Výsledky vyhledávání - "G. J. Durant"

Structures of nine histamine H2 antagonists related to N-cyano-N'-methyl-N'-[4-(2-pyridyl)butyl]guanidine

Autor: David J. Watkin, Keith Prout, G. J. Durant, D. G. Cooper, Ch R Ganellin, K. Burns, G. S. Sach

Publikováno v: Acta Crystallographica Section B Structural Science. 49:547-559

The crystal and molecular structures of the following compounds showing histamine H2-antagonist activity have been determined: (1) N-Cyano-N'-methyl-N"-12[(2-pyridyl)methylthi_'o]ethyl } guanidine, C 11H 15 N5 S, Mr = 249.33, triclinic, P1, a = 7.482

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cd0f8d47f2e75a28e25c8a162f6bdb7
https://doi.org/10.1107/s0108768193000217

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Some theoretical aspects on morphology development in seeded composite latexes. I. Batch conditions below monomer saturation

Autor: Y. G. J. Durant, Jean Guillot

Publikováno v: Colloid & Polymer Science. 271:607-615

In seeded emulsion polymerization, during the second stage, new interfaces appear and the surface area changes. A thermodynamic equilibrium approach is presented which predicts particle morphology of a whole range of non-spherical particles upon poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d60083e17d9bd12ea1566298e6f66533
https://doi.org/10.1007/bf00657992

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ChemInform Abstract: Structure of Oxmetidine Dihydrochloride (SKF 92994)

Autor: K. Burns, G. J. Durant, David J. Watkin, T. H. Brown, Keith Prout

Publikováno v: ChemInform. 24

5-(1,3-Benzodioxol-5-ylmethyl)-2-[2-(5-methyl-1H-imidazol-4-ylmethylthio)ethylamino]-4(1H)-pyrimidone dihydrochloride C 19 H 23 N 5 O 3 S 2+ .2Cl - , M r =472.4, triclinic, P1l, a=8.291 (2), b=10.759 (3), c=13.169 (3) A, α=108.42 (2), β=93.28 (2),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92a51e060609099c045a7a28982b6ca5
https://doi.org/10.1002/chin.199316047

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Structure of oxmetidine dihydrochloride (SKF 92994)

Autor: Keith Prout, T. H. Brown, K. Burns, David J. Watkin, G. J. Durant

Publikováno v: Acta Crystallographica Section C Crystal Structure Communications. 49:44-46

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8d0c1da74215f171a2386314f3b951b
https://doi.org/10.1107/s0108270192003548

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The pharmacology of cimetidine, a new histamine H2-receptor antagonist

Autor: G. J. Durant, R W Brimblecombe, J W Black, Michael E. Parsons, Charon R. Ganellin, W. A. M. Duncan

Publikováno v: British Journal of Pharmacology. 160:S52-S53

Burimamide and metiamide which have been described previously (Black, Duncan, Durant, Ganellin & Parsons, 1972; Black, Duncan, Emmett, Ganellin, Hesselbo, Parsons & Wyllie, 1973) are histamine H2-receptor antagonists. This communication describes som

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49842e38e7b379387b96123b07fafd2b
https://doi.org/10.1111/j.1476-5381.2010.00854.x

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Pharmacological characterization of GT-2016, a non-thiourea-containing histamine H3 receptor antagonist: in vitro and in vivo studies

Autor: C E, Tedford, S L, Yates, G P, Pawlowski, J W, Nalwalk, L B, Hough, M A, Khan, J G, Phillips, G J, Durant, R C, Frederickson

Publikováno v: The Journal of pharmacology and experimental therapeutics. 275(2)

GT-2016, a non-thiourea-containing imidazole, has been developed as a histamine H3 antagonist. In vitro and in vivo studies in rats were conducted to characterize receptor selectivity and autoreceptor functionality for GT-2016. GT-2016 demonstrated h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::777045529743ae4834ede59cca29f7b2
https://pubmed.ncbi.nlm.nih.gov/7473144

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