Výsledky vyhledávání - "G. J. A. M. Strous"

The ubiquitin-proteasome pathway regulates lysosomal degradation of the growth hormone receptor and its ligand

Autor: P van Kerkhof, G. J. A. M. Strous

Publikováno v: Biochemical Society Transactions. 29:488-493

The growth hormone (GH) receptor (GHR) is a mammalian plasma membrane protein whose internalization is mediated by the ubiquitin-proteasome pathway. GH internalization and degradation are inhibited when cells are treated with proteasome inhibitors. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d598e702f4b69f7dd6d1f0e1cbfae72
https://doi.org/10.1042/bst0290488

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Mouse hepatitis virus strain A59 is released from opposite sides of different epithelial cell types

Autor: G. J. A. M. Strous, Marian C. Horzinek, John W. A. Rossen, Peter J. M. Rottier

Publikováno v: Journal of General Virology. 78:61-69

Coronaviruses infect humans and animals through epithelial cells of the gastrointestinal and respiratory tracts that serve as their primary target. When studying infections in cultured polarized epithelial cells, we found previously that coronaviruse

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https://doi.org/10.1099/0022-1317-78-1-61

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Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains

Autor: L van Rens, Leo W. J. Klomp, G. J. A. M. Strous

Publikováno v: Biochemical Journal. 308:831-838

Human gastric mucin was isolated by successive CsCl-gradient ultracentrifugation in the presence of guanidinium hydrochloride to prevent degradation of the polypeptide moieties of the molecules. The amino acid sequence of a tryptic fragment of this m

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https://doi.org/10.1042/bj3080831

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MHV-A59 Enters Polarized Murine Epithelial Cells through the Apical Surface but Is Released Basolaterally

Autor: G. J. A. M. Strous, M.C. Horzinek, A van der Ende, John W. A. Rossen, P. J. M. Rottier, W. F. Voorhout

Publikováno v: Virology, 210(1), 54-66. Academic Press Inc.
Virology, 210(1), 54. Academic Press
Virology
Virology, 210(1), 54-66. ACADEMIC PRESS INC ELSEVIER SCIENCE

Coronaviruses have a marked tropism for epithelial cells. Entry and release of the porcine transmissible gastroenteritis virus (TGEV) is restricted to apical surfaces of polarized epithelial cells, as we have recently shown (J. W. A. Rossen, C. P. J.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc24106a559aa9ad5781b3e8e8f496b
https://doi.org/10.1006/viro.1995.1316

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Identification of a human gastric mucin precursor: N-linked glycosylation and oligomerization

Autor: Leo W. J. Klomp, L van Rens, G. J. A. M. Strous

Publikováno v: Biochemical Journal. 304:693-698

Gastric mucin plays an important role in the protection of the stomach wall from chemical, microbiological and mechanical damage. We have previously isolated human gastric mucus glycoproteins and raised a polyclonal antiserum against these macromolec

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https://doi.org/10.1042/bj3040693

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Biosynthesis of a human gall-bladder mucin

Autor: Leo W. J. Klomp, A J de Lely, G. J. A. M. Strous

Publikováno v: Biochemical Journal. 304:737-744

Mucin glycoproteins play an important role in the initial stages of gall-stone formation by a currently largely unknown mechanism. Understanding the structure of gall-bladder mucin is necessary to comprehend the mechanism by which cholesterol monohyd

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https://doi.org/10.1042/bj3040737

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Entry and release of transmissible gastroenteritis coronavirus are restricted to apical surfaces of polarized epithelial cells

Autor: W. F. Voorhout, A van der Ende, Cornelis P. J. Bekker, John W. A. Rossen, G. J. A. M. Strous, P. J. M. Rottier

Publikováno v: Europe PubMed Central

The transmissible gastroenteritis coronavirus (TGEV) infects the epithelial cells of the intestinal tract of pigs, resulting in a high mortality rate in piglets. This study shows the interaction of TGEV with a porcine epithelial cell line. To determi

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https://doi.org/10.1128/jvi.68.12.7966-7973.1994

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Expression of functional growth hormone receptor in a mouse L cell line infected with recombinant vaccinia virus

Autor: G. J. A. M. Strous, J W Slot, C. Verheijen, P van Kerkhof, Alan L. Schwartz, John W. A. Rossen, Corne A. M. Roelen, Willisa Liou

Publikováno v: Experimental Cell Research, 211(2), 353-9. HANLEY & BELFUS-ELSEVIER INC

The growth hormone receptor is a member of a large family of receptors including the receptors for prolactin and interleukins. Upon binding to one molecule of growth hormone two growth hormone receptor polypeptides dimerize. We have expressed the rab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb85f1a3d64dbd66f3b7941ab29e193a
https://research.rug.nl/en/publications/c7417580-05cc-40a6-91f9-174fcd6b8db8

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Bidirectional transcytosis determines the steady state distribution of the transferrin receptor at opposite plasma membrane domains of BeWo cells

Autor: A van der Ende, G. J. A. M. Strous, D P Cerneus

Publikováno v: The Journal of Cell Biology
Journal of cell biology, 122(6), 1223-1230. Rockefeller University Press

Trophoblast-like BeWo cells form well-polarized epithelial monolayers, when cultured on permeable supports. Contrary to other polarized cell systems, in which the transferrin receptor is found predominantly on the basolateral cell surface, BeWo cells

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https://doi.org/10.1083/jcb.122.6.1223

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Identification of subcellular compartments involved in biosynthetic processing of cathepsin D

Autor: S. Rijnboutt, G. J. A. M. Strous, Hans J. Geuze, Willem Stoorvogel

Publikováno v: Journal of Biological Chemistry. 267:15665-15672

We have assigned the biosynthetic processing steps of cathepsin D to intracellular compartments which are involved in its transport to lysosomes in HepG2 cells. Cathepsin D was synthesized as a 51-kDa proenzyme. After formation of 51-55-kDa intermedi

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https://doi.org/10.1016/s0021-9258(19)49587-2

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