Zobrazeno 1 - 10
of 121
pro vyhledávání: '"G. M. BLACKBURN"'
Autor:
George W. Mobbs, Adli A. Aziz, Samuel R. Dix, G. M. Blackburn, Sveta E. Sedelnikova, Thomas C. Minshull, Mark J. Dickman, Patrick J. Baker, Sheila Nathan, Mohd Firdaus Raih, David W. Rice
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
The crystal structure of the toxin from the pathogenic bacterium Burkholderia pseudomallei in complex with its target, human eIF4A, provides insights into substrate specificity and may facilitate the design of inhibitors for the treatment of melioido
Externí odkaz:
https://doaj.org/article/e58c27ff57b144fda8009caa288cd49d
Publikováno v:
Nucleic Acids in Chemistry and Biology ISBN: 9781788019040
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fa3c157528f7d2dd41d2b85754b8cef
https://doi.org/10.1039/9781837671328-00627
https://doi.org/10.1039/9781837671328-00627
Autor:
George W, Mobbs, Adli A, Aziz, Samuel R, Dix, G M, Blackburn, Sveta E, Sedelnikova, Thomas C, Minshull, Mark J, Dickman, Patrick J, Baker, Sheila, Nathan, Mohd Firdaus, Raih, David W, Rice
Publikováno v:
Communications biology. 5(1)
Burkholderia pseudomallei lethal factor 1 (BLF1) exhibits site-specific glutamine deamidase activity against the eukaryotic RNA helicase, eIF4A, thereby blocking mammalian protein synthesis. The structure of a complex between BLF1 C94S and human eIF4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::713f307d2e53475df64fd53d0052c6ae
https://pubmed.ncbi.nlm.nih.gov/35347220
https://pubmed.ncbi.nlm.nih.gov/35347220
Metal fluoride complexes mimic the transferring phosphoryl group in many enzyme-catalyzed reactions. We here employ the trifluoromagnesate transition state analog (TSA) to study a Zika virus NS3h helicase, which uses energy from ATP hydrolysis to reo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62efeb62df8e143d72fedc830ed5454c
https://doi.org/10.26434/chemrxiv.11908401.v1
https://doi.org/10.26434/chemrxiv.11908401.v1
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 191:367-372
Tetraalkyl 1,1,3,3-tetrafluoro-2,2-dihydroxypropane-1,3-bisphosphonates were prepared. The complex 31P{1H}- and 19F-NMR spectra were analyzed as [[A]2X]2 and related systems. Modern methods of auto...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::badc6122ea809e9d680e8d3e0f127e5d
https://doi.org/10.1080/10426507.2015.1073281
https://doi.org/10.1080/10426507.2015.1073281
Publikováno v:
Biochemistry (Moscow). 77:1083-1096
Early studies on chemical synthesis of biological molecules can be seen to progress to preparation and biological evaluation of phosphonates as analogues of biological phosphates, with emphasis on their isosteric and isopolar character. Work with suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904c0814b7047f6a743b859c06d8c682
https://doi.org/10.1134/s000629791210001x
https://doi.org/10.1134/s000629791210001x
Bisphosphonates Are Incorporated into Adenine Nucleotides by Human Aminoacyl-tRNA Synthetase Enzymes
Publikováno v:
Biochemical and Biophysical Research Communications. 224:863-869
Bisphosphonates are synthetic pyrophosphate analogues and are therapeutic inhibitors of bone resorption, although their exact mechanisms of action are unclear. Some bisphosphonates can be metabolised into non-hydrolysable ATP analogues by Dictyosteli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df65918186f1b0bd17503e33755cff5
https://doi.org/10.1006/bbrc.1996.1113
https://doi.org/10.1006/bbrc.1996.1113
Publikováno v:
Collection of Czechoslovak Chemical Communications. 61:88-91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd17ab39897ac215ba9d5b9edcb729e0
https://doi.org/10.1135/cccc1996s088
https://doi.org/10.1135/cccc1996s088
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2573-2578
Phosphonate analogues of 1,3- bis phosphoglyceric acid, several incorporating non-scissile α-difluoro phosphonates, have been synthesised and their binding to phosphoglycerate kinase measured by NMR analysis. The tetrafluoroamide analogue ( 4 ) of 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::398c55fb262f053d66f9b28be11473bc
https://doi.org/10.1016/s0960-894x(01)80286-9
https://doi.org/10.1016/s0960-894x(01)80286-9
Publikováno v:
Biochemistry. 33:235-240
The different patterns of enzymatic cleavage of diadenosine polyphosphates, ApnAs, where n = 3-5, have been established by fast atom bombardment mass spectrometry, FAB MS, of the nucleotide products formed in the presence of H2(18)O. The three specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3969758bfbbd18dd6937f9d764f909
https://doi.org/10.1021/bi00167a031
https://doi.org/10.1021/bi00167a031