Hypoxia-Inducible Factors in Cancer

Autor: H, Zhong, A M, De Marzo, E, Laughner, M, Lim, D A, Hilton, D, Zagzag, P, Buechler, W B, Isaacs, G L, Semenza, J W, Simons

Publikováno v: Cancer Res

Neovascularization and increased glycolysis, two universal characteristics of solid tumors, represent adaptations to a hypoxic microenvironment that are correlated with tumor invasion, metastasis, and lethality. Hypoxia-inducible factor 1 (HIF-1) act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe45ecd37f1401e2de9ca4a0a0d2fce
https://doi.org/10.1158/0008-5472.can-21-3780

HIF-1-dependent Expression of Angiopoietin-like 4 and L1CAM Mediates Vascular Metastasis of Hypoxic Breast Cancer Cells to the Lungs

Autor: H, Zhang, C C L, Wong, H, Wei, D M, Gilkes, P, Korangath, P, Chaturvedi, L, Schito, J, Chen, B, Krishnamachary, P T, Winnard, V, Raman, L, Zhen, W A, Mitzner, S, Sukumar, G L, Semenza

Publikováno v: Oncogene

Most cases of breast cancer mortality are due to vascular metastasis. Breast cancer cells must intravasate through endothelial cells (ECs) to enter a blood vessel in the primary tumor and then adhere to ECs and extravasate at the metastatic site. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a70c0e58e0206144f52a05bbf864562a
http://europepmc.org/articles/PMC3223555

Thermosensitive Hydrogel with Programmable, Self‐Regulated HIF‐1α Stabilizer Release for Myocardial Infarction Treatment.

Autor: Deng, Kaicheng^1,2 (AUTHOR), Hua, Yuyan² (AUTHOR), Gao, Ying^1,3 (AUTHOR), Zheng, Houwei² (AUTHOR), Jiang, Yangzi^4,5 (AUTHOR), Wang, Yaping^1,3 (AUTHOR), Gao, Changyou^1,2 (AUTHOR) cygao@zju.edu.cn, Ren, Tanchen^1,3 (AUTHOR) rentanchen120@zju.edu.cn, Zhu, Yang^1,2,6 (AUTHOR) zhuyang@zju.edu.cn

Publikováno v: Advanced Science. 11/20/2024, Vol. 11 Issue 43, p1-13. 13p.

Circulating Tumor Cells Culture: Methods, Challenges, and Clinical Applications.

Autor: Zhou Z; Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Shenzhen Futian Research Institute, Shenzhen, 518057, China.; Department of Biomedical Sciences, Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong SAR, 999077, China.; Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China., Cai S; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, China., Zhou X; Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Shenzhen Futian Research Institute, Shenzhen, 518057, China.; Department of Biomedical Sciences, Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong SAR, 999077, China.; Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China., Zhao W; Department of Biomedical Sciences, Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong SAR, 999077, China., Sun J; Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Shenzhen Futian Research Institute, Shenzhen, 518057, China.; Department of Biomedical Sciences, Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong SAR, 999077, China., Zhou Z; Department of Biomedical Sciences, Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong SAR, 999077, China., Yang Z; Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Shenzhen Futian Research Institute, Shenzhen, 518057, China.; Department of Biomedical Sciences, Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong SAR, 999077, China., Li W; Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Shenzhen Futian Research Institute, Shenzhen, 518057, China.; Department of Biomedical Sciences, Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong SAR, 999077, China., Wang Z; The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, 510080, China., Zou H; Cellomics (Shenzhen) Limited, Shenzhen, 518118, China., Fu H; Cellomics (Shenzhen) Limited, Shenzhen, 518118, China., Wang X; The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, 510080, China., Khoo BL; Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Shenzhen Futian Research Institute, Shenzhen, 518057, China.; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China., Yang M; Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Shenzhen Futian Research Institute, Shenzhen, 518057, China.; Department of Biomedical Sciences, Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong SAR, 999077, China.; Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China.

Publikováno v: Small methods [Small Methods] 2024 Dec 27, pp. e2401026. Date of Electronic Publication: 2024 Dec 27.

Hypoxia Induced Lnc191 Upregulation Dictates the Progression of Esophageal Squamous Cell Carcinoma by Activating GRP78/ERK Pathway.

Autor: Wei S; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.; Research Center, the Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, Clinical Oncology Research Center, Shijiazhuang, Hebei, 050011, China., Fan X; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China., Li X; Research Center, the Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, Clinical Oncology Research Center, Shijiazhuang, Hebei, 050011, China., Zhou W; Hangzhou Institute of Medicine, University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, 310022, China., Zhang Z; Neurosurgery Department, Tsinghua University Yuquan Hospital, Beijing, 100049, China., Dai S; Research Center, the Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, Clinical Oncology Research Center, Shijiazhuang, Hebei, 050011, China., Lv H; Department of Thoracic Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China., Liu Y; Pathology Department, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China., Shan B; Research Center, the Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, Clinical Oncology Research Center, Shijiazhuang, Hebei, 050011, China., Zhao L; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.; Research Center, the Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, Clinical Oncology Research Center, Shijiazhuang, Hebei, 050011, China., Zhan Q; Key Laboratory of Carcinogenesis and Translational Research, Laboratory of Molecular Oncology, Peking University Cancer Hospital & Institute, Beijing, 100142, China., Song Y; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Dec 04, pp. e2406674. Date of Electronic Publication: 2024 Dec 04.