Adenovirus mediated gene transfer in organotypic brain slices

Autor: V. Ridoux, J.-J. Robert, M. Perricaudet, J. Mallet, G. Le Gal La Salle

Publikováno v: Neurobiology of Disease, Vol 2, Iss 1, Pp 49-54 (1995)

A replication-defective adenovirus vector carrying the reporter gene encoding β-galactosidase was used to transfect organotypic slices maintained in culture for up to 1 month. Three different delivery systems were used to inoculate the viral solutio

Externí odkaz: https://doaj.org/article/50c0210d0d5b4cf598885c3aec49142a

Adenovirus-mediated transfer of a functional GAD gene into nerve cells: potential for the treatment of neurological diseases

Autor: JJ Robert, V Bouilleret, V Ridoux, A Valin, MC Geoffroy, J Mallet, G Le Gal La Salle

Publikováno v: Gene Therapy
Gene Therapy, Nature Publishing Group, 1997, 4 (11), pp.1237-1245. ⟨10.1038/sj.gt.3300521⟩

The recent development of efficient virus-mediated gene transfer into nerve cells allows the prospect of new strategies for the treatment of drug-resistant neurological diseases. Some forms of epilepsy may be amenable to gene therapy. Although there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27aa428492ae167dfb01228b679ef51
https://doi.org/10.1038/sj.gt.3300521

Immunological identification of a new 14X10(3) Mr membrane-bound protein in Torpedo electric organ

Autor: N. Morel, G. Brochier, M. Synguelakis, G. Le Gal La Salle

Publikováno v: Journal of Cell Science. 98:351-361

A series of monoclonal antibodies binding to different epitopes shared by a 14 × 10(3)Mr membrane-bound polypeptide has been obtained. By indirect immuno-fluorescence, it was shown that the 14 × 10(3)Mr antigen is present in various cell types in T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba88f129e480f9b7b626de702f8f1ca
https://doi.org/10.1242/jcs.98.3.351

Patterns of dentate granule cell responses to perforant path stimulation in epileptic mice with granule cell dispersion

Autor: A. Rougier, S. Arthaud, N. Zombre, G. Le Gal La Salle

Publikováno v: Epilepsy research. 63(2-3)

In adult mice, intrahippocampal administration of kainic acid induces a structural modification of the granule cell layer reminiscent of granule cell dispersion (GCD) seen in humans with temporal lobe epilepsy. We tested that GCD might be involved in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f0ee8ce699a617f54ae57c1adcfbb0
https://pubmed.ncbi.nlm.nih.gov/15777666

Efficient gene transfer and long-term expression in neurons using a recombinant adenovirus with a neuron-specific promoter

Autor: V Navarro, S Millecamps, M-C Geoffroy, J-J Robert, A Valin, J Mallet, G Le Gal La Salle

Publikováno v: Gene Therapy
Gene Therapy, Nature Publishing Group, 1999, 6 (11), pp.1884-1892. ⟨10.1038/sj.gt.3301008⟩
Gene Therapy, 1999, 6 (11), pp.1884-1892. ⟨10.1038/sj.gt.3301008⟩

International audience; Adenoviruses are highly efficient vectors for gene transfer into brain cells. Restricting transgene expression to specific cell types and maintaining long-term expression are major goals for gene therapy in the central nervous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c863aa91f7b077d9ccf0f061933dbfc
https://hal-cnrs.archives-ouvertes.fr/hal-03083409