Zobrazeno 1 - 10
of 30
pro vyhledávání: '"G. J. Tsongalis"'
Publikováno v:
EJIFCC
The discovery of miRNAs in the mid-90s has changed the dogma of gene expression regulation. Currently, miRNAs are the main theme of thousands of publications each year and their involvement in human diseases is everyday more deeply understood. With t
Publikováno v:
Bone marrow transplantation. 55(6)
Detectable in biopsies and body fluids, the measurement of a single or panels of microRNAs have been reported to be quite sensitive and specific for the prediction, diagnosis, and prognosis of many diseases. Interest in the use of microRNAs as biomar
Publikováno v:
Clinical genetics. 86(1)
Breast cancer is a complex disease characterized by many morphological, clinical and molecular features. For many years, this disease has been classified according to histopathologic criteria, known as the tumor, node and metastasis (TNM) staging sys
Publikováno v:
Archives of Pathology & Laboratory Medicine. 123:768-773
Background.—Parvovirus B19 infection is a cause of chronic anemia and red cell aplasia in patients with acquired immunodeficiency syndrome (AIDS) and in other immunocompromised hosts. Anemia in AIDS patients has a multifactorial etiology, with parv
Publikováno v:
Cell Biology and Toxicology. 11:251-261
Autocrine and paracrine interactions between cells are important homeostatic mediators in normal tissues. Alterations to growth factor signalling pathways are likely to play a role in multistep carcinogenesis. In this study normal human endometrial e
Publikováno v:
Connecticut medicine. 65(11)
Telomeres are the terminal portions of chromosomes and consist of the repeated nucleotide sequence TTAGGG. Chromosomes lose a small amount of telomeric deoxyribonucleic acid (DNA) after each cell replication. A hypothetical function of telomeric DNA
Publikováno v:
American clinical laboratory. 20(3)
The READIT system represents the newest contribution to point mutation detection technology. Specifically, the system involves hybridizing DNA or RNA probes using phosphorylation chemistry and luciferase as the detection method. The two primary featu
Autor:
R B, Rhodes, K, Lewis, J, Shultz, S, Huber, K V, Voelkerding, D G, Leonard, G J, Tsongalis, D D, Kephart
Publikováno v:
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology. 6(1)
A variety of methods exist for the detection of single-nucleotide polymorphisms (SNPs) present in amplified segments of genomic DNA. We show the application of a novel SNP scoring tool for analysis of the factor V Leiden mutation.We have developed a
Publikováno v:
Connecticut medicine. 64(5)
We report a case of a 35-year-old male with a history of recurrent thromboembolic events, who presented to the emergency room with right sided weakness and difficulty with speech. The patient's past medical history included two myocardial infarctions
Autor:
W B, Coleman, G J, Tsongalis
Publikováno v:
Anticancer research. 19(6A)
Neoplastic cells typically possess numerous genomic lesions, which may include sequence alterations (point mutations, small deletions, and insertions) and/or gross structural abnormalities in one or more chromosomes (large-scale deletions, rearrangem