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Amyloid β-peptides inhibit Na/K-ATPase: tissue slices versus primary cultures

Autor: C. P. Smith, A. Giovanni, G. M. Bores, F Wirtz-Brugger

Publikováno v: Brain Research Bulletin. 46:423-427

Abeta1-40 (20 microM) has been reported to selectively inhibit Na+/K+-ATPase activity in rat primary hippocampal cultures after 2-6 days of exposure. We expanded these studies to include Abeta's effects on Na+/K+-ATPase activity in rat primary cortic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2998803b59cb1bbf29c5c3c4493bea
https://doi.org/10.1016/s0361-9230(97)00382-1

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Anti-Obsessional and Antidepressant Profile of Besipirdine

Autor: Lawrence L. Martin, Douglas K. Rush, J. E. Roehr, J. T. Klein, Francis P. Huger, M. R. Szewczak, R. Corbett, A. Giovanni, Richard C. Effland, R. D. Porsolt, A. T. Woods-Kettelberger, C. P. Smith, D. J. Turk, E. M. DiLeo, G. M. Bores, S. Kongsamut

Publikováno v: CNS Drug Reviews. 3:1-23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74aa22289c43b54f05aef244161c3e30
https://doi.org/10.1111/j.1527-3458.1997.tb00313.x

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Besipirdine (HP 749) reduces schedule-induced polydipsia in rats

Autor: A. T. Woods-Kettelberger, R. Corbett, S. Kongsamut, J. T. Klein, M. R. Szewczak, G. M. Bores, C. P. Smith, J. E. Roehr

Publikováno v: Brain Research Bulletin. 41:125-130

The aim of the present paper is to report on the adrenergic and serotonergic effects of besipirdine (HP 749) in vivo and to discuss its potential use in the treatment of obsessive compulsive disorder. Besipirdine inhibited biogenic amine uptake in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7ae06f904de97fbb931843b5e8a8332
https://doi.org/10.1016/0361-9230(96)00163-3

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Pharmacological activity and safety profile of P10358, a novel, orally active acetylcholinesterase inhibitor for Alzheimer's disease

Autor: C P, Smith, G M, Bores, W, Petko, M, Li, D E, Selk, D K, Rush, F, Camacho, J T, Winslow, R, Fishkin, D M, Cunningham, K M, Brooks, J, Roehr, H B, Hartman, L, Davis, H M, Vargas

Publikováno v: The Journal of pharmacology and experimental therapeutics. 280(2)

1-[(3-Fluoro-4-pyridinyl)amino]-3-methyl-1(H)-indol-5-yl methyl carbamate (P10358) is a potent, reversible acetylcholinesterase inhibitor that produces central cholinergic stimulation after oral and parental administration in rats and mice. P10358 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5341035c9e227d7dd84b87a3631a028e
https://pubmed.ncbi.nlm.nih.gov/9023283

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Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine

Autor: G M, Bores, F P, Huger, W, Petko, A E, Mutlib, F, Camacho, D K, Rush, D E, Selk, V, Wolf, R W, Kosley, L, Davis, H M, Vargas

Publikováno v: The Journal of pharmacology and experimental therapeutics. 277(2)

Acetylcholinesterase (AChE) inhibitors from several chemical classes have been tested for the symptomatic treatment of Alzheimer's disease; however, the therapeutic success of these compounds has been limited. Recently, another AChE inhibitor, galant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::adbfcdf2868fbefad406fd3f2a33a8ca
https://pubmed.ncbi.nlm.nih.gov/8627552

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