No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice

Autor: Veslemøy Rolseth, Luisa Luna, Ann Karin Olsen, Rajikala Suganthan, Katja Scheffler, Christine G. Neurauter, Ying Esbensen, Anna Kuśnierczyk, Gunn A. Hildrestrand, Anne Graupner, Jill M. Andersen, Geir Slupphaug, Arne Klungland, Hilde Nilsen, Magnar Bjørås

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Abstract Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the first step of BER. The

Externí odkaz: https://doaj.org/article/5c917068e02c43e0970c726380db6068

Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice

Autor: Lars Eide, Magnar Bjørås, Kirsten Krohg-Sørensen, Göran K. Hansson, Lasse Folkersen, Daniel F. J. Ketelhuth, Rolf K. Berge, Ingunn Østlie, Bodil Bjørndal, Ulf Hedin, Jeroen J. T. Otten, Tuva B. Dahl, Erik A.L. Biessen, Rajikala Suganthan, Gunn A. Hildrestrand, Per Ole Iversen, Geir Slupphaug, Thor Ueland, Katja Scheffler, Sverre Holm, Asbjørn Svardal, Tonje Skarpengland, Anna Kuśnierczyk, Pål Aukrust, Ole Kristoffer Olstad, Anna M. Lundberg, Christine G. Neurauter, Ståle Nygård, Mona Skjelland, Ida Gregersen, Luisa Luna, Bente Halvorsen, Filip M. Segers

Publikováno v: Scientific Reports
Skarpengland, T, Holm, S, Scheffler, K, Gregersen, I, Dahl, T B, Suganthan, R, Segers, F M, Østlie, I, Otten, J J T, Luna, L, Ketelhuth, D F J, Lundberg, A M, Neurauter, C G, Hildrestrand, G, Skjelland, M, Bjørndal, B, Svardal, A M, Iversen, P O, Hedin, U, Nygård, S, Olstad, O K, Krohg-Sorensen, K, Slupphaug, G, Eide, L, Kusnierczyk, A, Folkersen, L, Ueland, T, Berge, R K, Hansson, G K, Biessen, E A L, Halvorsen, B, Bjørås, M & Aukrust, P 2016, ' Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice ', Scientific Reports, vol. 6, 28337 . https://doi.org/10.1038/srep28337
Scientific Reports, 6:28337. Nature Publishing Group
6:28337

Increasing evidence suggests that oxidative DNA damage accumulates in atherosclerosis. Recently, we showed that a genetic variant in the human DNA repair enzyme NEIL3 was associated with increased risk of myocardial infarction. Here, we explored the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd5f302470f2ca60765cbd393083f4f

Interferon-γ-Induced Conversion of Tryptophan: Immunologic and Neuropsychiatric Aspects

Autor: Dietmar Fuchs, Katharina Schröcksnadel, G. Neurauter, Barbara Frick, Barbara Wirleitner

Publikováno v: Current Medicinal Chemistry. 10:1581-1591

Tryptophan is an essential amino acid and the least abundant constituent of proteins. In parallel it represents a source for two important biochemical pathways: the generation of neurotransmitter 5-hydroxytryptamine (serotonin) by the tetrahydrobiopt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8eb3f763ddd8ce9b01f9fdc5511b898
https://doi.org/10.2174/0929867033457179

Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia

Autor: Veslemøy Rolseth, Cynthia J. Burrows, Rajikala Suganthan, David Kunke, Ola Didrik Saugstad, Gunn A. Hildrestrand, Christine G. Neurauter, Aaron M. Fleming, Luisa Luna, Yngve Sejersted, Monica Atneosen-Åsegg, Silje Zandstra Krokeide, Magnar Bjørås

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 108(46)

Neural stem/progenitor cell proliferation and differentiation are required to replace damaged neurons and regain brain function after hypoxic-ischemic events. DNA base lesions accumulating during hypoxic-ischemic stress are removed by DNA glycosylase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d201fc4c8f8c674ea4e0d2fc215214
https://pubmed.ncbi.nlm.nih.gov/22065741

Expression patterns of Neil3 during embryonic brain development and neoplasia

Autor: Christine G. Neurauter, Stefan Krauss, Gunn A. Hildrestrand, Dzung B. Diep, Luisa Luna, Cesilie Granum Castellanos, Magnar Bjørås

Publikováno v: BMC Neuroscience
BMC Neuroscience, Vol 10, Iss 1, p 45 (2009)

Background The base excision repair pathway is responsible for repairing small DNA base lesions caused by endogenous and exogenous damaging agents. Repair is initiated by DNA glycosylases that recognize and remove the lesions. NEIL3 is one of 11 mamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f42f1e0dcb245d9fac0c9173883bb5
https://pubmed.ncbi.nlm.nih.gov/19426544