Zobrazeno 1 - 10
of 25
pro vyhledávání: '"G. M. Pieper"'
Syngeneic pancreatic islet transplantation reverses endothelial dysfunction in experimental diabetes
Publikováno v:
Diabetes. 44:1106-1113
Publikováno v:
Diabetes. 44:884-889
Publikováno v:
Surgery. 123(1)
There is insufficient evidence whether transplantation of the whole pancreas can reverse vascular complications associated with diabetes. In this study we investigated whether pancreatic transplantation in experimental diabetes reverses established d
Autor:
G M, Pieper, L A, Dondlinger
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(2)
Arginine is a precursor amino acid for the synthesis of nitric oxide by nitric oxide synthase. A defect in arginine supply could regulate nitric oxide-mediated, endothelium-dependent relaxation. In this study, we evaluated the effect of supplementati
Autor:
G M, Pieper, W, Siebeneich
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(1)
Nitronyl nitroxides react with nitric oxide radical (.NO) to form imino nitroxides. We used a nitronyl nitroxide, [2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl 3 oxide] (CPTIO) to evaluate the contribution of .NO to basal tone and acetyl
Publikováno v:
Cardiovascular drugs and therapy. 11(3)
Oxygen-derived free radicals are believed to be involved in diabetes-induced vascular complications. The role of oxygen radicals in endothelial dysfunction in diabetes is not known with certainty. In this study we tested whether inhibition of lipid p
Publikováno v:
Annals of the New York Academy of Sciences. 723
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 269(2)
Nitrovasodilators, particularly the nitric oxide donor agents, are known to inhibit leukocyte functions such as chemotaxis, adherence, migration and proteolytic enzyme release. In this study, we investigated the modulatory role of nitric oxide donor
Autor:
A M, Roza, D P, Slakey, G M, Pieper, T M, Van Ye, G, Moore-Hilton, R A, Komorowski, C P, Johnson, B E, Hedlund, M B, Adams
Publikováno v:
The Journal of laboratory and clinical medicine. 123(4)
Hydroxyl radicals (.OH) may contribute to beta cell death. Because iron catalyzes .OH production, we examined whether administration of a novel, long-acting iron chelator, hydroxyethyl starch-deferoxamine (HES-DFO) could prevent diabetes in spontaneo
Autor:
D P, O'Hair, A M, Roza, R, Komorowski, G, Moore, R P, McManus, C P, Johnson, M B, Adams, G M, Pieper
Publikováno v:
Journal of lipid mediators. 7(1)
Hyperacute rejection is a serious complication of xenogeneic organ transplantation. It is believed that platelets play a pivotal role in this phenomenon. In this study, we provide the first known evidence of the efficacy of the PAF receptor antagonis