Zobrazeno 1 - 10
of 80
pro vyhledávání: '"G. Krennrich"'
Autor:
Volker Strauss, B. van Ravenzwaay, C. Behr, Ivonne M.C.M. Rietjens, H. Kamp, T. Walk, Erik Peter, W. Mellert, G. Krennrich, E. Fabian
Publikováno v:
Archives of Toxicology 91 (2017) 10
Archives of Toxicology, 91(10), 3439-3454
Archives of Toxicology, 91(10), 3439-3454
The intestinal microbiota contributes to the metabolism of its host. Adequate identification of the microbiota’s impact on the host plasma metabolites is lacking. As antibiotics have a profound effect on the microbial composition and hence on the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46807d79e1aa8622af21e7bbb32f8d8c
https://doi.org/10.1007/s00204-017-1949-2
https://doi.org/10.1007/s00204-017-1949-2
Autor:
Michael Manfred Herold, H. Kamp, R. Looser, Natalie Bordag, A. Prokudin, W. Mellert, M. Spitzer, V. Strauss, Erik Peter, Lan Ma-Hock, G. Montoya, Rene Zbranek, B. van Ravenzwaay, E. Fabian, G. Krennrich, T. Walk
Publikováno v:
Toxicology Letters. 255:11-23
The MetaMap®-Tox database contains plasma-metabolome and toxicity data of rats obtained from oral administration of 550 reference compounds following a standardized adapted OECD 407 protocol. Here, metabolic profiles for aniline (A), chloroform (CL)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bcf9709de7c079a6783e0e29cf67c05
https://doi.org/10.1016/j.toxlet.2016.05.003
https://doi.org/10.1016/j.toxlet.2016.05.003
Autor:
V. Strauss, H. Kamp, E. Fabian, G. Krennrich, B. van Ravenzwaay, W. Mellert, T. Walk, Erik Peter, Michael Manfred Herold, R. Looser, G. Montoya
Publikováno v:
Toxicology Letters. 227:20-28
The identification of the no observed adverse effect level (NOAEL) is the key regulatory outcome of toxicity studies. With the introduction of “omics” technologies into toxicological research, the question arises as to how sensitive these technol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c156f8ab275cdf36956836ca0ac6d6e7
https://doi.org/10.1016/j.toxlet.2014.03.004
https://doi.org/10.1016/j.toxlet.2014.03.004
Autor:
B. van Ravenzwaay, T. Walk, H. Kamp, V. Strauss, R. Looser, W. Mellert, G. Krennrich, Michael Manfred Herold, E. Leibold, E. Fabian, J. Wiemer, A. Prokoudine
Publikováno v:
Toxicology Letters. 215:143-149
BASF has developed a rat plasma metabolomics database (MetaMap®Tox) containing the metabolome of more than 500 chemicals, agrochemicals and drugs, for which the toxicity is well known, derived from 28-day repeated dose toxicity studies in rats. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ee6fbdfe3250ffb1f9566b2e4e0293
https://doi.org/10.1016/j.toxlet.2012.09.015
https://doi.org/10.1016/j.toxlet.2012.09.015
Autor:
Hennicke Kamp, Eric Fabian, Michael Manfred Herold, Doerthe Ahlbory‐Dieker, Bennard van Ravenzwaay, Edgar Leibold, G. Krennrich, Werner Mellert, Alexandre Prokoudine, Volker Strauss, Ralf Looser, Jan C. Wiemer, Tilmann B. Walk
Publikováno v:
Modern Methods in Crop Protection Research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b04169289b2a6fadf7eb26f347f8b6a
https://doi.org/10.1002/9783527655908.ch13
https://doi.org/10.1002/9783527655908.ch13
Autor:
A. Prokoudine, Michael Manfred Herold, V. Strauss, H. Kamp, W. Mellert, Sibylle Groeters, E. Fabian, G. Krennrich, J. Wiemer, T. Walk, B. van Ravenzwaay, W. Mattes, P. Ruiz-Noppinger, R. Looser
Publikováno v:
Bioanalysis. 4:2291-2301
BASF and Metanomics have built-up the database MetaMap®-Tox containing rat plasma metabolome data for more than 500 reference compounds. Phenytoin was administered to five Wistar rats of both sexes at dietary dose levels of 600 and 2400 ppm over 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0632ec2a8d7d467af21a09d7ab37142b
https://doi.org/10.4155/bio.12.214
https://doi.org/10.4155/bio.12.214
Autor:
Michael Manfred Herold, M.D. Kapp, W. Mellert, H. Kamp, T. Walk, B. van Ravenzwaay, G. Krennrich, E. Fabian, J. Wiemer, V. Strauss, A. Prokoudine, R. Looser
Publikováno v:
Toxicology Letters. 207:173-181
Metabolite profiling (metabolomics) elucidates changes in biochemical pathways under various conditions, e.g., different nutrition scenarios or compound administration. BASF and metanomics have obtained plasma metabolic profiles of approximately 500
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd049633e0493ad4f1f5d80076ceb588
https://doi.org/10.1016/j.toxlet.2011.08.013
https://doi.org/10.1016/j.toxlet.2011.08.013
Autor:
Bennard van Ravenzwaay, Susanne N. Kolle, Stephanie Melching-Kollmuss, Robert Landsiedel, G. Krennrich
Publikováno v:
Regulatory Toxicology and Pharmacology. 60:373-380
Humans are exposed to a combination of various substances such as cosmetic ingredients, drugs, biocides, pesticides and natural-occurring substances in food. The combined toxicological effects of two or more substances can simply be additive on the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0010d1ba2aa513cc494201ff73856e24
https://doi.org/10.1016/j.yrtph.2011.05.005
https://doi.org/10.1016/j.yrtph.2011.05.005
Autor:
W. Mellert, G. Montoya, R. Looser, H. Kamp, Erik Peter, E. Fabian, B. van Ravenzwaay, V. Strauss, T. Walk, G. Krennrich, M. Herold
Publikováno v:
Toxicology letters. 225(2)
For identification of toxicological modes of action (MoAs) a database (MetaMap(®)Tox) was established containing plasma metabolome consisting of approximately 300 endogenous metabolites. Each five male and female Wistar rats per groups were treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e616faef1d9309e49f7503e0dd8b134
https://pubmed.ncbi.nlm.nih.gov/24370789
https://pubmed.ncbi.nlm.nih.gov/24370789
Autor:
P. Ruiz-Noppinger, K. Omura, S. Nadanaciva, A. Prokoudine, V. Strauss, B. van Ravenzwaay, S. P. Piccoli, Ina Schuppe-Koistinen, E. Fabian, E. D. Bush, H. Naraoka, Michael Manfred Herold, R. Looser, G. Krennrich, W. Mellert, T. Walk, W. Mattes, N. Moeller, H. G. Kamp
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2013 (2013)
BioMed Research International, Vol 2013 (2013)
Addressing safety concerns such as drug-induced kidney injury (DIKI) early in the drug pharmaceutical development process ensures both patient safety and efficient clinical development. We describe a unique adjunct to standard safety assessment where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0706b43f0ad774536b080748064df3ab
http://europepmc.org/articles/PMC3673329
http://europepmc.org/articles/PMC3673329