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Crystallographic Studies with Xenon and Nitrous Oxide Provide Evidence for Protein-dependent Processes in the Mechanisms of General Anesthesia

Autor: Hélène N. David, Nathalie Colloc'h, G. Marassio, Thierry Prangé, Jacques H. Abraini, Beatrice Vallone

Publikováno v: Anesthesiology
Anesthesiology, Lippincott, Williams & Wilkins, 2014, 121 (5), pp.1018-1027. 〈10.1097/ALN.0000000000000435〉
Anesthesiology, 2014, 121 (5), pp.1018-1027. ⟨10.1097/ALN.0000000000000435⟩
Anesthesiology, Lippincott, Williams & Wilkins, 2014, 121 (5), pp.1018-1027. ⟨10.1097/ALN.0000000000000435⟩

Background: The mechanisms by which general anesthetics, including xenon and nitrous oxide, act are only beginning to be discovered. However, structural approaches revealed weak but specific protein–gas interactions. Methods: To improve knowledge,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122d715cb2c55619f1ae547e2e6b05da
https://hal.archives-ouvertes.fr/hal-01626697

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Protein-Noble Gas Interactions Investigated by Crystallography on Three Enzymes - Implication on Anesthesia and Neuroprotection Mechanisms

Autor: G. Marassio, Nathalie Colloc'h, Thierry Prangé

Publikováno v: Current Trends in X-Ray Crystallography

General anesthetics have been used in clinical practice since the middle of the XIXth century, but their molecular mechanisms of action on the nervous system remains poorly understood. The main targets of most inhalational anesthetic are pentameric l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8db5676a26a5bc1cb9af780f8da1f9
http://www.intechopen.com/articles/show/title/protein-noble-gas-interactions-investigated-by-crystallography-on-three-enzymes-implication-on-anest

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A Pressure-response analysis of anesthetic gases xenon and nitrous oxide on urate oxidase: a crystallographic study

Autor: Jana Sopkova-de Oliveira Santos, Jacques H. Abraini, G. Marassio, Nathalie Colloc'h, Hélène N. David, Thierry Prangé, Nicolas Delcroix, L. Gabison

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2011, 25, pp.1-10. ⟨10.1096/fj.11-183046⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2011, 25, pp.1-10. 〈10.1096/fj.11-183046〉
FASEB Journal, 2011, 25, pp.1-10. ⟨10.1096/fj.11-183046⟩

The remarkably safe anesthetics xenon (Xe) and, to lesser extent, nitrous oxide (N(2)O) possess neuroprotective properties in preclinical studies. To investigate the mechanisms of pharmacological action of these gases, which are still poorly known, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d6a9f05c5e27f1b15c8fa886ed32e3
https://hal.archives-ouvertes.fr/hal-01061836

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Oxygen pressurized X-ray crystallography: probing the dioxygen binding site in cofactorless urate oxidase and implications for its catalytic mechanism

Autor: M. Chiadmi, Bertrand Castro, Mohamed El Hajji, Jana Sopkova-de Oliveira Santos, Jacques H. Abraini, G. Marassio, Nathalie Colloc'h, Gérald Monard, Muhannad Altarsha, Thierry Prangé, L. Gabison

Publikováno v: Biophysical journal. 95(5)

The localization of dioxygen sites in oxygen-binding proteins is a nontrivial experimental task and is often suggested through indirect methods such as using xenon or halide anions as oxygen probes. In this study, a straightforward method based on x-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022c2ae3a03b0e5db5e143973200564a
https://pubmed.ncbi.nlm.nih.gov/18375516

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Mechanism of the cofactor-less urate oxidase: X-ray structures with molecular oxygen or cyanide

Autor: N. Colloc'h, G. Marassio, L. Gabison, M. Chiadmi, Thierry Prangé

Publikováno v: Acta Crystallographica Section A Foundations of Crystallography. 64:C122-C122

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24d8129b9caefd27d9a556b94115817d
https://doi.org/10.1107/s0108767308096062

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