The Neuroprotective Effect of N-Docosahexaenoyldopamine on Degenerating Dopaminergic Neurons of the Mesencephalon

Autor: A. I. Sturova, G. N. Zinchenko, E. R. Mingazov, Natalia Gretskaya, V. E. Blokhin, Michael V. Ugrumov, Vladimir V. Bezuglov, S. A. Surkov

Publikováno v: Biology Bulletin. 47:466-473

This study was aimed at evaluating the neuroprotective effect of N-docosahexaenoyldopamine (DHA-DA), an endogenous bioactive lipid of the neurolipin family, on mesencephalic dopaminergic neurons of mouse fetuses in a cell culture under exposure to 1-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::964ef9c836456ae8f9adbb0c1d2db446
https://doi.org/10.1134/s1062359020050106

GPR55 Receptor Activation by the N-acyl Dopamine Family Lipids Induces Apoptosis in Cancer Cells via the Nitric Oxide Synthase (nNOS) Over-Stimulation

Autor: Polina V Dudina, Alina M. Gamisonia, Anastasia A Gaydaryova, M. G. Akimov, G. N. Zinchenko, Andrey S. Kuznetsov, Vladimir V. Bezuglov, Natalia Gretskaya

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 2
International Journal of Molecular Sciences, Vol 22, Iss 622, p 622 (2021)

GPR55 is a GPCR of the non-CB1/CB2 cannabinoid receptor family, which is activated by lysophosphatidylinositol (LPI) and stimulates the proliferation of cancer cells. Anandamide, a bioactive lipid endocannabinoid, acts as a biased agonist of GPR55 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d00bd96d4256e1e13779a2d440fd8e

The effects of neurolipins and their synthetic analogues on normal and transformed glial cells

Autor: Igor V. Serkov, M. Yu. Bobrov, G. N. Zinchenko, Fomina-Ageeva Ev, Natalia Gretskaya, Vladimir V. Bezuglov, E. L. Andrianova

Publikováno v: Neurochemical Journal. 4:46-54

In this work, we studied the effects of endogenous and synthetic derivatives of polyunsaturated fatty acids (neurolipins) on the viability of cells of rat C6 glioma and human U251 glioma cells. We synthesized 46 analogues of endogenous substances, am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ef08c8712f0c6548c9fb23d3b942a2d
https://doi.org/10.1134/s1819712410010095

Nanocomplexes of recombinant proteins and polysialic acid: Preparation, characteristics, and biological activity

Autor: M. G. Akimov, E. D. Shibanova, D. I. Bairamashvili, G. N. Zinchenko, M. Yu. Bobrov, Fomina-Ageeva Ev, Vladimir V. Bezuglov, Dmitry V. Klinov, Anatoly I. Miroshnikov, Natalia Gretskaya

Publikováno v: Russian Journal of Bioorganic Chemistry. 35:320-325

A preparation of nanocomplexes containing recombinant proteins (interferons alpha2b and beta1b, insulin, and human granulocyte colony stimulating factor) and natural polysialic acid (PSA) has been described. The incorporation of protein into the comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38216d38328b6424c64c682017306f0c
https://doi.org/10.1134/s1068162009030066

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Autor: G. A. Buznikov, L. A. Nikitina, G. N. Zinchenko, Vladimir V. Bezuglov

Publikováno v: Russian Journal of Bioorganic Chemistry. 27:200-203

Choline and N,N-dimethylaminoethyl esters of arachidonic and some other fatty acids were synthesized. Experiments on the embryos and larvae of sea urchins, sensitive to cholinergic compounds, showed that arachidonoylcholine exhibited cholinomimetic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9648a67d495e8ce6decf3b67338324f
https://doi.org/10.1023/a:1011341623358