Zobrazeno 1 - 10
of 54
pro vyhledávání: '"G. M. van Woerden"'
Autor:
M. R. F. Reijnders, M. Kousi, G. M. van Woerden, M. Klein, J. Bralten, G. M. S. Mancini, T. van Essen, M. Proietti-Onori, E. E. J. Smeets, M. van Gastel, A. P. A. Stegmann, S. J. C. Stevens, S. H. Lelieveld, C. Gilissen, R. Pfundt, P. L. Tan, T. Kleefstra, B. Franke, Y. Elgersma, N. Katsanis, H. G. Brunner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The mTOR pathway is a key regulator of normal brain development. Here, the authors identify de novo mutations in RHEB, an mTOR activator protein, in patients with intellectual disability associated with megalencephaly and find a role for RHEB in regu
Externí odkaz:
https://doaj.org/article/ea6460e697d849ef87cfd70a3e73e744
Autor:
Ulrike Leurs, R. O. Burnie, S. M. Solbak, Anders B. Klein, Chris C. Chi, Bente Frølund, Anders Bach, Nane Griem-Krey, Christine L. Gee, Inge S. Villumsen, Rasmus P. Clausen, Birgitte Rahbek Kornum, D. S. Kerr, Emma K. Gowing, Jesper V. Olsen, A. S. G. Larsen, John Kuriyan, Stine B. Vogensen, L. B. Palmelund, Louise Hamborg, S. M. W. Teurlings, Petrine Wellendorph, S. J. Gauger, Ethan D McSpadden, Andrew N. Clarkson, G. M. van Woerden, Mohamed A. Shehata, Christian D. Kelstrup, Josh Houlton
Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) is an abundant neuronal signaling protein involved in synaptic plasticity and memory formation1,2. The central hub domain regulates the activity of CaMKIIα by organizing the holoenzyme com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cce8ff6378c9b62a7d65b4c63a3e8f74
https://doi.org/10.1101/2020.09.28.310474
https://doi.org/10.1101/2020.09.28.310474
Publikováno v:
Advanced healthcare materials
5 (2016): 850–862. doi:10.1002/adhm.201500815
info:cnr-pdr/source/autori:Tonazzini I.; Meucci S.; Van Woerden G. M.; Elgersma Y.; Cecchini M./titolo:Impaired Neurite Contact Guidance in Ubiquitin Ligase E3a (Ube3a)-Deficient Hippocampal Neurons on Nanostructured Substrates/doi:10.1002%2Fadhm.201500815/rivista:Advanced healthcare materials (Print)/anno:2016/pagina_da:850/pagina_a:862/intervallo_pagine:850–862/volume:5
Advanced healthcare materials, 5(7), 850-862. John Wiley & Sons Ltd.
5 (2016): 850–862. doi:10.1002/adhm.201500815
info:cnr-pdr/source/autori:Tonazzini I.; Meucci S.; Van Woerden G. M.; Elgersma Y.; Cecchini M./titolo:Impaired Neurite Contact Guidance in Ubiquitin Ligase E3a (Ube3a)-Deficient Hippocampal Neurons on Nanostructured Substrates/doi:10.1002%2Fadhm.201500815/rivista:Advanced healthcare materials (Print)/anno:2016/pagina_da:850/pagina_a:862/intervallo_pagine:850–862/volume:5
Advanced healthcare materials, 5(7), 850-862. John Wiley & Sons Ltd.
Recent discoveries indicate that during neuronal development the signaling processes that regulate extracellular sensing (e.g., adhesion, cytoskeletal dynamics) are important targets for ubiquitination-dependent regulation, in particular through E3 u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892b341456ad224598e2294cef3ec5f9
https://doi.org/10.1002/adhm.201500815
https://doi.org/10.1002/adhm.201500815
Publikováno v:
Genes Brain and Behavior, 10(4), 404-409. Wiley-Blackwell Publishing Ltd
Genes Brain and Behavior, 10, 404-409. Wiley-Blackwell
Genes Brain and Behavior, 10, 404-409. Wiley-Blackwell
Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited disease, characterized by various neurocutaneous symptoms, cognitive impairments and problems in fine and gross motor performance. Although cognitive deficits in NF1 have been attrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42116c2fb155f239044f3be4dba4bbc
https://doi.org/10.1111/j.1601-183x.2011.00685.x
https://doi.org/10.1111/j.1601-183x.2011.00685.x
Publikováno v:
European Journal of Neuroscience, 27(10), 2542-2550. Wiley-Blackwell Publishing Ltd
European Journal of Neuroscience, 27(10), 2542-2550. Wiley-Blackwell
European Journal of Neuroscience, 27(10), 2542-2550. Wiley-Blackwell
Corticosterone (100 nm) rapidly increases the frequency of miniature excitatory postsynaptic currents in mouse CA1 pyramidal neurons via membrane-located mineralocorticoid receptors (MRs). We now show that a presynaptic ERK1/2 signalling pathway medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4282f726d7a4ee0e68ca10baf4aba5f
https://doi.org/10.1111/j.1460-9568.2008.06220.x
https://doi.org/10.1111/j.1460-9568.2008.06220.x
Autor:
Azar Omrani, Christiaan N. Levelt, Ka Wan Li, August B. Smit, Alcino J. Silva, Mohammad Reza Hojjati, Ype Elgersma, T. van der Vaart, Steven A. Kushner, Edwin Mientjes, David H. Gutmann, G. M. van Woerden
Publikováno v:
Molecular Psychiatry, 20(11), 1311-21. Nature Publishing Group
Omrani, A, Van der Vaart, A, Mientjes, E, Woerden, G M, Hojjati, M R, Li, K W, Gutmann, D H, Levelt, C N, Smit, A B, Silva, A J, Kushner, S A & Elgersma, Y 2015, ' HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1. ', Molecular Psychiatry, vol. 20, no. 11, pp. 1311-1321 . https://doi.org/10.1038/mp.2015.48
Molecular psychiatry, vol 20, iss 11
Molecular Psychiatry, 20(11), 1311-1321. Nature Publishing Group
Omrani, A, Van der Vaart, A, Mientjes, E, Woerden, G M, Hojjati, M R, Li, K W, Gutmann, D H, Levelt, C N, Smit, A B, Silva, A J, Kushner, S A & Elgersma, Y 2015, ' HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1. ', Molecular Psychiatry, vol. 20, no. 11, pp. 1311-1321 . https://doi.org/10.1038/mp.2015.48
Molecular psychiatry, vol 20, iss 11
Molecular Psychiatry, 20(11), 1311-1321. Nature Publishing Group
Cognitive impairments are a major clinical feature of the common neurogenetic disease neurofibromatosis type 1 (NF1). Previous studies have demonstrated that increased neuronal inhibition underlies the learning deficits in NF1, however, the molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d489f27b0bd0b067cd678c2092c17c
https://pure.knaw.nl/portal/en/publications/3ac1bc09-c4db-4533-93fe-f666c29adbbd
https://pure.knaw.nl/portal/en/publications/3ac1bc09-c4db-4533-93fe-f666c29adbbd
Autor:
Momma, Tony Y., Kuhnle, Gunter G. C., Fong, Reedmond Y., Ensunsa, Jodi L., Crozier, Alan, Schroeter, Hagen, Ottaviani, Javier I.
Publikováno v:
Molecular Nutrition & Food Research; Sep2023, Vol. 67 Issue 17, p1-10, 10p
Autor:
Ebstein, Frédéric, Küry, Sébastien, Most, Victoria, Rosenfelt, Cory, Scott-Boyer, Marie-Pier, van Woerden, Geeske M., Besnard, Thomas, Papendorf, Jonas Johannes, Studencka-Turski, Maja, Wang, Tianyun, Hsieh, Tzung-Chien, Golnik, Richard, Baldridge, Dustin, Forster, Cara, de Konink, Charlotte, Teurlings, Selina M.W., Vignard, Virginie, van Jaarsveld, Richard H., Ades, Lesley, Cogné, Benjamin
Publikováno v:
Science Translational Medicine; 5/31/2023, Vol. 15 Issue 698, p1-19, 19p
Autor:
Alfred Xuyang Sun1,2 sunxya@gis.a-star.edu.sg, Qiang Yuan3,4, Masahiro Fukuda4, Weonjin Yu4, Haidun Yan5, Grace Gui Yin Lim1, Mui Hoon Nai6, D’Agostino, Giuseppe Alessandro7, Hoang-Dai Tran2, Yoko Itahana8, Danlei Wang1, Lokman, Hidayat4, Itahana, Koji8, Wai Lin Lim, Stephanie4, Jiong Tang9, Ya Yin Chang1, Menglan Zhang4, Cook, Stuart A.7, Rackham, Owen J. L.7, Chwee Teck Lim6
Publikováno v:
Science. 12/20/2019, Vol. 366 Issue 6472, p1486-1492. 7p. 4 Diagrams.
Autor:
Dindot, Scott V., Christian, Sarah, Murphy, William J., Berent, Allyson, Panagoulias, Jennifer, Schlafer, Annalise, Ballard, Johnathan, Radeva, Kamelia, Robinson, Ruth, Myers, Luke, Jepp, Thomas, Shaheen, Hillary, Hillman, Paul, Konganti, Kranti, Hillhouse, Andrew, Bredemeyer, Kevin R., Black, Lauren, Douville, Julie, Weeber, Edwin, Segal, David
Publikováno v:
Science Translational Medicine; 3/22/2023, Vol. 15 Issue 688, p1-12, 12p