Zobrazeno 1 - 10
of 13
pro vyhledávání: '"G. M. BOXER"'
Autor:
R B, Pedley, S A, Hill, G M, Boxer, A A, Flynn, R, Boden, R, Watson, J, Dearling, D J, Chaplin, R H, Begent
Publikováno v:
Cancer research. 61(12)
Solid tumors have a heterogeneous pathophysiology, which has a major impact on therapy. Using SW1222 colorectal xenografts grown in nude mice, we have shown that antibody-targeted radioimmunotherapy (RIT) effectively treated the well-perfused tumor r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f84ac6cf813cbb5a541afe05300c3147
https://pubmed.ncbi.nlm.nih.gov/11406542
https://pubmed.ncbi.nlm.nih.gov/11406542
Publikováno v:
Cancer research. 61(9)
Vascular endothelial growth factor (VEGF) is produced by cancer cells in response to hypoxia and is the primary stimulant of vascularization in solid tumors. Endothelial cells lining the blood vessels of these tumors have a high concentration of rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b0e066570b1d32ad7d84f80489af3e04
https://pubmed.ncbi.nlm.nih.gov/11325835
https://pubmed.ncbi.nlm.nih.gov/11325835
Autor:
A, Mayer, E, Tsiompanou, D, O'Malley, G M, Boxer, J, Bhatia, A A, Flynn, K A, Chester, B R, Davidson, A A, Lewis, M C, Winslet, A P, Dhillon, A J, Hilson, R H, Begent
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(5)
In radioimmunoguided surgery (RIGS), a radiolabeled antibody is given i.v. before surgery and a hand-held gamma-detecting probe is used to locate tumor in the operative field. The rapid blood clearance and good tumor penetration of single-chain Fv an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4db5c92dd10bd5a3aae4ed1ae6edb3df
https://pubmed.ncbi.nlm.nih.gov/10815889
https://pubmed.ncbi.nlm.nih.gov/10815889
Autor:
J, Bhatia, S K, Sharma, K A, Chester, R B, Pedley, R W, Boden, D A, Read, G M, Boxer, N P, Michael, R H, Begent
Publikováno v:
International journal of cancer. 85(4)
Antibody-directed enzyme prodrug therapy (ADEPT) targets an enzyme selectively to a tumor where it converts a relatively non-toxic prodrug to a potent cytotoxic drug. Previous clinical work using antibody-enzyme chemical conjugates has been limited b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::19e822bb225d86e7932a47146d224647
https://pubmed.ncbi.nlm.nih.gov/10699932
https://pubmed.ncbi.nlm.nih.gov/10699932
Autor:
R B, Pedley, S K, Sharma, G M, Boxer, R, Boden, S M, Stribbling, L, Davies, C J, Springer, R H, Begent
Publikováno v:
Cancer research. 59(16)
The irregular nature of solid tumor vasculature produces a heterogeneous distribution of antibody-targeted therapies within the tumor mass, which frequently results in reduced therapeutic efficacy. We have, therefore, combined two complementary thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5f3d89a9c7c53bd5936c45205630c894
https://pubmed.ncbi.nlm.nih.gov/10463598
https://pubmed.ncbi.nlm.nih.gov/10463598
Publikováno v:
Cancer research. 56(14)
Radioimmunotherapy (RIT) does not readily eradicate common solid tumors and therefore requires augmentation by complementary therapies that do not increase normal tissue damage. We have examined the efficacy of RIT combined with 5,6-dimethylxanthenon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0aefd8b46b3d058a315b63945bee7ddd
https://pubmed.ncbi.nlm.nih.gov/8764124
https://pubmed.ncbi.nlm.nih.gov/8764124
Autor:
R A, Fisher, E S, Newlands, A J, Jeffreys, G M, Boxer, R H, Begent, G J, Rustin, K D, Bagshawe
Publikováno v:
Cancer. 69(3)
In three patients in whom a diagnosis of gestational trophoblastic tumor was possible on the basis of pathology and elevated levels of serum human chorionic gonadotrophin, locus-specific minisatellite probes were used to identify restriction fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ee3f1acd7b293d1b5a8e8d0426ebb6e
https://pubmed.ncbi.nlm.nih.gov/1346098
https://pubmed.ncbi.nlm.nih.gov/1346098
Publikováno v:
Diseases of the colon and rectum. 34(3)
Radioimmunoguided surgery (RIGS) using an anti-CEA (A5B7) monoclonal antibody has been assessed in 52 patients (43 primary excisions and nine second look procedures) undergoing surgery for colorectal carcinoma. The antibody localized in 97.8 percent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968f0c9bfc529ec2e5bfcf8f00527f82
https://pubmed.ncbi.nlm.nih.gov/1999127
https://pubmed.ncbi.nlm.nih.gov/1999127
Publikováno v:
Lancet (London, England). 335(8697)
11 patients registered with an initial diagnosis of partial hydatidiform mole (PHM) subsequently required chemotherapy for a gestational trophoblastic tumour. In a retrospective review by histopathological examination and measurement of DNA ploidy, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2f0f016bb9137511ffc662c9e051d6
https://pubmed.ncbi.nlm.nih.gov/1970378
https://pubmed.ncbi.nlm.nih.gov/1970378
Publikováno v:
British Journal of Cancer
A method of epitope analysis is described in which the binding of one monoclonal antibody (MAb) to radiolabeled carcinoembryonic antigen (CEA) competes with the subsequent binding of an immobilised second MAb. From the degree of blocking obtained, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cc6f922e28d8a6b868e67a8535458d
https://doi.org/10.1038/bjc.1986.154
https://doi.org/10.1038/bjc.1986.154