Zobrazeno 1 - 9
of 9
pro vyhledávání: '"G. L. Lokesh"'
Publikováno v:
Analytical Biochemistry. 411:254-260
The casitas B-lineage lymphoma (Cbl) proteins play an important role in regulating signal transduction pathways by functioning as E3 ubiquitin ligases. The Cbl proteins contain a conserved tyrosine kinase binding (TKB) domain that binds more than a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857ce4f9b9c842da432e25ea472afb0d
https://doi.org/10.1016/j.ab.2010.11.038
https://doi.org/10.1016/j.ab.2010.11.038
Autor:
Prem Raj B. Joseph, Smitha Kizhake, Krishna Rajarathnam, Amarnath Natarajan, Ziyan Yuan, Eric A. Kumar, G. L. Lokesh
Publikováno v:
Biochemical and Biophysical Research Communications. 393:207-210
BRCT(BRCA1) plays a major role in DNA repair pathway, and does so by recognizing the conserved sequence pSXXF in its target proteins. Remarkably, tetrapeptides containing pSXXF motif bind with high specificity and micromolar affinity. Here, we have c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a185654991c83ff4effbd7308b1155f
https://doi.org/10.1016/j.bbrc.2010.01.098
https://doi.org/10.1016/j.bbrc.2010.01.098
Publikováno v:
Analytical Biochemistry. 352:135-141
The C-terminus region of the 1863 residue early onset of breast cancer gene 1 (BRCA1) nuclear protein contains a tandem globular carboxy terminus domain termed BRCT. The BRCT repeats in BRCA1 are phosphoserine- and/or phosphothreonine-specific bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fd7ffc9a3e8d0029cd59f17c9f62bd
https://doi.org/10.1016/j.ab.2006.01.025
https://doi.org/10.1016/j.ab.2006.01.025
Autor:
Nicholas Y. Palermo, Smitha Kizhake, G. L. Lokesh, Gulzar Ahmad, Hamid Band, Gloria E. O. Borgstahl, Lin Dong, Ziyan Yuan, Amarnath Natarajan, Carol Kolar, Eric A. Kumar
We describe truncation and SAR studies to identify a pentapeptide that binds Cbl tyrosine kinase binding domain with a higher affinity than the parental peptide. The pentapeptide has an alternative binding mode that allows occupancy of a previously u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91344fc77232f8600c134a6ea329cb65
https://europepmc.org/articles/PMC3325325/
https://europepmc.org/articles/PMC3325325/
Autor:
Estrella-Jimenez Maria, Matthew J. Shashack, Pedro M. J. Lory, G. L. Lokesh, Scott R. Gilbertson, Amarnath Natarajan
Publikováno v:
ChemInform. 39
This manuscript describes methods appropriate for the parallel synthesis of libraries based on the tricyclic thioxanthen-9-one-10,10-dioxide scaffold. The novel compounds were synthesized from previously reported 3-chlorothioxanthen-9-one-10,10-dioxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6bc0d7d6b7508a2d61b12c4e783a055
https://doi.org/10.1002/chin.200806125
https://doi.org/10.1002/chin.200806125
Autor:
G. L. Lokesh, Amarnath Natarajan, Sam Michael, Christopher P. Austin, Carleen Klumpp, Adam Yasgar, Ajit Jadhav, Anton Simeonov, James Inglese
Finding specific small-molecule inhibitors of protein-protein interactions remains a significant challenge. Recently, attention has grown toward “hot-spot” interactions where binding is dominated by a limited number of amino acid contacts, theore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3925897a1aa32bf8f82904c516f1b309
https://europepmc.org/articles/PMC3389998/
https://europepmc.org/articles/PMC3389998/
Autor:
Pedro M. J. Lory, Amarnath Natarajan, G. L. Lokesh, Estrella-Jimenez Maria, Scott R. Gilbertson, Matthew J. Shashack
This manuscript describes methods appropriate for the parallel synthesis of libraries based on the tricyclic thioxanthen-9-one-10,10-dioxide scaffold. The novel compounds were synthesized from previously reported 3-chlorothioxanthen-9-one-10,10-dioxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc49a8246f33ff258738e2178d86834d
https://europepmc.org/articles/PMC2040121/
https://europepmc.org/articles/PMC2040121/
Publikováno v:
ChemInform. 37
A mild and rapid protocol for cleavage of phosphate, phosphonate and phosphoramide esters. The scope and limitations of this microwave-assisted reaction is explored here.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee14ecabd0a55dadd0249c032977d481
https://doi.org/10.1002/chin.200650195
https://doi.org/10.1002/chin.200650195
Publikováno v:
Journal of the American Chemical Society. 129:10658-10659
Protein−protein interactions mediated by the carboxy terminus domains of breast cancer gene 1 (BRCT) play a critical role in the regulation of cell cycle checkpoints in response to DNA damage. DNA damage-induced checkpoint regulation bestows radiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5090698af37e24ca0055fa355f86ac33
https://doi.org/10.1021/ja0739178
https://doi.org/10.1021/ja0739178