Characterisation of tetraspanins from Schistosoma haematobium and evaluation of their potential as novel diagnostic markers.

Autor: Gebeyaw G Mekonnen, Bemnet A Tedla, Mark S Pearson, Luke Becker, Matt Field, Abena S Amoah, Govert van Dam, Paul L A M Corstjens, Takafira Mduluza, Francisca Mutapi, Alex Loukas, Javier Sotillo

Publikováno v: PLoS Neglected Tropical Diseases, Vol 16, Iss 1, p e0010151 (2022)

Schistosoma haematobium is the leading cause of urogenital schistosomiasis and it is recognised as a class 1 carcinogen due to the robust association of infection with bladder cancer. In schistosomes, tetraspanins (TSPs) are abundantly present in dif

Externí odkaz: https://doaj.org/article/83102718f43f43a0bc90839bc6fc9b30

In-depth proteomic characterization of Schistosoma haematobium: Towards the development of new tools for elimination.

Autor: Javier Sotillo, Mark S Pearson, Luke Becker, Gebeyaw G Mekonnen, Abena S Amoah, Govert van Dam, Paul L A M Corstjens, Janice Murray, Takafira Mduluza, Francisca Mutapi, Alex Loukas

Publikováno v: PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007362 (2019)

BackgroundSchistosomiasis is a neglected disease affecting hundreds of millions worldwide. Of the three main species affecting humans, Schistosoma haematobium is the most common, and is the leading cause of urogenital schistosomiasis. S. haematobium

Externí odkaz: https://doaj.org/article/a19f474dc61e4ecb819f8f24a7aa8891

Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study

Autor: Cornelis H. Hokke, Donald P. McManus, Alex Loukas, Govert J. van Dam, Takafira Mduluza, Said M. Ali, Thewarach Laha, Al Jasinskas, Maria Elena Bottazzi, Mark S. Pearson, Beatrice Greco, Sujittra Chaiyadet, A.A. Adegnika, Paul L. A. M. Corstjens, Matthew A. Field, Abena S. Amoah, Denise L. Doolan, Gebeyaw G Mekonnen, Javier Sotillo, Fatma Kabole, Claude Oeuvray, Bemnet Amare Tedla, Carla Proietti, Philip L. Felgner, Stefanie Knopp, Rie Nakajima, Luke Becker, David Rollinson, Pengfei Cai, Francisca Mutapi

Publikováno v: The Lancet. Microbe
The Lancet Microbe, 2(11), E617-E626. ELSEVIER
Repisalud
Instituto de Salud Carlos III (ISCIII)
Pearson, M S, Tedla, B A, Mekonnen, G G, Proietti, C, Becker, L, Nakajima, R, Jasinskas, A, Doolan, D L, Amoah, A S, Knopp, S, Rollinson, D, Ali, S M, Kabole, F, Hokke, C H, Adegnika, A A, Field, M A, van Dam, G, Corstjens, P L A M, Mduluza, T, Mutapi, F, Oeuvray, C, Greco, B, Chaiyadet, S, Laha, T, Cai, P, McManus, D P, Bottazzi, M E, Felgner, P L, Sotillo, J & Loukas, A 2021, ' Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis : A biomarker identification study ', The Lancet Microbe, vol. 2, no. 11, pp. e617-e626 . https://doi.org/10.1016/S2666-5247(21)00150-6
The Lancet Microbe, Vol 2, Iss 11, Pp e617-e626 (2021)

Background: Sensitive diagnostics are needed for effective management and surveillance of schistosomiasis so that current transmission interruption goals set by WHO can be achieved. We aimed to screen the Schistosoma haematobium secretome to find ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3119662e8eb6345c63b19a01892565c9
http://europepmc.org/articles/PMC8683377

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