0008-5472.22430895.v1