Výsledky vyhledávání - "G. Mark Latham"

Scalable Synthesis of a Nucleoside Phosphoramidate Prodrug Inhibitor of HCV NS5B RdRp: Challenges in the Production of a Diastereomeric Mixture

Autor: Roberta Glynn, Steven Mathieu, David Bauer, Jeevanandam Arumugasamy, Jie Li, Jingyang Wang, Alistair Stewart, Alan Becker, Jinsoo Lim, Elodie Rosinovsky, F. Patrick McGarry, Narayan Chaudhuri, G. Mark Latham, Erkan Baloglu, Adrien F. Soret, Kannan Arunachalam, Jia Liu, Adel Moussa, Benjamin Alexander Mayes

Publikováno v: Organic Process Research & Development. 19:520-530

A scalable process is described for the synthesis of 2′-C-methylguanosine-5′-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate], a nucleotide prodrug inhibitor of hepatitis C virus NS5B polymerase. The route features the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59db1becbb4e9c2c9f190d64e71e6d6b
https://doi.org/10.1021/op5003837

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Synthesis of a Nucleoside Phosphoramidate Prodrug Inhibitor of HCV NS5B Polymerase: Phenylboronate as a Transient Protecting Group

Autor: Elodie Rosinovsky, Narayan Chaudhuri, Benjamin Alexander Mayes, Christophe Trochet, Steven Mathieu, G. Mark Latham, Alistair Stewart, Adel Moussa, Jie Li, Jeevanandam Arumugasamy, Alan Becker, Erkan Baloglu, F. Patrick McGarry, Jingyang Wang, David Bauer

Publikováno v: Organic Process Research & Development. 18:717-724

A synthetic process for 2′-C-methylcytidine-5′-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate], a nucleotide prodrug inhibitor of hepatitis C virus NS5B polymerase, is described. The route developed was demonstrated on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6560b20a8c693f5283f4af20fa03985c
https://doi.org/10.1021/op500042u

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Development of Related HCV Protease Inhibitors: Macrocyclization of Two Highly Functionalized Dienyl-ureas via Ring-Closing Metathesis

Autor: Xinghua Wu, Jia Liu, Catherine Caillet, Aurelien E. Salanson, Kannan Arunachalam, David Bauer, Jeevanandam Arumugasamy, Elodie Rosinovsky, Jingyang Wang, G. Mark Latham, Benjamin Alexander Mayes, Roberta Glynn, Alistair Stewart, Jinsoo Lim, Alan Becker, Adrien F. Soret, Adel Moussa

Publikováno v: Organic Process Research & Development. 17:811-828

A novel assembly of two structurally related 14-membered ring macrocyclic hepatitis C virus protease inhibitors is presented. Key to their successful construction was an ultimate ring-closing metathesis step on the respective highly functionalized di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::031e1232dac381e175cc5e16fece6b3b
https://doi.org/10.1021/op300296t

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Robust Synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate: A Key Intermediate in the Preparation of an HIV NNRTI Candidate

Autor: Steven Mathieu, Adel Moussa, Jingyang Wang, Narayan Chaudhuri, Alistair Stewart, Frederic Jeannot, G. Mark Latham, Christopher P. Hencken, F. Patrick McGarry, Benjamin Alexander Mayes

Publikováno v: Organic Process Research & Development. 14:1248-1253

A synthetic preparation of methyl 5-chloro-4-fluoro-1H-indole-2-carboxylate, a key intermediate towards phosphoindole inhibitors of HIV non-nucleoside reverse transcriptase, is described. The five-step synthesis involved Boc protection of the commerc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::652b1f65a8b5d87a054125368a49fe7c
https://doi.org/10.1021/op1001808

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The preparation of N-(1H-pyrazol-3-yl)arylamides and 1H-pyrazol-3-amines from polylithiated C(α),N-thiosemicarbazones and C(α),N-semicarbazones

Autor: Camille M. Kassis, Sharon E. Davis, Karen C. Hildebran, Charles F. Beam, Tracy L. Cordray, Clyde R. Metz, Madlene U. Koller, Kam W. Chan, William T. Pennington, A. Cameron Church, Kevin L. Schey, Tina S. Guion, G. Mark Latham, Joanna G. Freeman Davis

Publikováno v: Journal of Heterocyclic Chemistry. 34:1549-1554

C(α),N-Thiosemicarbazones or C(α),N-semicarbazones were polylithiated with excess lithium diiso-propylamide, and the resulting cyclized intermediates were condensed with aromatic esters to afford N-(1H-pyrazol-3-yl)arylamides. The polylithiated int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79c647565758ff1b9966f22e454cc38f
https://doi.org/10.1002/jhet.5570340527

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Akademický článek

ScalableSynthesis of a Nucleoside PhosphoramidateProdrug Inhibitor of HCV NS5B RdRp: Challenges in the Production ofa Diastereomeric Mixture.

Autor: Benjamin A. Mayes, Jingyang Wang, Jeevanandam Arumugasamy, Kannan Arunachalam, Erkan Baloglu, David Bauer, Alan Becker, Narayan Chaudhuri, Roberta Glynn, G. Mark Latham, Jie Li, Jinsoo Lim, Jia Liu, Steve Mathieu, F. Patrick McGarry, Elodie Rosinovsky, Adrien F. Soret, Alistair Stewart, Adel Moussa

Publikováno v: Organic Process Research & Development; Apr2015, Vol. 19 Issue 4, p520-530, 11p

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Akademický článek

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