Zobrazeno 1 - 10 of 179 pro vyhledávání: '"G. Michael Blackburn"'
1
Elektronická kniha
Nucleic Acids in Chemistry and Biology
Autor: G Michael Blackburn, Martin Egli, Michael J Gait, Jonathan K Watts
The structure, function and reactions of nucleic acids are central to molecular biology and medicine and are crucial for understanding of the ever-expanding range of complex biological processes involved which are central to life. Revised, extended,
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2
Nucleosides and Nucleotides
Autor: David M. Williams, G. Michael Blackburn
Publikováno v: Nucleic Acids in Chemistry and Biology ISBN: 9781788019040
In this chapter we describe methods for the chemical synthesis of modified nucleosides and nucleotides. Because most naturally nucleosides and nucleotides are commercially available, syntheses have been directed at the generation of nucleosides conta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c03322cbb3508e3bafe4baecf8a71c72
https://doi.org/10.1039/9781837671328-00096
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3
Introduction and Overview
Autor: G. Michael Blackburn, Martin Egli, Michael J. Gait, Jonathan K. Watts
Publikováno v: Nucleic Acids in Chemistry and Biology ISBN: 9781788019040
For over 60 years, we have been fascinated and stimulated by their awareness that the study of nucleic acids is central to the knowledge of life. This chapter looks at the biological importance of DNA, the origins of nucleic acids research, early str
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5386a15a3211d01178a7caa2edfbc186
https://doi.org/10.1039/9781837671328-00001
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4
Covalent Modifications of Nucleic Acids and Their Repair
Autor: G. Michael Blackburn
Publikováno v: Nucleic Acids in Chemistry and Biology ISBN: 9781788019040
The main DNA repair processes in humans involve direct repair (DR), base excision repair (BER), nucleotide excision repair (NER), interstrand crosslink repair (ICR) and base mismatch repair (BMR), as have been described in other chapters, in addition
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6a7185fd46203aac96633d084d8d716
https://doi.org/10.1039/9781837671328-00421
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5
Octahedral Trifluoromagnesate, an Anomalous Metal Fluoride Species, Stabilizes the Transition State in a Biological Motor
Autor: Alfred A. Antson, Robert W. Molt, Yi Jin, Mengyu Ge, Huw T. Jenkins, G. Michael Blackburn
Publikováno v: Ge, M, Robert W., M J, Jenkins, H T, Blackburn, G M, Jin, Y & Antson, A A 2021, ' Octahedral Trifluoromagnesate, an Anomalous Metal Fluoride Species, Stabilizes the Transition State in a Biological Motor ', ACS Catalysis, vol. 11, no. 5, pp. 2769-2773 . https://doi.org/https://pubs.acs.org/doi/10.1021/acscatal.0c04500
ACS Catalysis
Isoelectronic metal fluoride transition state analogue (TSA) complexes, MgF3– and AlF4–, have proven to be immensely useful in understanding mechanisms of biological motors utilizing phosphoryl transfer. Here we report a previously unobserved oct
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ce65cad7d20401e72976982a5985f6
https://research.manchester.ac.uk/en/publications/f881039e-1c3b-4f25-a60e-d3fab12fbf32
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7
Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers
Autor: Alexey A. Belogurov, Spyros D. Chatziefthimiou, Richard A. Lerner, Ekaterina Round, Yuliana A. Mokrushina, T. V. Bobik, Alexander G. Gabibov, Anastasia V. Stepanova, Andrey V. Golovin, G. Michael Blackburn, Gleb Bourenkov, Matthias Wilmanns, Alexander Zlobin, O. G. Shamborant, Ivan V. Smirnov, Alexey Stepanov, Kirill A. Konovalov, Arthur O. Zalevsky, Stanislav S. Terekhov, Sofiya O. Pipiya, Jia Xie, Alexander A. Makarov
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 117(37), 22841-22848 (2020). doi:10.1073/pnas.2010317117
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 117(37), 22841 - 22848 (2020). doi:10.1073/pnas.2010317117
Quantum mechanics/molecular mechanics (QM/MM) maturation of an immunoglobulin (Ig) powered by supercomputa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8487a01b9207d346e1a8894bad052d84
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8
Assessing the Influence of Mutation on GTPase Transition States by Using X‐ray Crystallography, 19 F NMR, and DFT Approaches
Autor: Yi Jin, Robert W. Molt, Erika Pellegrini, Matthew J. Cliff, Matthew W. Bowler, Nigel G. J. Richards, G. Michael Blackburn, Jonathan P. Waltho
Publikováno v: Angewandte Chemie (International Ed. in English)
We report X‐ray crystallographic and 19F NMR studies of the G‐protein RhoA complexed with MgF3 −, GDP, and RhoGAP, which has the mutation Arg85′Ala. When combined with DFT calculations, these data permit the identification of changes in trans
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdf48d32cbd3b9ac4c67e1a5ad966f0
https://doi.org/10.1002/ange.201703074
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10
van der Waals contact between nucleophile and transferring phosphorus is insufficient to achieve enzyme transition state architecture
Autor: Matthew W. Bowler, Luke A. Johnson, Yi Jin, Clare R. Trevitt, Angus J. Robertson, Nicola J. Baxter, Henry P. Wood, G. Michael Blackburn, Matthew J. Cliff, Jonathan P. Waltho, Claudine Bisson, Andrea M. Hounslow
Publikováno v: Johnson, L A, Robertson, A J, Baxter, N, Trevitt, C R, Bisson, C, Jin, Y, Wood, H P, Hounslow, A M, Cliff, M, Blackburn, G M, Bowler, M W & Waltho, J 2018, ' van der Waals contact between nucleophile and transferring phosphorus is insufficient to achieve enzyme transition state architecture ', ACS Catalysis, vol. 8, no. 9 . https://doi.org/10.1021/acscatal.8b01612
Phosphate plays a crucial role in biology because of the stability of the phosphate ester bond. To overcome this inherent stability, enzymes that catalyze phosphoryl transfer reactions achieve enormous rate accelerations to operate on biologically re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d86eef35bdcd6633761ee9f7e3f346
https://www.research.manchester.ac.uk/portal/en/publications/van-der-waals-contact-between-nucleophile-and-transferring-phosphorus-is-insufficient-to-achieve-enzyme-transition-state-architecture(74deb64c-0de8-4382-8d43-a537a19a4c89).html
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