Negative Cooperativity in the Mechanism of Prenylated-Flavin-Dependent Ferulic Acid Decarboxylase: A Proposal for a 'Two-Stroke' Decarboxylation Cycle

Autor: April K. Kaneshiro, Prathamesh M. Datar, E. Neil G. Marsh

Publikováno v: Biochemistry. 62:53-61

Ferulic acid decarboxylase (FDC) catalyzes the reversible carboxylation of various substituted phenylacrylic acids to produce the correspondingly substituted styrenes and CO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16e2002f19d8e622bdcd902704ebec3
https://doi.org/10.1021/acs.biochem.2c00460

Searches for new physics below twice the electron mass with GERDA

Autor: GERDA Collaboration, M. Agostini, A. Alexander, G. Araujo, A. M. Bakalyarov, M. Balata, I. Barabanov, L. Baudis, C. Bauer, S. Belogurov, A. Bettini, L. Bezrukov, V. Biancacci, E. Bossio, V. Bothe, R. Brugnera, A. Caldwell, S. Calgaro, C. Cattadori, A. Chernogorov, P.-J. Chiu, T. Comellato, V. D’Andrea, E. V. Demidova, N. Di Marco, E. Doroshkevich, M. Fomina, A. Gangapshev, A. Garfagnini, C. Gooch, P. Grabmayr, V. Gurentsov, K. Gusev, J. Hakenmüller, S. Hemmer, W. Hofmann, J. Huang, M. Hult, L. V. Inzhechik, J. Janicskó Csáthy, J. Jochum, M. Junker, V. Kazalov, Y. Kermaïdic, H. Khushbakht, T. Kihm, K. Kilgus, I. V. Kirpichnikov, A. Klimenko, K. T. Knöpfle, O. Kochetov, V. N. Kornoukhov, P. Krause, V. V. Kuzminov, M. Laubenstein, M. Lindner, I. Lippi, A. Lubashevskiy, B. Lubsandorzhiev, G. Lutter, C. Macolino, B. Majorovits, W. Maneschg, G. Marshall, M. Misiaszek, M. Morella, Y. Müller, I. Nemchenok, M. Neuberger, L. Pandola, K. Pelczar, L. Pertoldi, P. Piseri, A. Pullia, C. Ransom, L. Rauscher, M. Redchuk, S. Riboldi, N. Rumyantseva, C. Sada, S. Sailer, F. Salamida, S. Schönert, J. Schreiner, A-K. Schütz, O. Schulz, M. Schwarz, B. Schwingenheuer, O. Selivanenko, E. Shevchik, M. Shirchenko, L. Shtembari, H. Simgen, A. Smolnikov, D. Stukov, S. Sullivan, A. A. Vasenko, A. Veresnikova, C. Vignoli, K. von Sturm, T. Wester, C. Wiesinger, M. Wojcik, E. Yanovich, B. Zatschler, I. Zhitnikov, S. V. Zhukov, D. Zinatulina, A. Zschocke, K. Zuber, G. Zuzel

Publikováno v: European Physical Journal C: Particles and Fields, Vol 84, Iss 9, Pp 1-19 (2024)

Abstract A search for full energy depositions from bosonic keV-scale dark matter candidates of masses between 65 and 1021 keV has been performed with data collected during Phase II of the GERmanium Detector Array (Gerda) experiment. Our analysis incl

Externí odkaz: https://doaj.org/article/0c38fc56ad6b4043a5f525f889a2d16b

Machine learning classifier approaches for predicting response to RTK-type-III inhibitors demonstrate high accuracy using transcriptomic signatures and ex vivo data

Autor: Mauricio H Ferrato, Adam G Marsh, Karl R Franke, Benjamin J Huang, E Anders Kolb, Deborah DeRyckere, Douglas K Grahm, Sunita Chandrasekaran, Erin L Crowgey

Publikováno v: Bioinformatics Advances. 3

Motivation The application of machine learning (ML) techniques in the medical field has demonstrated both successes and challenges in the precision medicine era. The ability to accurately classify a subject as a potential responder versus a nonrespon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62f77438569de74853c9e46d43ea2a5d
https://doi.org/10.1093/bioadv/vbad034

Decarboxylation of Aromatic Carboxylic Acids by the Prenylated-FMN-dependent Enzyme Phenazine-1-carboxylic Acid Decarboxylase

Autor: E. Neil G. Marsh, Prathamesh M. Datar

Publikováno v: ACS Catalysis. 11:11723-11732

Phenazine-1-carboxylic acid decarboxylase (PhdA) is a member of the expanding class of prenylated-FMN-dependent (prFMN) decarboxylase enzymes. These enzymes have attracted interest for their abilit...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::610324821256ff6b75490136318c68e7
https://doi.org/10.1021/acscatal.1c03040

Purification of the full-length, membrane-associated form of the antiviral enzyme viperin utilizing nanodiscs

Autor: Ayesha M. Patel, Karl J. Koebke, Timothy J. Grunkemeyer, Colleen M. Riordan, Youngsoo Kim, Ryan C. Bailey, E. Neil G. Marsh

Publikováno v: Scientific Reports. 12

Viperin is a radical S-adenosylmethionine enzyme that catalyzes the formation of the antiviral ribonucleotide, 3’-deoxy-3’,4’-didehydroCTP. The enzyme is conserved across all kingdoms of life, and in higher animals viperin is localized to the E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2b1617e224fac822a29e9ce6d530e2
https://doi.org/10.1038/s41598-022-16233-z