NNC6019–0001, a humanized monoclonal antibody, in patients with transthyretin amyloid cardiomyopathy (ATTR-CM): rationale and study design of a phase 2, randomized, placebo-controlled trial

Autor: M Fontana, K Buchholtz, M D M Engelmann, M Grogan, G K Hovingh, A V Kristen, P Poulsen, S J Shah, M S Maurer

Publikováno v: European Heart Journal. 43

Introduction Transthyretin amyloid cardiomyopathy (ATTR-CM) is a chronic condition associated with progressive heart failure, resulting from extracellular deposition of misfolded transthyretin (TTR) protein as amyloid fibrils in the myocardium. Curre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::159fa4765d5def53fd337b15e68ca433
https://doi.org/10.1093/eurheartj/ehac544.1767

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Autor: Tove Fall, Anubha Mahajan, Dmitry Shungin, B. Balkau, Gerjan Navis, A. Metspalu, Anneli Pouta, Andrew A. Hicks, Ilja M. Nolte, Ian Ford, Aroon D. Hingorani, Stefan R Bornstein, Anuj Goel, Rona J. Strawbridge, Niek Verweij, Sarah H. Wild, Patricia B. Munroe, T.B. Harris, Jaana Lindström, Johnson Pcd., Nita G. Forouhi, Pierre Meneton, Patricia A. Peyser, Sarin A-P., Andrea Ganna, Timothy M. Frayling, Patrik K. E. Magnusson, Joanne M. Meyer, Yongmei Liu, Jeanette M. Stafford, Christian Herder, L Zudina, Maria G. Stathopoulou, May E. Montasser, Nicholas D. Hastie, Inês Barroso, Schwarz Peh., James B. Meigs, Perttu Salo, George Davey Smith, Gonneke Willemsen, Christopher J. Groves, Erik P A Van Iperen, M. A. Province, Veikko Salomaa, Naveed Sattar, Serena Sanna, Maria Dimitriou, Joop Jukema, Ulrika Krus, Albert V. Smith, Markku Laakso, James F. Wilson, George Nicholson, Loic Yengo, Tatijana Zemunik, Per Eriksson, Harold Snieder, Peter P. Pramstaller, Claudia Langenberg, R. Rauramaa, Alan R. Shuldiner, Pau Navarro, Veronique Vitart, Ross M. Fraser, Aaron Isaacs, C. Lecoeur, Jesper R. Gådin, Jackie F. Price, Letizia Marullo, L.F. Bielak, Sirkka Keinänen-Kiukaanniemi, Amélie Bonnefond, Michael Stumvoll, Alessia Faggian, Anke Tönjes, Tomohiro Tanaka, Wieland Kiess, Harry Campbell, Josée Dupuis, David Altshuler, João Fadista, Winfried März, G K Hovingh, Thomas Illig, Toby Johnson, H Grallert, Kari Stefansson, Reedik Mägi, Palmer Cna., de Geus Ejcn., Martina Müller-Nurasyid, Karen Kapur, Philippe Froguel, Dorret I. Boomsma, Anders Franco-Cereceda, Marcus E. Kleber, Boehnke M, Olga D. Carlson, Ozren Polasek, Andrew P. Morris, Alex S. F. Doney, Najaf Amin, Sara M. Willems, Vilmundur Gudnason, Jose C. Florez, Jeffery R. O'Connell, Nancy L. Pedersen, T. Saaristo, Wolffenbuttel Bhr., M. I. J. Uusitupa, Longda Jiang, Iva Miljkovic, James S. Pankow, Caroline Hayward, Hugh Watkins, Vasiliki Lagou, Johanna Kuusisto, Jaakko Tuomilehto, Alan F. Wright, Josephine M. Egan, Perry Jrb., C M van Duijn, Valeriya Lyssenko, Leif Groop, Stefania Bandinelli, Nigel W. Rayner, Tõnu Esko, Stela McLachlan, Momoko Horikoshi, Eric Boerwinkle, Rick Jansen, Richard N. Bergman, Gudmar Thorleifsson, Lyle J. Palmer, Vilmantas Giedraitis, Peter Kovacs, Nicholas J. Wareham, Luigi Ferrucci, N J Timpson, D Rybin, Anne U. Jackson, Tiinamaija Tuomi, Gonçalo R. Abecasis, Harst Pvd., Meena Kumari, Albert Hofman, Chiara Scapoli, Evelin Mihailov, Josine L. Min, Anders Hamsten, Hottenga J-J., Loos Rjf., Lars Lind, Ulf de Faire, Jaakko Kaprio, Guo Li, Beate St Pourcain, C Gieger, Amanda J. Bennett, Anna Ulrich, Nabila Bouatia-Naji, Satu Männistö, Antigone S. Dimas, Jarvelin M-R., Günther Silbernagel, F Karpe, A. Körner, David S. Siscovick, M Blüher, Rebecca J. Webster, Erik Ingelsson, Susan Campbell, Mika Kivimäki, Laura J. Rasmussen-Torvik, Heikki A. Koistinen, Sophie Visvikis-Siest, Bernhard O. Boehm, Inga Prokopenko, Ping An, Emmanouil T. Dermitzakis, Cecilia M. Lindgren, Kardia Slr., Richa Saxena, Igor Rudan, Richard M. Watanabe, Jian'an Luan, Marika Kaakinen, Shin S-Y., George Dedoussis, Panagiotis Deloukas, Mark I. McCarthy, Barbara Thorand, B.W.J.H. Penninx, Peter Vollenweider, Paul W. Franks, Leena Kinnunen, Markus Perola, Yvonne Boettcher, Timo A. Lakka, Nicole Soranzo, Stavroula Kanoni, Bakker Sjl., Winkelmann Br

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.24. ⟨10.1038/s41467-020-19366-9⟩
Nature communications, 12(1):24. Nature Publishing Group
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9, https://doi.org/10.1038/s41467-020-19366-9
Nature Communications, 2021, 12 (1), pp.24. ⟨10.1038/s41467-020-19366-9⟩
Nature Communications, 12(1):24, 1-18. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, 12(1):24. Nature Publishing Group
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9
Nature Communications, 12(1):24. Nature Publishing Group UK
Lagou, V, Mägi, R, Hottenga, J J, Jansen, R, Min, J L, Willemsen, G, De Geus, E J C N, Penninx, B W, Boomsma, D I, Barroso, I, Morris, A P, Prokopenko, I & MAGIC Collaboration 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24, pp. 1-18 . https://doi.org/10.1038/s41467-020-19366-9
Min, J L, St Pourcain, M U B, Timpson, N J, Davey Smith, G, Prokopenko, I & et al. 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, 24 . https://doi.org/10.1038/s41467-020-19366-9
2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9, https://doi.org/10.1038/s41467-021-21276-3
Nature communications, vol. 12, no. 1, pp. 24
Nature Communications, 12(1). NATURE RESEARCH

Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5783e9d2579548e3deb52d1bbdf19db
https://hal.univ-lorraine.fr/hal-03105716

P5387LDL cholesterol, apolipoprotein B, lipoprotein(a), apolipoprotein CIII and triglyceride lowering by MGL-3196, a thyroid hormone beta selective agonist, in a 12 week study in HeFH patients

Autor: G K Hovingh, I. C. Klausen, John J.P. Kastelein, R Taub, Gisle Langslet, E Heggen

Publikováno v: European Heart Journal. 39

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f9c1d515f4b5e84dad0341e7b003401
https://doi.org/10.1093/eurheartj/ehy566.p5387

Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals

Autor: Barbara E.K. Klein, Molly A. Hall, Eric B. Larson, Gerard Tromp, G K Hovingh, Carrie B. Moore, Suthesh Sivapalaratnam, Erik P A Van Iperen, Marcus E. Kleber, Yvonne T. van der Schouw, Antoinette Amuzu, Jens Baumert, Mika Kivimäki, Ariel Brautbar, Alexander P. Reiner, Emily R. Holzinger, Philippa J. Talmud, Scott M. Dudek, Ronald Klein, Gail P. Jarvik, Caroline Dale, Leslie A. Lange, N. Charlotte Onland-Moret, Fotios Drenos, Rishika De, Shefali S. Verma, Daniel Seung Kim, Aroon D. Hingorani, Martin Farrall, Brendan J. Keating, Kari E. North, Tom R. Gaunt, Marylyn D. Ritchie, Vinicius Tragante, Helena Kuivaniemi, David Carrell, Iftikhar J. Kullo, Matthew B. Lanktree, Jason H. Moore, Laura J. Rasmussen-Torvik, James G. Wilson, David R. Crosslin, Nathan Pankratz, Winfried Mӓrz, Meena Kumari, Amber A. Burt, Diane Gilbert-Diamond, Karen J. Cruickshanks, Folkert W. Asselbergs, Clement E. Furlong, Helene Riess, Wolfgang Koenig

Publikováno v: BioData Min. 10:25 (2017)
BioData Mining, Vol 10, Iss 1, Pp 1-20 (2017)
BioData mining, 10. BioMed Central
BioData mining [E], 10(1). BioMed Central
BioData Mining

Background The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipoprotein chol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ca277cf2f00cd4e89e9ae84e2e63f1
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=51634

Extending the use of GWAS data by combining data from different genetic platforms

Autor: E. P. A. van Iperen, A. H. Zwinderman, G K Hovingh, Folkert W. Asselbergs

Publikováno v: PLoS ONE
PLoS ONE, 12(2):e0172082. Public Library of Science
PLoS ONE, Vol 12, Iss 2, p e0172082 (2017)
PLoS ONE [E], 12(2). Public Library of Science

BACKGROUND: In the past decade many Genome-wide Association Studies (GWAS) were performed that discovered new associations between single-nucleotide polymorphisms (SNPs) and various phenotypes. Imputation methods are widely used in GWAS. They facilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db30f16e171786e966c67c15890442d
https://pubmed.ncbi.nlm.nih.gov/28245255