Zobrazeno 1 - 10
of 260
pro vyhledávání: '"G. Lunde"'
Autor:
Karoline B. Rypdal, A. Olav Melleby, Emma L. Robinson, Jia Li, Sheryl Palmero, Deborah E. Seifert, Daniel Martin, Catelyn Clark, Begoña López, Kristine Andreassen, Christen P. Dahl, Ivar Sjaastad, Theis Tønnessen, Mathis K. Stokke, William E. Louch, Arantxa González, Stephane Heymans, Geir Christensen, Suneel S. Apte, Ida G. Lunde
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
The role of ADAMTSL3 in heart pathology and cardiac disease is investigated with Adamtsl3-deficient mice using CRISPR-Cas9 gene editing.
Externí odkaz:
https://doaj.org/article/8dc2cdb39a0043879864fac9c8cf91a5
Autor:
Karoline B. Rypdal, Pugazendhi M. Erusappan, A. Olav Melleby, Deborah E. Seifert, Sheryl Palmero, Mari E. Strand, Theis Tønnessen, Christen P. Dahl, Vibeke Almaas, Dirk Hubmacher, Suneel S. Apte, Geir Christensen, Ida G. Lunde
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Fibrosis accompanies most heart diseases and is associated with adverse patient outcomes. Transforming growth factor (TGF)β drives extracellular matrix remodelling and fibrosis in the failing heart. Some members of the ADAMTSL (a disintegri
Externí odkaz:
https://doaj.org/article/ce2aba904d844c0083d6fbfea2ad66f8
Autor:
Mari E. Strand, Maarten Vanhaverbeke, Michiel T. H. M. Henkens, Maurits A. Sikking, Karoline B. Rypdal, Bjørn Braathen, Vibeke M. Almaas, Theis Tønnessen, Geir Christensen, Stephane Heymans, Ida G. Lunde
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1066 (2023)
Circulating biomarkers reflecting cardiac inflammation are needed to improve the diagnostics and guide the treatment of heart failure patients. The cardiac production and shedding of the transmembrane proteoglycan syndecan-4 is upregulated by innate
Externí odkaz:
https://doaj.org/article/514b3671c1284d8284e556e1b714e1e8
Autor:
Kristine Andreassen, Chloe Rixon, Marie H. Hansen, Ida Marie Hauge-Iversen, Lili Zhang, Mani Sadredini, Pugazendhi M. Erusappan, Ivar Sjaastad, Geir Christensen, Kristina H. Haugaa, Thor Edvardsen, Ida G. Lunde, Mathis K. Stokke
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 324:H881-H892
Genotype-positive hypertrophic cardiomyopathy (HCM) mice had beneficial effects of exercise initiated before phenotype development. Exercised HCM mice had increased exercise capacity, smaller left atria, no increase in hypertrophy, or reduction of fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68adb6530d88914e0be95eb777daff45
https://doi.org/10.1152/ajpheart.00701.2022
https://doi.org/10.1152/ajpheart.00701.2022
Autor:
Kate M. Herum, Andreas Romaine, Ariel Wang, Arne Olav Melleby, Mari E. Strand, Julian Pacheco, Bjørn Braathen, Pontus Dunér, Theis Tønnessen, Ida G. Lunde, Ivar Sjaastad, Cord Brakebusch, Andrew D. McCulloch, Maria F. Gomez, Cathrine R. Carlson, Geir Christensen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 3 (2020)
Background Pressure overload of the heart occurs in patients with hypertension or valvular stenosis and induces cardiac fibrosis because of excessive production of extracellular matrix by activated cardiac fibroblasts. This initially provides essenti
Externí odkaz:
https://doaj.org/article/0922edaba2a44a418bd03e18dfab768b
Autor:
Kristine Andreassen, Lars A. Dejgaard, Øyvind Lie, Trine S. Fink, Ida G. Lunde, Thor Edvardsen, Kristina H. Haugaa, Mathis K. Stokke
Publikováno v:
International Journal of Cardiology. 364:65-71
Background Diastolic dysfunction is an important part of the clinical phenotype in hypertrophic cardiomyopathy (HCM). While exercise training is known to improve left ventricular (LV) diastolic function in normal hearts, the effects of exercise train
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a017aac549a1efe94168db645d2a9fb
https://doi.org/10.1016/j.ijcard.2022.06.042
https://doi.org/10.1016/j.ijcard.2022.06.042
Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
Autor:
Aurelija Abraityte, Ida G. Lunde, Erik T. Askevold, Annika E. Michelsen, Geir Christensen, Pål Aukrust, Arne Yndestad, Arnt Fiane, Arne Andreassen, Svend Aakhus, Christen P. Dahl, Lars Gullestad, Kaspar Broch, Thor Ueland
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract The Wingless (Wnt) pathway has been implicated in the pathogenesis of dilated cardiomyopathy (DCM). To explore the role of Wnt modulators Wnt5a and sFRP3 in DCM patients we analyzed the expression of Wnt5a and sFRP3 in plasma and myocardium
Externí odkaz:
https://doaj.org/article/572165425058480c879552c9e58ac6e1
Autor:
Andreas Romaine, Arne Olav Melleby, Jahedul Alam, Viola Hélène Lobert, Ning Lu, Francesca E. Lockwood, Almira Hasic, Ida G. Lunde, Ivar Sjaastad, Harald Stenmark, Kate M. Herum, Donald Gullberg, Geir Christensen
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 322:H1057-H1071
Pathological myocardial hypertrophy in response to an increase in left ventricular (LV) afterload may ultimately lead to heart failure. Cell surface receptors bridge the interface between the cell and the extracellular matrix (ECM) in cardiac myocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aefab05e9f227da3a5490c520d67668
https://doi.org/10.1152/ajpheart.00635.2021
https://doi.org/10.1152/ajpheart.00635.2021
Autor:
Sophie L.V.M. Stroeks, Ida G. Lunde, Debby M.E.I. Hellebrekers, Godelieve R.F. Claes, Hiroko Wakimoto, Joshua Gorham, Ingrid P.C. Krapels, Els K. Vanhoutte, Arthur van den Wijngaard, Michiel T.H.M. Henkens, Anne G. Raafs, Maurits A. Sikking, Jos L.V. Broers, Miranda Nabben, Elizabeth A.V. Jones, Stephane R.B. Heymans, Han G. Brunner, Job A.J. Verdonschot
Publikováno v:
Circulation. Genomic and Precision Medicine, 16, 2
Circulation. Genomic and Precision Medicine, 16
Circulation. Genomic and Precision Medicine, 16
Background: Dilated cardiomyopathy (DCM) was considered a monogenetic disease that can be caused by over 60 genes. Evidence suggests that the combination of multiple pathogenic variants leads to greater disease severity and earlier onset. So far, not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb94c3a2c1bb818301f92ecf7b5f346f
https://doi.org/10.1161/CIRCGEN.122.003788
https://doi.org/10.1161/CIRCGEN.122.003788
Autor:
Kine Andenæs, Ida G Lunde, Naiyereh Mohammadzadeh, Christen P Dahl, Jan Magnus Aronsen, Mari E Strand, Sheryl Palmero, Ivar Sjaastad, Geir Christensen, Kristin V T Engebretsen, Theis Tønnessen
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201422 (2018)
Pressure overload of the heart leads to cardiac remodeling that may progress into heart failure, a common, morbid and mortal condition. Increased mechanistic insight into remodeling is instrumental for development of novel heart failure treatment. Ca
Externí odkaz:
https://doaj.org/article/d6548e337d7d4de287ebce437f1298b6