Zobrazeno 1 - 10
of 201
pro vyhledávání: '"G. Klupp"'
Autor:
Melina Vallbracht, Marina Schnell, Annemarie Seyfarth, Walter Fuchs, Richard Küchler, Thomas C. Mettenleiter, Barbara G. Klupp
Publikováno v:
Viruses, Vol 16, Iss 1, p 26 (2023)
Herpesvirus entry requires the coordinated action of at least four viral glycoproteins. Virus-specific binding to a cellular receptor triggers a membrane fusion cascade involving the conserved gH/gL complex and gB. Although gB is the genuine herpesvi
Externí odkaz:
https://doaj.org/article/db941c5b57c64ae6b5746da12985bf49
Publikováno v:
Viruses, Vol 15, Iss 6, p 1283 (2023)
African swine fever is a viral disease of swine caused by the African swine fever virus (ASFV). Currently, ASFV is spreading over the Eurasian continent and threatening global pig husbandry. One viral strategy to undermine an efficient host cell resp
Externí odkaz:
https://doaj.org/article/087481cfb3dd42dda7d64319767ec45e
Autor:
Jonas L Delva, Cliff Van Waesberghe, Barbara G Klupp, Thomas C Mettenleiter, Herman W Favoreel
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1010117 (2021)
Plasmacytoid dendritic cells (pDC) are important innate immune cells during the onset of viral infections as they are specialized in the production of massive amounts of antiviral type I interferon (IFN). Alphaherpesviruses such as herpes simplex vir
Externí odkaz:
https://doaj.org/article/0d1ceb4dee1a43358afdc2d1d5a78d7c
Autor:
Melina Vallbracht, Henriette Lötzsch, Barbara G. Klupp, Walter Fuchs, Benjamin Vollmer, Kay Grünewald, Marija Backovic, Felix A. Rey, Thomas C. Mettenleiter
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
The class III fusion protein glycoprotein B (gB) drives membrane fusion during entry and spread of herpesviruses. To mediate fusion, gB requires activation by the conserved gH/gL complex by a poorly defined mechanism.
Externí odkaz:
https://doaj.org/article/43a561b2c81d4a709bcf0876adf1eaf4
Autor:
Julia Sehl, Julia E Hölper, Barbara G Klupp, Christina Baumbach, Jens P Teifke, Thomas C Mettenleiter
Publikováno v:
PLoS Pathogens, Vol 16, Iss 3, p e1008445 (2020)
Herpesviral encephalitis caused by Herpes Simplex Virus 1 (HSV-1) is one of the most devastating diseases in humans. Patients present with fever, mental status changes or seizures and when untreated, sequelae can be fatal. Herpes Simplex Encephalitis
Externí odkaz:
https://doaj.org/article/8ccc7303e5cc4f27bee87caa1a8e041b
Autor:
Julia E. Hölper, Finn Grey, John Kenneth Baillie, Tim Regan, Nicholas J. Parkinson, Dirk Höper, Thiprampai Thamamongood, Martin Schwemmle, Katrin Pannhorst, Lisa Wendt, Thomas C. Mettenleiter, Barbara G. Klupp
Publikováno v:
Viruses, Vol 13, Iss 8, p 1574 (2021)
Herpesviruses are large DNA viruses, which encode up to 300 different proteins including enzymes enabling efficient replication. Nevertheless, they depend on a multitude of host cell proteins for successful propagation. To uncover cellular host facto
Externí odkaz:
https://doaj.org/article/a3f7112d71f844f6b3eef668d19d5721
Publikováno v:
Annual Review of Virology. 10
Nuclear egress of herpesvirus capsids across the intact nuclear envelope is an exceptional vesicle-mediated nucleocytoplasmic translocation resulting in the delivery of mature herpesvirus capsids into the cytosol. Budding of the (nucleo)capsid at and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89bf52c91eb53e94bf1ae01985061cb0
https://doi.org/10.1146/annurev-virology-111821-105518
https://doi.org/10.1146/annurev-virology-111821-105518
Autor:
Anna D. Dorsch, Julia E. Hölper, Kati Franzke, Luca M. Zaeck, Thomas C. Mettenleiter, Barbara G. Klupp
Publikováno v:
Viruses, Vol 13, Iss 6, p 1117 (2021)
The molecular mechanism affecting translocation of newly synthesized herpesvirus nucleocapsids from the nucleus into the cytoplasm is still not fully understood. The viral nuclear egress complex (NEC) mediates budding at and scission from the inner n
Externí odkaz:
https://doaj.org/article/1a502f7b4495458fbe723b41c5da4585
Autor:
Barbara G. Klupp
Publikováno v:
Pathogens, Vol 10, Iss 6, p 719 (2021)
Suid alphaherpesvirus 1 (SuHV-1), better known as Pseudorabies virus (PrV), an alphaherpesvirus of swine, is the causative agent of Aujeszky’s Disease [...]
Externí odkaz:
https://doaj.org/article/17ac087dee3d4bd2aa1505ec186bf5e5
Publikováno v:
Pathogens, Vol 10, Iss 1, p 61 (2021)
Envelope glycoprotein (g)B is conserved throughout the Herpesviridae and mediates fusion of the viral envelope with cellular membranes for infectious entry and spread. Like all viral envelope fusion proteins, gB is modified by asparagine (N)-linked g
Externí odkaz:
https://doaj.org/article/8040c6956b7c41c1aa4d8d51e98df6cc