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Transcriptomic Analysis Reveals the MicroRNAs Responsible for Liver Regeneration Associated With Mortality in Alcohol-Associated Hepatitis

Autor: Suthat Liangpunsakul, Yanchao Jiang, Ting Zhang, Jing Ma, Patrick S. Kamath, Arun J. Sanyal, Svetlana Radaeva, Zhaoli Sun, Nazmul Huda, Brandon J. Peiffer, Qing Tang, Naga Chalasani, G. J. Gores, Zhihong Yang, Praveen Kusumanchi, Vijay H. Shah

Publikováno v: Hepatology

Background and aims We conducted a comprehensive serum transcriptomic analysis to explore the roles of microRNAs (miRNAs) in alcohol-associated hepatitis (AH) pathogenesis and their prognostic significance. Approach and results Serum miRNA profiling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa219ea01e1b026f70420b583aca1f76
https://pubmed.ncbi.nlm.nih.gov/34096637

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Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis

Autor: Lewis R. Roberts, David M. Kurtz, Scott J. Schoenleber, G. J. Gores, Jayant A. Talwalkar

Publikováno v: British Journal of Cancer

Hepatocellular carcinoma (HCC) is a highly vascular tumour that expresses vascular endothelial growth factor (VEGF). Various studies have evaluated the prognostic value of VEGF levels in HCC. Its overall test performance remains unclear, however. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0aa38ddc4811b95e2408c5417f8258
https://doi.org/10.1038/sj.bjc.6605017

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The Human Immunodeficiency Virus Type 1 Tat Protein Enhances Cryptosporidium parvum -Induced Apoptosis in Cholangiocytes via a Fas Ligand-Dependent Mechanism

Autor: G. J. Gores, Nicholas F. LaRusso, Steven P. O'Hara, Xian Ming Chen, Aaron J. Small, Jeremy B. Nelson, Andrew D. Badley

Publikováno v: Infection and Immunity. 75:684-696

While Cryptosporidium parvum infection of the intestine has been reported in both immunocompetent and immunocompromised individuals, biliary infection is seen primarily in adult AIDS patients and is associated with development of AIDS cholangiopathy.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0713fce274cb67a9f6d9086f667e87a9
https://doi.org/10.1128/iai.01348-06

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Death by association: BH3 domain-only proteins and liver injury

Autor: G. J. Gores, Edwina S. Baskin-Bey

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 289:G987-G990

Apoptosis, a prominent form of cell death, is a prime feature of many acute and chronic liver diseases. Apoptosis requires mitochondrial dysfunction, which is regulated by proteins of the Bcl-2 family. Whether or not a cell should live or die is cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37b132082e258a86f2f4a137f07852a
https://doi.org/10.1152/ajpgi.00371.2005

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Phase II Study of the Efficacy and Safety of Cisplatin-Epinephrine Injectable Gel Administered to Patients With Unresectable Hepatocellular Carcinoma

Autor: Philip J. Johnson, M. Giovannini, T. J. Vogl, G. J. Gores, J. O'Grady, J. Geschwind, K. Engelmann, Simon C.H. Yu, E. K. Orenberg, M. Heneghan, M. Stewart, P. J. Thuluvath, Thomas W.T. Leung

Publikováno v: Journal of Clinical Oncology. 21:652-658

Purpose: To study the efficacy and safety of percutaneous cisplatin-epinephrine (CDDP-EPI) injectable gel in patients with localized unresectable hepatocellular carcinoma (HCC). Patients and Methods: Eligible patients had histologically proven HCC, n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46daa4780403ef00cb6be82599849f53
https://doi.org/10.1200/jco.2003.04.152

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Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C

Autor: R. T. Stravitz, Y. P. Rao, Blake Jones, G. J. Gores

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 272:G1109-G1115

Toxic bile salts induce hepatocyte apoptosis, a model relevant to liver injury during cholestasis. However, the signaling mechanisms culminating in bile salt-induced apoptosis remain unclear. Because protein kinase C (PKC) is activated by bile salts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d413fd080bd569adc4c14b331bbdd885
https://doi.org/10.1152/ajpgi.1997.272.5.g1109

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