Zobrazeno 1 - 10
of 79
pro vyhledávání: '"G. Koev"'
Autor:
Emily O. Dumas, Kent D. Stewart, Michael D. Tufano, Jill Beyer, Neeta S. Panchal, Dachun Liu, Warren M. Kati, Lisa E. Hernandez, Todd W. Rockway, John K. Pratt, John T. Randolph, Clarence J. Maring, David W A Beno, G. Koev, Donner Pamela L, Yaya Liu, Motter Christopher E, Kenton L. Longenecker, Lynn Colletti, Rolf Wagner, Rubina Mondal, A. Chris Krueger, Hock B. Lim, Akhteruzzaman Molla
Publikováno v:
Journal of Medicinal Chemistry. 61:1153-1163
ABT-072 is a non-nucleoside HCV NS5B polymerase inhibitor that was discovered as part of a program to identify new direct-acting antivirals (DAAs) for the treatment of HCV infection. This compound was identified during a medicinal chemistry effort to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf57ddf93589bc577ed9ee07cab1807
https://doi.org/10.1021/acs.jmedchem.7b01630
https://doi.org/10.1021/acs.jmedchem.7b01630
Autor:
Akhteruzzaman Molla, Michelle Irvin, Thomas Reisch, Jill Beyer, Rolf Wagner, G. Koev, Rubina Mondal, Clarence J. Maring, Christine Collins, Preethi Krishnan, Warren M. Kati, Yaya Liu
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:1505-1511
Dasabuvir (ABT-333) is a nonnucleoside inhibitor of the RNA-dependent RNA polymerase encoded by the hepatitis C virus (HCV) NS5B gene. Dasabuvir inhibited recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates, with 50% in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8213e6535462b2d81f5015418846ef
https://doi.org/10.1128/aac.04619-14
https://doi.org/10.1128/aac.04619-14
Publikováno v:
Folia Medica, Vol 56, Iss 3, Pp 194-198 (2014)
ВВЕДЕНИЕ: YKL-40 представляет собой гликопротеин, который считается потенциальным маркером при патологических процессах. Высокие уровни Y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790dc2f2821ebabfab6f3d1e91c3789b
http://www.degruyter.com/view/j/folmed.2014.56.issue-3/folmed-2014-0028/folmed-2014-0028.xml?format=INT
http://www.degruyter.com/view/j/folmed.2014.56.issue-3/folmed-2014-0028/folmed-2014-0028.xml?format=INT
Autor:
Kenton L. Longenecker, G. Koev, A. Chris Krueger, Jill Beyer, Dachun Liu, John T. Randolph, Kent D. Stewart, Rolf Wagner, Warren M. Kati, Donner Pamela L, David W A Beno, Hutchinson Douglas K, Rubina Mondal, Yaya Liu, Todd W. Rockway, Hock B. Lim, Akhteruzzaman Molla, Clarence J. Maring, Charles A. Flentge, Christopher E. Motter, David A. Degoey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3487-3490
The synthesis and structure–activity relationships of a novel aryl uracil series which contains a fused 5,6-bicyclic ring unit for HCV NS5B inhibition is described. Several analogs display replicon cell culture potencies in the low nanomolar range
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f742a15f796c0f4b5fec021cc5a862f
https://doi.org/10.1016/j.bmcl.2013.04.057
https://doi.org/10.1016/j.bmcl.2013.04.057
Autor:
M H, Kazakova, D N, Staneva, I G, Koev, D G, Staikov, N, Mateva, P T, Timonov, G A, Miloshev, V S, Sarafian
Publikováno v:
Folia biologica. 60(6)
Malignant gliomas are the most common type of primary malignant brain tumours, characterized by extreme proliferation and aggressive invasion. There is evidence for over-expression of the YKL40 gene in high-grade gliomas. The high serum levels of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2571b0399814fe43505d71f6e9e55c68
https://pubmed.ncbi.nlm.nih.gov/25629266
https://pubmed.ncbi.nlm.nih.gov/25629266
Autor:
Warren M. Kati, Thomas Reisch, Laura A. Williams, Tami Pilot-Matias, David A. Degoey, Wangang Xie, Carolyn M. Setze, Christine Collins, Neeta Mistry, Preethi Krishnan, G. Koev, Akhteruzzaman Molla, Jill Beyer, Campbell Andrew L
Ombitasvir (ABT-267) is a hepatitis C virus (HCV) NS5A inhibitor with picomolar potency, pan-genotypic activity, and 50% effective concentrations (EC 50 s) of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a. Ombitasvir ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edaf9b0d5f55b0efe30fb426c40131f
https://europepmc.org/articles/PMC4335823/
https://europepmc.org/articles/PMC4335823/
Autor:
Ilyan G. Koev, Christo B. Zhelyazkov, Stefan D. Raykov, Atanas Davarski, Ivo Kehayov, Borislav M. Kalnev, Borislav Kitov
Publikováno v:
Folia medica. 55(3-4)
OBJECTIVE: To present the results from the clinical presentation, the imaging diagnostics, surgery and postoperative status of 17 patients with cervical spine metastases, to analyse all data and make the respective conclusions and compare them with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6cf705987eec95f45dfbde293558b2
https://pubmed.ncbi.nlm.nih.gov/24712281
https://pubmed.ncbi.nlm.nih.gov/24712281
Autor:
Laura A. Williams, Tami Pilot-Matias, G. Koev, Daniel D. Caspi, Preethi Krishnan, Christine Collins, Mark A. Matulenko, Warren M. Kati, Nelson Lissa T, Ryan G. Keddy, Michael D. Tufano, A. Chris Krueger, Yi Gao, David A. Degoey, Campbell Andrew L, John K. Pratt, Akhter Molla, Thomas Reisch, David W A Beno, Neeta Mistry, John T. Randolph, Sachin V. Patel, Charles W. Hutchins, Donner Pamela L, Motter Christopher E, Rolf Wagner, Dachun Liu, Clarence J. Maring, Rubina Mondal, Emily O. Dumas
Publikováno v:
Journal of medicinal chemistry. 57(5)
We describe here N-phenylpyrrolidine-based inhibitors of HCV NS5A with excellent potency, metabolic stability, and pharmacokinetics. Compounds with 2S,5S stereochemistry at the pyrrolidine ring provided improved genotype 1 (GT1) potency compared to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c8534b20bcdc5d6b39425a9a25b34b
https://pubmed.ncbi.nlm.nih.gov/24400777
https://pubmed.ncbi.nlm.nih.gov/24400777
Autor:
G. Koev, B. Bernstein, Rajeev M. Menon, S. Siggelkow, Daniel E. Cohen, Kris V. Kowdley, Thomas Podsadecki, Lois Larsen, Fred Poordad, Eric Lawitz, Rakesh Tripathi, Tami Pilot-Matias
Publikováno v:
Journal of hepatology. 59(1)
ABT-450 (combined with low-dose ritonavir, ABT-450/r) is a potent HCV NS3 protease inhibitor, and ABT-072 is a non-nucleoside NS5B polymerase inhibitor. The goal of this study was to evaluate the safety, tolerability, and efficacy of the peginterfero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ed90f7f2362367dff9ccee17b50157
https://pubmed.ncbi.nlm.nih.gov/23439262
https://pubmed.ncbi.nlm.nih.gov/23439262
Publikováno v:
Phytopathology. 88(10)
Koev, G., Mohan, B. R., Dinesh-Kumar, S. P., Torbert, K. A., Somers, D. A., and Miller, W. A. 1998. Extreme reduction of disease in oats transformed with the 5′ half of the barley yellow dwarf virus-PAV genome. Phytopathology 88:1013-1019. Barley y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b400b50a9f13e9c2de3e3b0f7c3f0b1
https://pubmed.ncbi.nlm.nih.gov/18944812
https://pubmed.ncbi.nlm.nih.gov/18944812