Výsledky vyhledávání - "G. N. Henderson"

A Controlled Clinical Trial of Dichloroacetate for Treatment of Lactic Acidosis in Adults

Autor: Jenkinson S, Baumgartner Tg, Bersin Rm, E. C. Wright, G. N. Henderson, S. H. Curry, Charles A. Duncan, Buchalter S, Harman Em, Peter W. Stacpoole

Publikováno v: New England Journal of Medicine. 327:1564-1569

Background. Mortality is very high in lactic acidosis, and there is no satisfactory treatment other than treatment of the underlying cause. Uncontrolled studies have suggested that dichloroacetate, which stimulates the oxidation of lactate to acetyl-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3341b797215387346808d07fd68ba663
https://doi.org/10.1056/nejm199211263272204

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Pharmacokinetics and metabolism of [14C]dichloroacetate in male Sprague-Dawley rats. Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate

Autor: M O, James, Z, Yan, R, Cornett, V M, Jayanti, G N, Henderson, N, Davydova, M J, Katovich, B, Pollock, P W, Stacpoole

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 26(11)

Pathways of metabolism of dichloroacetate (DCA), an investigational drug for the treatment of lactic acidosis in humans and a rodent hepatocarcinogen, are poorly understood. In this study, rats were given, by gavage, one or two 50 mg/kg doses of NaDC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2738011abb5bb3808c7075de625cc6cd
https://pubmed.ncbi.nlm.nih.gov/9806957

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Glutathione-dependent conversion to glyoxylate, a major pathway of dichloroacetate biotransformation in hepatic cytosol from humans and rats, is reduced in dichloroacetate-treated rats

Autor: M O, James, R, Cornett, Z, Yan, G N, Henderson, P W, Stacpoole

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 25(11)

Although it has been postulated that glyoxylate is an intermediate in the biotransformation of DCA to oxalate, CO2, and glycine, there has been no positive identification of glyoxylate as a metabolite of DCA. We have demonstrated that a GSH-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3d920ef23f8c56b8b2149f967a799346
https://pubmed.ncbi.nlm.nih.gov/9351896

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Natural history and course of acquired lactic acidosis in adults. DCA-Lactic Acidosis Study Group

Autor: P W, Stacpoole, E C, Wright, T G, Baumgartner, R M, Bersin, S, Buchalter, S H, Curry, C, Duncan, E M, Harman, G N, Henderson, S, Jenkinson

Publikováno v: The American journal of medicine. 97(1)

To determine the pathogenesis and clinical course of lactic acidosis in adults receiving standard medical care.Placebo arm of a 5-year prospective, randomized, blinded study comparing placebo and dichloroacetate as specific lactate-lowering therapy.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3be3b09ab54cb42254654365272feeef
https://pubmed.ncbi.nlm.nih.gov/8030656

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A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group

Autor: P W, Stacpoole, E C, Wright, T G, Baumgartner, R M, Bersin, S, Buchalter, S H, Curry, C A, Duncan, E M, Harman, G N, Henderson, S, Jenkinson

Publikováno v: The New England journal of medicine. 327(22)

Mortality is very high in lactic acidosis, and there is no satisfactory treatment other than treatment of the underlying cause. Uncontrolled studies have suggested that dichloroacetate, which stimulates the oxidation of lactate to acetyl-coenzyme A a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc1f2a6cdd26104b49106b8763755147
https://pubmed.ncbi.nlm.nih.gov/1435883

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Semiconductor Ballistic Electron Reflection, Refraction, Interference, and Diffraction Effects: Modeling and Quantum Device Applications

Autor: T. K. Gaylord, G. N. Henderson, E. N. Glytsis, D. W. Wilson, P. N. First, D. B. Walker

Publikováno v: Integrated Photonics Research.

Semiconductor growth techniques such as molecular beam epitaxy have been refined so that nanostructures can be grown with precise monolayer and compositional control [1]. This has produced semiconductor materials in which ballistic (collisionless) el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::365f11ba1b0633ccc04e94c122504a75
https://doi.org/10.1364/ipr.1992.tue5

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Preparation and stability of intravenous solutions of sodium dichloroacetate (DCA)

Autor: P I, Chu, S H, Curry, T G, Baumgartner, G N, Henderson, P W, Stacpoole

Publikováno v: Journal of parenteral science and technology : a publication of the Parenteral Drug Association. 46(1)

An IV injection formulation of sodium dichloroacetate (DCA) was prepared without heat sterilization, and examined for stability. DCA is heat labile in aqueous solutions. Its decomposition involves dehalogenation and production of hydrogen ions. Decom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d18817b36a3205a775c5a1b254d4de6
https://pubmed.ncbi.nlm.nih.gov/1625103

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