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The effect of the length and flexibility of the side chain of basic amino acids on the binding of antimicrobial peptides to zwitterionic and anionic membrane model systems

Autor: Brittany C. Williams, David G. Klapper, Amanda L. Russell, Rickey P. Hicks, Antoine H. Srouji, Anne M. Spuches

Publikováno v: Bioorganic & Medicinal Chemistry. 20:1723-1739

The intent of this investigation was to determine the effect of varying the side chain length of the basic amino acids residues on the binding of a series of antimicrobial peptides (AMPs) to zwitterionic and anionic LUVs, SUVs and micelles. These AMP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5122c6f9ff6494c11584ab11a103e054
https://doi.org/10.1016/j.bmc.2012.01.015

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Determining the effect of the incorporation of unnatural amino acids into antimicrobial peptides on the interactions with zwitterionic and anionic membrane model systems

Autor: Divakaramenon Venugopal, Anthony Kennedy, Jayendra B. Bhonsle, Antoine H. Srouji, David G. Klapper, Rickey P. Hicks, Amanda L. Russell, William S. Gibson, Anne M. Spuches

Publikováno v: Chemistry and Physics of Lipids. 164:740-758

Circular Dichroism (CD), isothermal calorimetry (ITC) and calcein fluorescence leakage experiments were conducted to provide insight into the mechanisms of binding of a series of antimicrobial peptides containing unnatural amino acids (Ac-XF-Tic-Oic-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13895a17cce247baa825eb031d17fbc4
https://doi.org/10.1016/j.chemphyslip.2011.09.003

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Arginine catabolic mobile element encoded speG abrogates the unique hypersensitivity of Staphylococcus aureus to exogenous polyamines

Autor: Jeffrey S. Spontak, Anthony R. Richardson, David G. Klapper, Gauri S. Joshi

Publikováno v: Molecular Microbiology. 82:9-20

Polyamines, including spermine (Spm) and spermidine (Spd), are aliphatic cations that are reportedly synthesized by all living organisms. They exert pleiotropic effects on cells and are required for efficient nucleic acid and protein synthesis. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ced19795d40da9a1631d41d481a50c2
https://doi.org/10.1111/j.1365-2958.2011.07809.x

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Novel antimicrobial peptides that exhibit activity against select agents and other drug resistant bacteria

Autor: Rickey P. Hicks, Brittany C. Williams, Allen J. Mueller, Antoine H. Srouji, Jayendra B. Bhonsle, David G. Klapper, Divakaramenon Venugopal, Richard Borschel, Amanda L. Russell

Publikováno v: Bioorganic & Medicinal Chemistry. 18:5137-5147

One of the greatest challenges facing modern medicine is the evolution of drug resistant strains of bacteria. In addition to traditional methods of exposure to traditional bacterial organisms there is a growing concerned of the use of bacteria as bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20df4bd9a731c3ecfaabb85a0c3bf7cf
https://doi.org/10.1016/j.bmc.2010.05.065

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