Zobrazeno 1 - 10
of 188
pro vyhledávání: '"G. Menke"'
Autor:
Olga Price, Brian K. Hubbard, Ching H. Chang, Carl P. Sparrow, Jiyan Xue, Richard Raubertas, Silvi Luell, Xiaoli Ping, Alison M. Strack, Anil Thankappan, Gary P. O'Neill, Tsuei-Ju Wu, Xinchun Tong, Charlotte Burton, John G. Menke, Lesley Mcnamara, Sheng-Ping Wang, Emanuel Zycband, Jing Chen, John Woods, Douglas W. Kawka, Ester Carballo-Jane, M. Gerard Waters, Michele Mariano, Ayesha Sitlani, Michael Wolff
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 1, Pp 177-188 (2013)
The use of nicotinic acid to treat dyslipidemia is limited by induction of a "flushing" response, mediated in part by the interaction of prostaglandin D(2) (PGD(2)) with its G-protein coupled receptor, DP1 (Ptgdr). The impact of DP1 blockade (genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6094b0f49fedf43cf3350ecf126bf4f2
http://www.sciencedirect.com/science/article/pii/S0022227520417729
http://www.sciencedirect.com/science/article/pii/S0022227520417729
Autor:
Minal Patel, Grace M. Quaker, Hyun O. Ok, Lin Chu, Amy Galka, Annie Zhao, Jane Lo, Heather L. Sings, Jisong Cui, Amy F. Cheng, Lawrence F. Colwell, Stephanie L. Witkin, Feroze Ujjainwalla, John G. Menke, Debra Ondeyka, Helen M. Armstrong, Linda L. Chang, Nancy S. Hayes, Jilly F. Evans, Mark T. Goulet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4133-4138
A search for a suitable replacement for the central norbornyl scaffold presented in the recently disclosed novel FLAP inhibitors is herein described, as well as the SAR study performed on the endo and exo-aryl groups.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39018473b521181150efe29b747a22e4
https://doi.org/10.1016/j.bmcl.2012.04.064
https://doi.org/10.1016/j.bmcl.2012.04.064
Autor:
Fabian Chen, Renata Zieba, Brian K. Hubbard, Emanuel Zycband, Oscar Puig, Samuel D. Wright, Xuanmin He, Edward A. O'Neill, Andrew S. Plump, Xiang Yu, Mary M. DeSouza, Sergey B. Stepaniants, Pek Yee Lum, Douglas G. Johns, Dena R. Ramey, Vladimir Reiser, John G. Menke, John Woods, Mark Morris, Silvija Coulter, Eric Hailman, Jeffrey Yuan
Publikováno v:
Circulation: Cardiovascular Genetics. 4:595-604
Background— Atherosclerosis is a complex disease requiring improvements in diagnostic techniques and therapeutic treatments. Both improvements will be facilitated by greater exploration of the biology of atherosclerotic plaque. To this end, we carr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b85f201d48bda108c3129aa726138e
https://doi.org/10.1161/circgenetics.111.960773
https://doi.org/10.1161/circgenetics.111.960773
Publikováno v:
Neurogastroenterology & Motility. 20:1103-1109
Therapy trials with bacterial compounds in irritable bowel syndrome (IBS) have produced conflicting results. This study was performed in 1988 and 1989, and was re-analysed according to current IBS standards. Two hundred ninety-seven patients with low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650c4193a7b7d74746803ac0c49165d5
https://doi.org/10.1111/j.1365-2982.2008.01156.x
https://doi.org/10.1111/j.1365-2982.2008.01156.x
Publikováno v:
DMW - Deutsche Medizinische Wochenschrift. 110:1568-1572
Serum levels of glyceryl trinitrate have been determined in eight healthy subjects following transdermal application of four different glyceryl trinitrate plasters using a randomised crossover design. The plasters investigated were Deponit 10, Nitrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09c8a24a8ba9981b0e0c2415475048c6
https://doi.org/10.1055/s-2008-1069048
https://doi.org/10.1055/s-2008-1069048
Publikováno v:
DMW - Deutsche Medizinische Wochenschrift. 112:719-722
In a randomized crossover study on twelve healthy test subjects, the plasma concentration of isosorbide-5-nitrate (IS-5-N) after oral administration of 40 mg IS-5-N daily from two standard preparations (two tablets Ismo 20 or Corangin 20) and two sus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ac21e5e78acd357b390810173098fb2
https://doi.org/10.1055/s-2008-1068127
https://doi.org/10.1055/s-2008-1068127
Publikováno v:
DMW - Deutsche Medizinische Wochenschrift. 110:1821-1825
The relative bioavailability of isosorbide dinitrate (ISDN) and its mononitrate metabolites (IS-2-MN, IS-5-MN) was determined under repetitive dose conditions in 8 healthy volunteers using a randomised, crossover design. Reference drugs were non-sust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4b45827022dec98b9b10180afdc4e25
https://doi.org/10.1055/s-2008-1069095
https://doi.org/10.1055/s-2008-1069095
Autor:
Denise P. Milot, Jacqueline C. Lopez, Laurence B. Peterson, Alan D. Adams, Samuel D. Wright, Jayne Chin, Lyndon J. Mitnaul, Sandra E. Rex-Rabe, Erik G. Lund, Carl P. Sparrow, John G. Menke, Jenny Tian, My-Hanh Lam, Melanie Latham, Ray Rosa, Shaei Huang, Qiu Guo, Charlotte Burton
Publikováno v:
Biochemical Pharmacology. 71:453-463
Liver X receptor (LXR) alpha and LXRbeta are closely related nuclear receptors that respond to elevated levels of intracellular cholesterol by enhancing transcription of genes that control cholesterol efflux and fatty acid biosynthesis. The consequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ea0719e0902d22d5d332b6d298be3d
https://doi.org/10.1016/j.bcp.2005.11.004
https://doi.org/10.1016/j.bcp.2005.11.004
Autor:
Neelam Sharma, Weiguo Liu, Nancy S. Hayes, Steve Chen, Melba Hernandez, John G. Menke, Carl P. Sparrow, Michael Robins, James F. Dropinski, Michael J. Szymonifka, Lawrence F. Colwell, Sheo B. Singh, Charlotte Burton, Karen L. MacNaul
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4574-4578
A series of podocarpic acid amides were identified as potent agonists for Liver X receptor alpha and beta subtypes, which are members of a nuclear hormone receptor superfamily that are involved in the regulation of a variety of metabolic pathways inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98d886c2edbeb4cb3dc478b4f411a44
https://doi.org/10.1016/j.bmcl.2005.06.100
https://doi.org/10.1016/j.bmcl.2005.06.100
Autor:
Hiranthi Jayasuriya, Anne W. Dombrowski, Ziqiang Guan, John G. Ondeyka, Marvin D. Schulman, Sheo B. Singh, John G. Menke, Christine McCallum, Kithsiri Herath, Soojin S Kwon, Karen L. MacNaul, Javier Collado, Nancy S. Hayes, Neelam Sharma
Publikováno v:
The Journal of Antibiotics. 58:559-565
Cholesterol homeostasis is tightly controlled process that involves a variety of regulators including liver X receptors (LXR). Agonists of LXR are expected to increase cholesterol efflux, lower LDL, and raise HDL levels. Screening of a natural produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493a7fb7e07656b92b6387e04c54f8c8
https://doi.org/10.1038/ja.2005.76
https://doi.org/10.1038/ja.2005.76