Zobrazeno 1 - 10
of 44
pro vyhledávání: '"G. J. Allen"'
Publikováno v:
Clinical Genetics. 30:466-470
The case is reported of a child with the karyotype 46,XY,r(21), who presented with linear growth retardation but who appears, at age 2 years 8 months, to be developing normally mentally. There is a small number of reports of mildly affected cases of
Autor:
T. G. J. Allen
Publikováno v:
Nature Protocols. 1:2543-2550
Micro-island cultures provide a simplified system for studying the expression of cellular phenotype, excitability, synapse formation and pre- and postsynaptic regulatory mechanisms without the usual problems that arise from complex interactions betwe
Publikováno v:
The Journal of Neuroscience. 26:1588-1595
Basal forebrain (BF) neurons provide the principal cholinergic drive to the hippocampus and cortex. Their degeneration is associated with the cognitive defects of Alzheimer’s disease. Immunohistochemical studies suggest that some of these neurons c
Autor:
David Brown, T. G. J. Allen
Publikováno v:
The Journal of Physiology. 554:353-370
The expression of ATP-sensitive K+ (KATP) channels by magnocellular cholinergic basal forebrain (BF) neurones was investigated in thin brain slice and dissociated cell culture preparations using a combination of whole-cell, perforated-patch and singl
Autor:
T. G. J. Allen
Publikováno v:
The Journal of Physiology. 515:93-107
The Ca2+ channel subtypes controlling ACh release from basal forebrain neurones and the ionic basis underlying muscarinic receptor-mediated autoinhibition were studied using skeletal myoballs to detect ACh release from individual rat basal forebrain
Autor:
D. Jack Waters, T. G. J. Allen
Publikováno v:
The Journal of Physiology. 508:453-469
1. Ionotropic glutamate receptor-mediated responses were recorded from rat magnocellular basal forebrain neurones under voltage clamp from a somatically located patch-clamp pipette. Currents were recorded from both acutely dissociated neurones and ne
Autor:
Noel J. Buckley, David Brown, T. G. J. Allen, Fe C. Abogadie, Jane E. Haley, A A Selyanko, P Delmas, J.A. Lamas, M.P. Caulfield
Publikováno v:
Life Sciences. 60:1137-1144
The receptor subtype and transduction mechanisms involved in the regulation of various neuronal ionic currents are reviewed, with some recent observations on sympathetic neurons, hippocampal cell membranes and basal forebrain cells.
Autor:
Geoffrey Burnstock, T. G. J. Allen
Publikováno v:
British Journal of Pharmacology. 100:261-268
1. The actions of gamma-aminobutyric acid (GABA) on the intramural neurones of 14-18 day old rats were studied in situ by use of intracellular current- and voltage-clamp techniques. The ionic conductance changes and the effects of various GABA-recept
Autor:
Geoffrey Burnstock, T. G. J. Allen
Publikováno v:
The Journal of Physiology. 422:463-480
1. The effects of muscarine upon intracardiac neurones cultured from ganglia within the atria and interatrial septum of the newborn guinea-pig heart were studied using intracellular recording techniques. 2. Muscarine applied to the neuronal soma typi
Autor:
T G J, Allen, D A, Brown
Publikováno v:
The Journal of physiology. 554(Pt 2)
The expression of ATP-sensitive K(+) (K(ATP)) channels by magnocellular cholinergic basal forebrain (BF) neurones was investigated in thin brain slice and dissociated cell culture preparations using a combination of whole-cell, perforated-patch and s