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pro vyhledávání: '"G. I. Abelev"'
Autor:
G. I. Abelev
Publikováno v:
Russian Journal of Developmental Biology. 37:187-192
The role of mechanisms underlying differentiation is considered in malignant transformation of hemoblastoses and epithelial tumors. In hemoblastoses, differentiation is intimately related to malignant transformation and they are underlain by the same
Autor:
G. I. Abelev
Publikováno v:
Molecular Biology. 37:2-8
The data considered in the paper indicate that a tumor clone resulting from cell transformation, in order to develop into an overt neoplasm, should overcome a microenvironmental constraint. This destroys intercellular contacts and cell interactions w
Autor:
T. L. Eraiser, G. I. Abelev, N. L. Lazarevich, V. S. Poltoranina, E.R. Karamova, A. K. Yazova, L. Ya. Shipova, N. I. Kuprina
Publikováno v:
International Journal of Cancer. 75:371-378
The rat hepatoma cell line McA RH7777 was cloned into alpha-fetoprotein-producing (AFP+) and non-producing (AFP-) sublines. A monoclonal antibody (MAb A2/3) reacting with an antigen (Ag A2/3) present only in AFP- clones or AFP- cells in mixed clones
Autor:
N. I. Kuprina, T. L. Eraizer, G. I. Abelev, L. Ya. Shipova, A. B. Lunkina, V. S. Poltoranina, A. K. Yazova, N. L. Lazarevich
Publikováno v:
Bulletin of Experimental Biology and Medicine. 122:1115-1119
Rat hepatoma cell line McA Rh 7777 produces α-fetoprotein (AFP)in vitro. This line is subcloned into ATP-producing and nonproducing subclones. The AFP-negative clone is used to generate hybridomas producing monoclonal antibodies recognizing AFT− a
Publikováno v:
Immunology Letters. 40:133-138
Electrochromatography (ECHR) exploits a very high electro-osmotic counterflow developed in porous membranes at discontinuous electrophoresis. This counterflow exceeds considerably the anodic migration of any negatively charged protein and is used as
Autor:
G I, Abelev
Publikováno v:
Ontogenez. 37(3)
The role of mechanisms underlying differentiation is considered in malignant transformation of hemoblastoses and epithelial tumors. In hemoblastoses, differentiation is intimately related to malignant transformation and they are underlain by the same
Autor:
G I, Abelev
Publikováno v:
Molekuliarnaia biologiia. 37(1)
The data considered in the paper indicate that a tumor clone resulting from cell transformation, in order to develop, should overcome a microenvironmental constraint. This destroys intercellular contacts and cell interactions with extracellular matri
Autor:
G I, Abelev
Publikováno v:
Vestnik Rossiiskoi akademii meditsinskikh nauk. (9)
The paper gives a historical overview of the origin and experimental analysis of alpha-fetoprotein (AFP) regulation and its reexpression in malignant tumors. It shows how a specific hepatoma-specific antigen that was later identified as the major pro
Publikováno v:
Biochemistry. Biokhimiia. 66(5)
The epitope structure of human alpha-fetoprotein (AFP) was studied using more than 50 monoclonal antibodies (MAB) to human AFP. These MAB obtained from various world laboratories of the TD-2 AFP Workshops of the International Society for Oncodevelopm
Autor:
G I, Abelev
Publikováno v:
Biochemistry. Biokhimiia. 65(1)
This review considers the relationship between differentiation mechanisms and the genesis and maintenance of tumor phenotype. To a certain extent, carcinomas preserve differentiation markers of normal tissue, and hemoblastoses precisely reflect the d