Zobrazeno 1 - 10
of 480
pro vyhledávání: '"G. Masucci"'
Autor:
Jiangnan Liu, Noemi Nagy, Carlos Ayala-Torres, Francisco Aguilar-Alonso, Francisco Morais-Esteves, Shanshan Xu, Maria G. Masucci
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The strategies adopted by viruses to reprogram the translation and protein quality control machinery and promote infection are poorly understood. Here, we report that the viral ubiquitin deconjugase (vDUB)—encoded in the large tegument pro
Externí odkaz:
https://doaj.org/article/4cf2909b00384b029e5c0b1e22fa8b58
Autor:
Maria Camila Quinones, Karl Bélanger, Émilie Lemieux Blanchard, Bernard Lemieux, Jean-Paul Bahary, Laura G. Masucci, David Roberge, Cynthia Menard, Carole Lambert, France Berthelet, Robert Moumdjian, Marie Florescu
Publikováno v:
Current Oncology, Vol 28, Iss 4, Pp 3104-3114 (2021)
Medulloblastoma is an aggressive primary brain tumor that is extremely rare in adults; therefore, prospective studies are limited. We reviewed the information of all MB patients treated at the CHUM between 2006 and 2017. We divided our cohort by age
Externí odkaz:
https://doaj.org/article/c2ccf3c1d3264f7f9b2f50048166e180
Autor:
Jinlin Li, Noemi Nagy, Jiangnan Liu, Soham Gupta, Teresa Frisan, Thomas Hennig, Donald P Cameron, Laura Baranello, Maria G Masucci
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009954 (2021)
Topoisomerases are essential for the replication of herpesviruses but the mechanisms by which the viruses hijack the cellular enzymes are largely unknown. We found that topoisomerase-II (TOP2) is a substrate of the Epstein-Barr virus (EBV) ubiquitin
Externí odkaz:
https://doaj.org/article/19987ba58b534c27bc4d47f405f3f9d1
Autor:
Maria G. Masucci
Publikováno v:
Seminars in Cell & Developmental Biology. 132:185-192
The covalent attachment of ubiquitin and ubiquitin-like polypeptides to cellular and viral proteins regulates numerous processes that enable virus infection, viral genome replication, and the spread of viruses to new hosts. The importance of these pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68dc397b6cb05717db19e6837a5dc1ab
https://doi.org/10.1016/j.semcdb.2021.10.011
https://doi.org/10.1016/j.semcdb.2021.10.011
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The hijacking of cellular function through expression of proteins that interfere with the activity of cellular enzymes and regulatory complexes is a common strategy used by viruses to remodel the cell environment in favor of their own replication and
Externí odkaz:
https://doaj.org/article/23de2fbbd5f5426ca73f8fb8abe69035
Publikováno v:
Microbial Cell, Vol 5, Iss 5, Pp 259-261 (2018)
Upon infection, viral nucleic acids are recognized by germline-encoded pattern-recognition receptors (PRRs), and cytosolic retinoic acid-inducible gene I (RIG-I)-like helicases (RLHs) that initiate signaling pathways resulting in the production of ty
Externí odkaz:
https://doaj.org/article/fc320c6dca1c4b2fa5ede97548092ff8
Autor:
Soham Gupta, Päivi Ylä-Anttila, Tatyana Sandalova, Renhua Sun, Adnane Achour, Maria G Masucci
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008146 (2019)
The 14-3-3 molecular scaffolds promote type I interferon (IFN) responses by stabilizing the interaction of RIG-I with the TRIM25 ligase. Viruses have evolved unique strategies to halt this cellular response to support their replication and spread. He
Externí odkaz:
https://doaj.org/article/85ced8dfa3074c97863a92fe748c0c4e
Remodeling of the Ribosomal Quality Control and Protein Translation by a Viral Ubiquitin Deconjugase
Autor:
Jiangnan Liu, Noemi Nagy, Francisco Aguilar-Alonso, Francisco Esteves, Carlos Ayala-Torres, Shanshan Xu, Maria G. Masucci
SUMMARYThe strategies adopted by viruses to reprogram the protein translation and quality control machineries to promote infection are poorly understood. Here, we discovered that the viral ubiquitin deconjugase (vDUB) encoded in the large tegument pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b94a673814fcb101929c20047e6d2e97
https://doi.org/10.1101/2023.01.31.526464
https://doi.org/10.1101/2023.01.31.526464
Autor:
Soham Gupta, Päivi Ylä-Anttila, Simone Callegari, Ming-Han Tsai, Henri-Jacques Delecluse, Maria G Masucci
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006852 (2018)
The N-terminal domains of the herpesvirus large tegument proteins encode a conserved cysteine protease with ubiquitin- and NEDD8-specific deconjugase activity. The proteins are expressed during the productive virus cycle and are incorporated into inf
Externí odkaz:
https://doaj.org/article/44068917e38649e192a65f6e7a6fdcf8
Autor:
Maria G. Masucci, Päivi Ylä-Anttila
Publikováno v:
Biochemical Journal
Autophagy is an important component of the innate immune response that restricts infection by different types of pathogens. Viruses have developed multiple strategies to avoid autophagy to complete their replication cycle and promote spreading to new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca141d8cb9431bb2156da1dd24cce963
https://doi.org/10.1042/bcj20210225
https://doi.org/10.1042/bcj20210225