Zobrazeno 1 - 10 of 27 pro vyhledávání: '"G. L. Semenza"'
1
Hypoxia-Inducible Factors in Cancer
Autor: H, Zhong, A M, De Marzo, E, Laughner, M, Lim, D A, Hilton, D, Zagzag, P, Buechler, W B, Isaacs, G L, Semenza, J W, Simons
Publikováno v: Cancer Res
Neovascularization and increased glycolysis, two universal characteristics of solid tumors, represent adaptations to a hypoxic microenvironment that are correlated with tumor invasion, metastasis, and lethality. Hypoxia-inducible factor 1 (HIF-1) act
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe45ecd37f1401e2de9ca4a0a0d2fce
https://doi.org/10.1158/0008-5472.can-21-3780
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2
HIF-1-dependent Expression of Angiopoietin-like 4 and L1CAM Mediates Vascular Metastasis of Hypoxic Breast Cancer Cells to the Lungs
Autor: H, Zhang, C C L, Wong, H, Wei, D M, Gilkes, P, Korangath, P, Chaturvedi, L, Schito, J, Chen, B, Krishnamachary, P T, Winnard, V, Raman, L, Zhen, W A, Mitzner, S, Sukumar, G L, Semenza
Publikováno v: Oncogene
Most cases of breast cancer mortality are due to vascular metastasis. Breast cancer cells must intravasate through endothelial cells (ECs) to enter a blood vessel in the primary tumor and then adhere to ECs and extravasate at the metastatic site. In
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a70c0e58e0206144f52a05bbf864562a
http://europepmc.org/articles/PMC3223555
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3
'The metabolism of tumours': 70 years later
Autor: G L, Semenza, D, Artemov, A, Bedi, Z, Bhujwalla, K, Chiles, D, Feldser, E, Laughner, R, Ravi, J, Simons, P, Taghavi, H, Zhong
Publikováno v: Novartis Foundation symposium. 240
Otto Warburg's classic treatise on the reprogramming of tumour metabolism from oxidative to glycolytic metabolism was published in London in 1930. Although the Warburg effect is one of the most universal characteristics of solid tumours, the molecula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef3ebeb4361d436b6ee63450a2494215
https://pubmed.ncbi.nlm.nih.gov/11727934
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4
HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus
Autor: G L, Semenza
Publikováno v: Cell. 107(1)
Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O(2) homeostasis in animals. A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in ge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc25316dca48e0bfe8738ef4c723593f
https://pubmed.ncbi.nlm.nih.gov/11595184
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5
Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms
Autor: Z, Dong, M A, Venkatachalam, J, Wang, Y, Patel, P, Saikumar, G L, Semenza, T, Force, J, Nishiyama
Publikováno v: The Journal of biological chemistry. 276(22)
Hypoxia is a key determinant of tissue pathology during tumor development and organ ischemia. However, little is known regarding hypoxic regulation of genes that are directly involved in cell death or death resistance. Here we report the striking ind
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4791aff1a6a4aacec2180491d4fa489b
https://pubmed.ncbi.nlm.nih.gov/11278985
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6
HIF-1: using two hands to flip the angiogenic switch
Autor: G L, Semenza
Publikováno v: Cancer metastasis reviews. 19(1-2)
In brain, breast, and other common human tumors there is a correlation between expression of the transcriptional activator hypoxia-inducible factor 1 (HIF-1) and tumor grade and vascularization. HIF-1 stimulates angiogenesis by activating transcripti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee5285c200d4ab0521e337b6fce17188
https://pubmed.ncbi.nlm.nih.gov/11191064
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7
Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain
Autor: M, Bergeron, J M, Gidday, A Y, Yu, G L, Semenza, D M, Ferriero, F R, Sharp
Publikováno v: Annals of neurology. 48(3)
Hypoxia-inducible factor-1 (HIF-1) is a heterodimer composed of HIF-1alpha and HIF-1beta protein subunits. This transcription factor is essential for the activation of hypoxia-inducible genes like erythropoietin, some glucose transporters, the glycol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29af0b338a77fca4904974f33aa01e2d
https://pubmed.ncbi.nlm.nih.gov/10976634
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9
Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression
Autor: D, Zagzag, H, Zhong, J M, Scalzitti, E, Laughner, J W, Simons, G L, Semenza
Publikováno v: Cancer. 88(11)
Hypoxia inducible factor-1 (HIF-1) plays a critical role in angiogenesis during vascular development. The authors tested the hypothesis that HIF-1 expression correlates with progression and angiogenesis in brain tumors.The authors investigated the ex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b34f382e2ed2f6d8e64379a48e3f228
https://pubmed.ncbi.nlm.nih.gov/10861440
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10
Chairman's summary: mechanisms of oxygen homeostasis, circa 1999
Autor: G L, Semenza
Publikováno v: Advances in experimental medicine and biology. 475
Oxygen sensing is a fundamental physiologic requirement of all living organisms and all cells within the human body. This paper presents a brief summary of recent investigations into the molecular mechanisms underlying oxygen sensing and adaptive res
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3967a100a3007be17948a073e8ea477a
https://pubmed.ncbi.nlm.nih.gov/10849671
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