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The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis

Autor: G. Marden, Q. Wan, J. Wilks, K. Nevin, M. Feeney, N. Wisniacki, M. Trojanowski, A. Bujor, L. Stawski, M. Trojanowska

Publikováno v: Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-14 (2020)

Abstract Background Scleroderma (SSc) is a rare autoimmune disease characterized by vascular impairment and progressive fibrosis of the skin and other organs. Oncostatin M, a member of the IL-6 family, is elevated in SSc serum and was recognized as a

Externí odkaz: https://doaj.org/article/7ef7979e19664c3fa895787635bfd1a4

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Dysfunctional ERG Signaling Drives Pulmonary Vascular Aging and Progressive Fibrosis

Autor: N. Caporarello, T.X. Pham, J. Lee, J. Guan, J.A. Meridew, D.L. Jones, G. Marden, T. Yamashita, R.F. Nicosia, M. Trojanowska, G. Ligresti

Publikováno v: C9. C009 MODULATORS OF LUNG INJURY AND REPAIR.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59f025e705394af78c16892be1835994
https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1142

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Additional file 5 of The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis

Autor: G. Marden, Q. Wan, J. Wilks, K. Nevin, M. Feeney, N. Wisniacki, M. Trojanowski, A. Bujor, L. Stawski, Trojanowska, M.

Additional file 5: Supplemental Table I. Human primers used for real-time PCR.

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Additional file 2 of The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis

Autor: G. Marden, Q. Wan, J. Wilks, K. Nevin, M. Feeney, N. Wisniacki, M. Trojanowski, A. Bujor, L. Stawski, Trojanowska, M.

Additional file 2: Supplementary Figure 2. Effect of OSM on the mRNA levels of profibrotic genes in HDMECs. mRNA levels of profibrotic genes were analyzed by quantitative qPCR, n = 3. Students t-test *p

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Additional file 6 of The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis

Autor: G. Marden, Q. Wan, J. Wilks, K. Nevin, M. Feeney, N. Wisniacki, M. Trojanowski, A. Bujor, L. Stawski, Trojanowska, M.

Additional file 6: Supplemental Table II. Antibodies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfbf8ee985d06a2b18f65d49dca8a9c

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Additional file 4 of The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis

Autor: G. Marden, Q. Wan, J. Wilks, K. Nevin, M. Feeney, N. Wisniacki, M. Trojanowski, A. Bujor, L. Stawski, Trojanowska, M.

Additional file 4: Supplementary Figure 4. Double IHC staining of PDGFRβ/pSTAT3 and PDGFRβ/PDPN in OSM treated skin cultures. Double IHC staining of PDGFRβ/pSTAT3 (A) and PDGFRβ/PDPN (B) was performed on paraffin sections from the OSM and IL-6+IL

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Additional file 3 of The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis

Autor: G. Marden, Q. Wan, J. Wilks, K. Nevin, M. Feeney, N. Wisniacki, M. Trojanowski, A. Bujor, L. Stawski, Trojanowska, M.

Additional file 3: Supplementary Figure 3. Effect of OSM and IL-6+sIL-6R on migration and proliferation of HDMECs. Migration (A) and proliferation (B) were examined with the Essen BioScience IncuCyte Live-Cell Imaging system. Data represent n = 3 wel

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Additional file 1 of The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis

Autor: G. Marden, Q. Wan, J. Wilks, K. Nevin, M. Feeney, N. Wisniacki, M. Trojanowski, A. Bujor, L. Stawski, Trojanowska, M.

Additional file 1: Supplementary Figure 1. Distribution of OSM in human skin biopsies from healthy controls and SSc patients. A. IHC staining of OSM was performed on paraffin sections from the skin of three SSc patients and three healthy controls 50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526c096829a5cb6690547467b9945636

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