GTP synthases. Proton pumping and phosphorylation in ligand-receptor-G alpha-protein complexes

Autor: P H, Nederkoorn, H, Timmerman, G M, Donné-Op Den Kelder, D, Timms, A J, Wilkinson, D R, Kelly, K J, Broadley, R H, Davies

Publikováno v: Receptorschannels. 4(2)

A structural model for a ligand-receptor-Gs alpha-protein complex to function as a GTP synthase is presented. The mechanism which is dependent on the movement and rotation of the G alpha-protein alpha 2-helix is seen to involve the delivery of, at le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1bfadadae2835c0438c525444008ed93
https://pubmed.ncbi.nlm.nih.gov/8865363

A theoretical study concerning the mode of interaction of the histamine H2-agonist dimaprit

Autor: Hendrik Timmerman, E. E. J. Haaksma, G. M. Donné-Op den Kelder, P. Vernooijs

Publikováno v: Journal of molecular graphics. 10(2)

A theoretical study was performed to elucidate the mode of interaction of the histamine H 2 -agonist dimaprit with the histamine H 2 -receptor. For this purpose receptor mapping techniques, including ab initio energy calculations, geometry optimizati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817c8bb706a14dee5123fc87bf225f1d
https://pubmed.ncbi.nlm.nih.gov/1386250

Mechanisms of activation of phenacetin to reactive metabolites by cytochrome P-450: a theoretical study involving radical intermediates

Autor: L, Koymans, J H, Van Lenthe, G M, Donné-op Den Kelder, N P, Vermeulen

Publikováno v: Molecular pharmacology. 37(3)

The cytochrome P-450-mediated activation of phenacetin (PHEN) to reactive intermediates by two hypothetical mechanisms has been studied by use of SV 6-31G ab initio energy and spin distribution calculations. In our calculations, the cytochrome P-450

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12e8867f0bc4f429154eeef6dad0026f
https://pubmed.ncbi.nlm.nih.gov/2314392

Abstracts of papers Medicinal chemistry meeting

Autor: M. G. Darlison, A. N. Bateson, R. J. Harvey, W. Wisden, E. A. Barnard, H. Loosfelt, M. Atger, A. Gulochon-Mantel, M. Misrahi, M. Perrot-Applanat, M. T. Vu Hai, F. Lorenzo, E. Milgrom, Chris J. van Koppen, Neil M. Nathanson, J. D. Naber, J. J. S. van Rensen, A. Baarslag, L. Koymans, G. M. Donné -Op den Keider, N. P. E. Vermeiden, P. P. Kelder, N. J. de Mol, L. A. 't Han, L. H. M. Janssen, S. P. van Helden, H. W. Hilbers, M. J. van Prooge, A. C. A. Jansen, L. H. M. Jansen, Anja Garritsen, Ad P. Jzerman, Margot W. Beukers, Willem Soudijn, LAGM vd Brock, Z. Zylicz, H. Hofs, D. J. Th. Wagener, J. P. G. Ballesta, P. Lelieveld, HCJ Ottenheijm, I. den Daas, P. G. Tepper, D. I. Mastebroek-Helder, A. S. Horn, W. Timmerman, B. G. J. Bohus, Durk Dijkstra, Swier Copinga, Jan B. de Vries, Sjaak den Daas, Alan S. Horn, P. N. Span, B. G. Quik, K. J. H. van Buuren, D. M. J. Veenstra, S. C. M. Levering, B. Rademaker, C. G. Huisman, M. de Boer, E. E. Moret, J. J. M. Holthuis, R. J. Driebergen, P. N. Reinhoudt, W. Verboom, A. A. van Til, F. B. van Duijneveldt, W. Vleeming, A. Stam, E. P. Bleuel, H. H. van Roolj, J. Wemer, A. J. Porsius, J. Riezebos, D. J. de Wildt, W. Vieeming, H. H. van Rooij, J. de Jong, P. R. Schopfs, R. C. A. Onderwater, H. M. Pinedo, W. J. F. van der Vijgh, A. Bast, J. F. de Vlieger, C. I. A. Doelman, M. M. Brozius, R. Leurs, H. Timmerman, M. J. Smit, A. van der Vliet, Marcel A. H. de Zwart, Henricus M. M. Bastianns, Deborah Brouwer, Henk van der Goot, Hendrik Timmerman, S. Ciere, G. R. M. M. Haenen, J. Ch. Eriks, S. A. van Acker, L. Kovmans, G. M. Donné -Op den Kelder, N. P. E. Vermeulcn, A. R. Goeptar, J. M. te Koppele, N. P. E. Vermeulen, E. P. A. Neve, G. J. Stijnties, J. M. te Koppete, N. P. F. Vermeulen, I. M. Pirovano, A. P. Ijzerman, A. M. van Rhee, W. Soudijn, C. J. Witmans, C. J. Grol, W. G. J. HoL, C. Verlinde, F. R. Opperdoes

Publikováno v: Pharmaceutisch Weekblad. 11:M1-M12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16df7f21aeb41e194ae5570dc933463c
https://doi.org/10.1007/bf02196049