Zobrazeno 1 - 10
of 51
pro vyhledávání: '"G. J. Roth"'
Autor:
G J Roth, Andreas Schnapp, Nveed Chaudhary, Antje Prasse, Joachim Müller-Quernheim, Frank Hilberg, John Edward Park, Gernot Zissel
Publikováno v:
European Respiratory Journal. 29:976-985
BIBF 1000 is a small molecule inhibitor targeting the receptor kinases of platelet-derived growth factor (PDGF), basic fibroblast growth factor and vascular endothelial growth factor, which have known roles in the pathogenesis of pulmonary fibrosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0319f4ec82e1c8c7032e2669bd71188
https://doi.org/10.1183/09031936.00152106
https://doi.org/10.1183/09031936.00152106
Autor:
S D, Russell, G J, Roth
Publikováno v:
Blood. 81:1787-1791
Pseudo (platelet-type)-von Willebrand disease is an autosomal dominant bleeding disorder caused by the hyperfunction of a receptor on the platelet surface. The abnormal receptor, glycoprotein Ib, displays increased affinity for its ligand, von Willeb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cab5a26f114138d0d272103efdafc83
https://doi.org/10.1182/blood.v81.7.1787.bloodjournal8171787
https://doi.org/10.1182/blood.v81.7.1787.bloodjournal8171787
Autor:
G. J. Roth, M. Yagi
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 4(9)
Summary. Background: During differentiation, megakaryocytes (MK), the bone marrow precursors of circulating blood platelets, undergo polyploidization, repeated rounds of DNA replication without cell division. Mature normal MK may contain a DNA conten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca28cd8045defc40b1c0ca5921e4cb9f
https://pubmed.ncbi.nlm.nih.gov/16805859
https://pubmed.ncbi.nlm.nih.gov/16805859
Autor:
B M, Trost, G J, Roth
Publikováno v:
Organic letters. 1(1)
[formula: see text] A synthesis of gamma-amino acids and their cyclic derivatives, 3-pyrrolinones, from alpha-amino acids employs a ruthenium-catalyzed Alder ene reaction as a key step in the sequence. Cyclopentadienylruthenium (1,4-cyclooctadiene) c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6189d6b73b23180d3a3d8b71edc98c8c
https://pubmed.ncbi.nlm.nih.gov/10822535
https://pubmed.ncbi.nlm.nih.gov/10822535
Publikováno v:
SAE Technical Paper Series.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dcf491b7d0291b056de01e837cdfad2
https://doi.org/10.4271/1999-01-3636
https://doi.org/10.4271/1999-01-3636
Autor:
D C, Calverley, G J, Roth
Publikováno v:
Hematology/oncology clinics of North America. 12(6)
Aspirin is the most widely employed antithrombotic agent in use today and has a proven role in the prevention and acute management of atherosclerosis-associated arterial thrombotic events. More recently developed antiplatelet agents have been found t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::453134e44b50851621e6e038d8f1b43a
https://pubmed.ncbi.nlm.nih.gov/9922934
https://pubmed.ncbi.nlm.nih.gov/9922934
Publikováno v:
Blood. 91(4)
The initiation of primary hemostasis is mediated by interaction of the platelet glycoprotein Ib (GPIb) surface receptor and its arterial subendothelial von Willebrand factor (vWF) ligand. The intracellular signaling immediately following GPIb recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22a6b46c576967abc896cf9688fbd072
https://pubmed.ncbi.nlm.nih.gov/9454760
https://pubmed.ncbi.nlm.nih.gov/9454760
Publikováno v:
Thrombosis and haemostasis. 76(5)
Bernard-Soulier syndrome is a rare congenital platelet disorder that affects a surface membrane adhesion receptor, glycoprotein (GP) Ib-V-IX. Both the genetic defects and the bleeding diatheses associated with the syndrome are heterogeneous due, in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e64e12a1d3934b4b6bd21a82748579c3
https://pubmed.ncbi.nlm.nih.gov/8950770
https://pubmed.ncbi.nlm.nih.gov/8950770
Autor:
G J, Roth
Publikováno v:
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. 319(9)
Bernard-Soulier syndrome involves a multicomponent adhesion receptor on the surface of human platelets. Patients with this disorder bleed excessively from the skin and mucous membranes; and in occasional cases, the bleeding is fatal. At a molecular l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb6dc05cb753634bd58a4f3353ed8b9e
https://pubmed.ncbi.nlm.nih.gov/8952885
https://pubmed.ncbi.nlm.nih.gov/8952885
Publikováno v:
Stem cells (Dayton, Ohio). 14
Platelet glycoproteins (GPs) Ib-V-IX form the surface receptor for von Willebrand factor, and this receptor-ligand interaction mediates the shear-dependent adhesion of platelets to damaged arterial vessel walls. The receptor is a multicomponent struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ff697f8ecb01755200ebebf1d75d8b85
https://pubmed.ncbi.nlm.nih.gov/11012220
https://pubmed.ncbi.nlm.nih.gov/11012220