Zobrazeno 1 - 10 of 59 pro vyhledávání: '"G. M. COPPOLA"'
1
In Vitro Metabolism of N-(5-Chloro-2-methylphenyl)-N‘-(2-methylpropyl)thiourea: Species Comparison and Identification of a Novel Thiocarbamide−Glutathione Adduct
Autor: K. Hitchcock, Michael J. Shapiro, G. M. Coppola, Y. K. Wang, Jefferson Chin, G. J. Stevens, S. Suwanrumpha, B. L. K. Mangold, R. W. Versace
Publikováno v: Chemical Research in Toxicology. 10:733-741
The in vitro metabolism of SDZ HDL 376, a thiocarbamide developed for the treatment of atherosclerosis, was investigated in rat, dog, monkey, and human liver microsomes, as well as in rat and human liver slices. [14C]SDZ HDL 376 was extensively metab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94671db215c804e9c3278778e1798ba6
https://doi.org/10.1021/tx9700230
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9
Secondary amides of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase
Autor: T D, Aicher, R C, Anderson, J, Gao, S S, Shetty, G M, Coppola, J L, Stanton, D C, Knorr, D M, Sperbeck, L J, Brand, C C, Vinluan, E L, Kaplan, C J, Dragland, H C, Tomaselli, A, Islam, R J, Lozito, X, Liu, W M, Maniara, W S, Fillers, D, DelGrande, R E, Walter, W R, Mann
Publikováno v: Journal of medicinal chemistry. 43(2)
N'-methyl-N-(4-tert-butyl-1,2,5,6-tetrahydropyridine)thiourea, SDZ048-619 (1), is a modest inhibitor (IC(50) = 180 microM) of pyruvate dehydrogenase kinase (PDHK). In an optimization of the N-methylcarbothioamide moiety of 1, it was discovered that a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b1772832e8ae976302ee3c02cf1e34f5
https://pubmed.ncbi.nlm.nih.gov/10649979
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