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Publikováno v:
British Journal of Haematology. 120:36-43
Summary. We previously showed that serum beta-2-microglobulin (β2m)-free human leucocyte antigen (HLA) class I heavy chain (FHC) levels were increased in MM and correlate with disease activity. The present investigation, carried out in 124 multiple
Publikováno v:
European Journal of Immunogenetics. 29:409-412
Summary No monoclonal antibodies (mAbs) are presently available to measure the total amount of β2-microglobulin-free HLA class I heavy chain (FHC) in sera. The available ELISA-based double determinant immunoassay (DDIA), established to measure FHC,
Autor:
Federico Perosa, G Luccarelli, Marco Scudeletti, Maurizio Cutolo, Franco Dammacco, F. Indiveri
Publikováno v:
Journal of Clinical Immunology. 22:13-22
We have analyzed the immune response elicited with the human CD4 internal antigen anti-idiotypic monoclonal antibody 16D7 in four patients with active systemic lupus erythematosus and assessed the safety of the treatment. Patients 1 and 2 received th
Publikováno v:
British Journal of Haematology. 106:987-994
Serum levels of β2-microglobulin (β2m)-free HLA class I heavy chain (FHC) in 94 patients with multiple myeloma (MM) were higher than in 29 patients with monoclonal gammopathy of undetermined significance (MGUS) (P = 0.023) and in 97 sex- and age-ma
Publikováno v:
International Journal of Clinical and Laboratory Research. 28:246-251
Biotinylated lymphoid cells have been suggested as a useful source of antigen for the immunochemical characterization of their molecular profile. Labelling with biotin eliminates the problems associated with the use of radioactivity. However, this me
Publikováno v:
Journal of Immunological Methods. 203:153-155
Seven out of ten Fab (F(ab')2/Fab') preparations derived from purified human myeloma IgG showed a substantial binding to protein G-Sepharose. Subclass analysis revealed that the 7 protein G-reactive Fabs included 3 IgG1, 2 IgG3 and 2 IgG4 Fabs, where
Autor:
Soldano Ferrone, Elvira Favoino, Franco Dammacco, Federico Perosa, G Luccarelli, Marcella Prete
Publikováno v:
Scopus-Elsevier
mAb HC-10 loses its reactivity with HLA class I (HLA-I) H chain (HC) following its association with β2-microglobulin (β2m). Furthermore, the HC-10 defined epitope appears to be involved in the pathogenesis of spondyloarthropathies, because HC-10 re
Publikováno v:
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics. 29(5)
No monoclonal antibodies (mAbs) are presently available to measure the total amount of beta2-microglobulin-free HLA class I heavy chain (FHC) in sera. The available ELISA-based double determinant immunoassay (DDIA), established to measure FHC, uses t
Publikováno v:
Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna. 16(4)
The present report critically reviews the rationale, clinical effectiveness and limits of monoclonal antibody-based immunotherapy in the treatment of autoimmune diseases, with particular emphasis on tumor necrosis factor-alpha blocking reagents. Refe