Zobrazeno 1 - 10 of 44 pro vyhledávání: '"G. K. Scott"'
1
Growth-Related Proteinases in Cultured Human Tumour Cells
Autor: Cynthia A. Tse, G. K. Scott
Publikováno v: Biological Chemistry Hoppe-Seyler. 373:605-610
The proliferation of normal cells, and of early-passage cells from tumours, is inhibited as a consequence of inhibition of a cell-surface proteinase activity. In contrast, established tumour cell lines are usually resistant to these effects. It has p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fe2c981b81ce33789e4ddfefd9e56d
https://doi.org/10.1515/bchm3.1992.373.2.605
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3
Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumors with acquired tamoxifen resistance
Autor: S R, Johnston, B, Lu, G K, Scott, P J, Kushner, I E, Smith, M, Dowsett, C C, Benz
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(2)
Human breast tumors that are initially responsive to tamoxifen (TAM) eventually relapse during treatment. Estrogen receptor (ER) expression and function are often preserved in these tumors, and clinical evidence suggests that this relapse may be rela
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3c8455aed3ad49739156139a6839ae1
https://pubmed.ncbi.nlm.nih.gov/10037172
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4
Comparison of estrogen receptor DNA binding in untreated and acquired antiestrogen-resistant human breast tumors
Autor: S R, Johnston, B, Lu, M, Dowsett, X, Liang, M, Kaufmann, G K, Scott, C K, Osborne, C C, Benz
Publikováno v: Cancer research. 57(17)
Preliminary studies have suggested that measuring the ability of immunoreactive 67-kDa estrogen receptor (ER) to bind DNA and form in vitro complexes with its cognate estrogen response element (ERE) might serve to identify breast tumors most likely t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ab7be9c37396831a0cc24ec67e72d14f
https://pubmed.ncbi.nlm.nih.gov/9288779
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5
Isolation, characterisation and cell growth-regulatory properties of kumara (sweet potato) trypsin inhibitors
Autor: G K, Scott, C W, Symes
Publikováno v: Biochemistry and molecular biology international. 38(2)
Locally grown kumara (sweet potato; Ipomea batatis) was used as the starting point for the purification of a proteinase inhibitor. The purified inhibitor was highly specific for trypsin, and much less effective as an inhibitor of chymotrypsin. Two 22
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e30f1ba37669b71fe2c4d97aa31641e
https://pubmed.ncbi.nlm.nih.gov/8850529
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7
Purification, characterization and developmental expression of indole-3-ethanol oxidase from seeds of Phaseolus vulgaris
Autor: J S, Zhu, G K, Scott
Publikováno v: Biochemistry and molecular biology international. 35(2)
Purification of indole-3-ethanol (IEt) oxidase was carried out from extracts of the seeds of two bean cultivars. The IEt oxidase from the Labrador cultivar was purified more than 1000-fold and had a molecular weight of about 56 kD. The enzyme reactio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0824b7e1a9c389c0d17e6b8a587cfec3
https://pubmed.ncbi.nlm.nih.gov/7663398
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8
Binding of an ETS-related protein within the DNase I hypersensitive site of the HER2/neu promoter in human breast cancer cells
Autor: G K, Scott, J C, Daniel, X, Xiong, R A, Maki, D, Kabat, C C, Benz
Publikováno v: The Journal of biological chemistry. 269(31)
Promoter elements accounting for HER2 (c-erbB-2/neu) overexpression were searched for in several human breast cancer cell lines (MDA-453, BT-474, ZR-75-1, MCF-7) known to express constitutively a 30-fold range in HER2 transcripts per gene copy. HER2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96092c0a25767fdd29205e69baa86438
https://pubmed.ncbi.nlm.nih.gov/7914192
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9
In vivo generation of highly abundant sequence-specific oligonucleotides for antisense and triplex gene regulation
Autor: Sarah B. Noonberg, G K Scott, C C Benz, Marvin R. Garovoy, C. A. Hunt
Antisense and triplex oligonucleotides continue to demonstrate potential as mediators of gene-specific repression of protein synthesis. However, inefficient and heterogeneous cellular uptake, intracellular sequestration, and rapid intracellular and e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5feaf935fb8fc61b9c556a8a43ae59
https://europepmc.org/articles/PMC308254/
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10
Changes in sensitivity of human tumour cells to growth inhibition by proteinase inhibitors
Autor: Cynthia A. Tse, G. K. Scott
Publikováno v: Cell biology international. 18(2)
Inhibition of a cell-surface proteinase can inhibit the growth of many normal human cell types in culture. Some tumour cells are also sensitive to proteinase inhibitors, but others are resistant, and continue to grow in the presence of these inhibito
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd6df4180e8eff6359239aeda6720d3
https://pubmed.ncbi.nlm.nih.gov/8019486
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