Cross-lineage T cell receptor gene rearrangements occur in more than ninety percent of childhood precursor-B acute lymphoblastic leukemias: alternative PCR targets for detection of minimal residual disease

Autor: M. J. Pongers-Willemse, Annemarie J. M. Wijkhuijs, E. R. Van Wering, Karel Hählen, Auke Beishuizen, M. A. C. De Bruijn, J. J. M. Van Dongen, Tomasz Szczepański, G. J. M. Tibbe

Publikováno v: Leukemia. 13:196-205

A large series of 202 childhood precursor-B cell acute lymphoblastic leukemia (ALL) patients was analyzed by Southern blotting (SB) for cross-lineage rearrangements and/or deletions in the T cell receptor TCRB, TCRG and TCRD loci. In 93% (187/201) of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83770533f3f512834cbf019f1ad42f7d
https://doi.org/10.1038/sj.leu.2401277

CD4+cells proliferate after peanut-extract-specific and CD8+cells proliferate after polyclonal stimulation of PBMC of children with atopic dermatitis

Autor: Arnold P. Oranje, M.P. Laan, E. P. E. Bosmans, Herman J. Neijens, G. J. M. Tibbe, Huub F. J. Savelkoul

Publikováno v: Clinical & Experimental Allergy. 28:35-44

Background Few studies describe in vitro food-allergen induced proliferative responses and cytokine production of PBMC of children with atopic dermatitis. This is especially true for peanut-allergen. Objectives To analyse the specificity of the T cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18cd986bc02e2fdb1f66ba34dfbe10de
https://doi.org/10.1046/j.1365-2222.1998.00168.x

SUPPRESSION OF SKIN ALLOGRAFT REJECTION IN MICE BY ANTI-CD3 MONOCLONAL ANTIBODIES WITHOUT CYTOKINE-RELATED SIDE-EFFECTS1

Autor: Ann C. T. M. Vossen, A. Van Oudenaren, G. J. M. Tibbe, André C. Knulst, Huub F. J. Savelkoul, Robbert Benner, Miranda R. M. Baert

Publikováno v: Transplantation. 58:257-260

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::058439dd3f741dd18169ad2f5ec8082b
https://doi.org/10.1097/00007890-199407270-00022

Cytokine Detection and Modulation in Acute Graft vs. Host Disease in Mice

Autor: E. G. Breedland, A. C. Knulst, A. van Oudenaren, Huub F. J. Savelkoul, Robbert Benner, G. J. M. Tibbe, C. Bril-Bazuin

Publikováno v: Mediators of Inflammation, Vol 3, Iss 1, Pp 33-40 (1994)
Mediators of Inflammation, 3, 33-40.
Mediators of Inflammation
Mediators of Inflammation 3 (1994)

A murine model for acute lethal graftvs. host disease (GVHD) was used to study the role that a number of cytokines play in the development of lethal GVHD. In this study we focused on the role of IL-1, IL-2, IL-4, IL-6, IFN-γand TNF-α. Lethally irra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8295c9e27e33f23a3144a450e6a0aa
https://doaj.org/article/d38c39f78ef54b509299f730e6aee1ef

Fc receptor binding of anti-CD3 monoclonal antibodies is not essential for immunosuppression, but triggers cytokine-related side effects

Autor: Robbert Benner, Ann C. T. M. Vossen, M.J. Kroos, G. J. M. Tibbe, J. G. J. Van De Winkel, Huub F. J. Savelkoul

Publikováno v: European journal of immunology, 25(6), 1492-1496
European journal of immunology 25 (1995) 6

A major drawback to the use of OKT3, a mouse anti-CD3 monoclonal antibody (mAb), as an immunosuppressive agent is the associated cytokine release syndrome. We used a mouse model to elucidate the properties of anti-CD3 mAb responsible for these cytoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0784cf6c85cac619e0a41e7d4dcd4a87
https://pubmed.ncbi.nlm.nih.gov/7614975