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Akademický článek

G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo

Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 1, Pp 22-31 (2017)

Abstract Intronic GGGGCC repeat expansions in C9orf72 are the most common known cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), which are characterised by degeneration of cortical and motor neurons, respectively. Repea

Externí odkaz: https://doaj.org/article/1f8b61ee6cea4757929c90eeb5c2d015

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Akademický článek

Specific biomarkers for C9orf72 FTD/ALS could expedite the journey towards effective therapies

Autor: Rubika Balendra, Thomas G Moens, Adrian M Isaacs

Publikováno v: EMBO Molecular Medicine, Vol 9, Iss 7, Pp 853-855 (2017)

Abstract A hexanucleotide repeat expansion in the C9orf72 gene is a common genetic cause of ALS and FTD. The repeats are translated into five different dipeptide repeat proteins (DPRs). In this issue, Lehmer et al (2017) demonstrate that one of these

Externí odkaz: https://doaj.org/article/b3b988c8104142edb72bd52afb5a17e9

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Akademický článek

Aesthetic Experience in Virtual Museums: A Postphenomenological Perspective

Autor: Bart G. Moens

Publikováno v: Studies in Digital Heritage, Vol 2, Iss 1 (2018)

This article explores the impact of the digitization of traditional works of art on the aesthetic experience from a philosophical point of view. Presenting and making use of a recent approach in the philosophy of technology, initiated by the American

Externí odkaz: https://doaj.org/article/7ff425a685de45e2975ee70541e07c07

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Akademický článek

A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology

Autor: Mar Matarin, Dervis A. Salih, Marina Yasvoina, Damian M. Cummings, Sebastian Guelfi, Wenfei Liu, Muzammil A. Nahaboo Solim, Thomas G. Moens, Rocio Moreno Paublete, Shabinah S. Ali, Marina Perona, Roshni Desai, Kenneth J. Smith, Judy Latcham, Michael Fulleylove, Jill C. Richardson, John Hardy, Frances A. Edwards

Publikováno v: Cell Reports, Vol 10, Iss 4, Pp 633-644 (2015)

We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of “amyloid” transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and “TAU” transgenic mice (mutant human MAPT gene). Micr

Externí odkaz: https://doaj.org/article/0334cf3976634ae2a36a01bc25cb4353

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Composing ‘the artistic projection of the future’: the religious life model slide sets of Maison de la Bonne Presse

Autor: Bart G. Moens

Publikováno v: Early Popular Visual Culture. 18:255-282

With its sequences of projected images, accompanied by narration and often by music, the optical lantern as a communication medium proved to be effective for Christian evangelism, especially throug...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e1178b23de3aea9d5a809058b9b9c6b
https://doi.org/10.1080/17460654.2021.1925941

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C21orf2 mutations found in ALS disrupt primary cilia function

Autor: Mathias De Decker, Pavol Zelina, Thomas G Moens, Kristel Eggermont, Matthieu Moisse, Jan H. Veldink, Ludo Van Den Bosch, R. Jeroen Pasterkamp, Philip Van Damme

SUMMARYAmyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease that affects 1 in 400 people. Almost 40 genes have been associated with ALS, currently explaining about 15% of the ALS risk. These genes tend to cluster

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77cced94e91ff4ab81ee5abbec8a20a2
https://doi.org/10.1101/2022.02.28.482239

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Respiratory onset of amyotrophic lateral sclerosis in a pregnant woman with a novel SOD1 mutation

Autor: Pegah Masrori, Simona Ospitalieri, Karin Forsberg, Thomas G. Moens, Koen Poesen, Valerie Race, Thomas Brännström, Peter M. Andersen, Dietmar R. Thal, Philip Van Damme

BACKGROUND AND PURPOSE: With the advent of gene therapies for amyotrophic lateral sclerosis (ALS), the importance of gene testing in ALS is increasing. This will likely lead to the identification of new variants for which the pathogenicity is not est

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9284713d79c9c18adc9b7148d95ae1bf
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193155

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