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The BET degrader ZBC260 suppresses stemness and tumorigenesis and promotes differentiation in triple-negative breast cancer by disrupting inflammatory signaling

Autor: Deeksha Sharma, Cody G. Hager, Li Shang, Lam Tran, Yongyou Zhu, Aihui Ma, Brian Magnuson, Matthew W. Lesko, Max S. Wicha, Monika L. Burness

Publikováno v: Breast Cancer Research, Vol 25, Iss 1, Pp 1-17 (2023)

Abstract Background Breast cancer stem cells (BCSCs) are resistant to standard therapies, facilitate tumor dissemination, and contribute to relapse and progression. Super-enhancers are regulators of stemness, and BET proteins, which are critical for

Externí odkaz: https://doaj.org/article/6f7b31ca863f456889a102d656ed7db6

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Control of waterhemp (Amaranthus tuberculatus) at multiple locations in Illinois with single preemergence applications of VLCFA-inhibiting herbicides

Autor: Seth A. Strom, Kip E. Jacobs, Nicholas J. Seiter, Adam S. Davis, Dean E. Riechers, Aaron G. Hager

Publikováno v: Weed Technology. 36:253-260

Herbicides that inhibit very-long-chain fatty acids (VLCFAs) have been widely used for preemergence control of annual monocot and small-seeded dicot weed species, such as waterhemp, since their discovery in the 1950s. VLCFA-inhibiting herbicides are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43416201820fcfdf3a9874645999b8a9
https://doi.org/10.1017/wet.2022.1

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Significance of application timing, formulation, and cytochrome P450 genotypic class on sweet corn response to dicamba

Autor: Christopher A. Landau, Mark L. Bernards, Aaron G. Hager, Martin M. Williams

Publikováno v: Weed Science. 70:167-173

Sweet corn (Zea mays L.) tolerance to dicamba and several other herbicides is due to cytochrome P450 (CYP)-mediated metabolism and is conferred by a single gene (Nsf1). Tolerance varies by CYP genotypic class, with hybrids homozygous for functional C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1588f83e0198c8517cdd329e9f180a3d
https://doi.org/10.1017/wsc.2022.5

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Characterization and inheritance of dicamba resistance in a multiple-resistant waterhemp (Amaranthus tuberculatus) population from Illinois

Autor: Darci A Giacominni, Aaron G. Hager, Lucas K. Bobadilla, Patrick J. Tranel

Publikováno v: Weed Science. 70:4-13

Waterhemp [Amaranthus tuberculatus (Moq.) Sauer] is one of the most troublesome agronomic weeds in the midwestern United States. The rapid evolution and selection of herbicide-resistance traits in A. tuberculatus is a major challenge in managing this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ffd6ecf9699e09ebc5b7598f36019ca
https://doi.org/10.1017/wsc.2021.76

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Diminishing weed control exacerbates maize yield loss to adverse weather

Autor: Aaron G. Hager, Christopher A. Landau, Martin M. Williams

Publikováno v: Global Change Biology. 27:6156-6165

Both weed interference and adverse weather can cause significant maize yield losses. However, most climate change projections on maize yields ignore the fact that weeds are widespread in maize production. Herein, we examine the effects of weed contro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec89f8c1c733b409ae1a214ab173dde
https://doi.org/10.1111/gcb.15857

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Metabolic Pathways forS-Metolachlor Detoxification Differ Between Tolerant Corn and Multiple-Resistant Waterhemp

Autor: Nicholas J Seiter, Seth A. Strom, Aaron G. Hager, Jeanaflor Crystal T. Concepcion, Shiv S. Kaundun, James Morris, Adam S. Davis, Dean E. Riechers

Publikováno v: Plant and Cell Physiology

Herbicide resistance in weeds can be conferred by target-site and/or non-target-site mechanisms, such as rapid metabolic detoxification. Resistance to the very-long-chain fatty acid–inhibiting herbicide, S-metolachlor, in multiple herbicide-resista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168d191ac6d1b90137511ef423b4e110
https://doi.org/10.1093/pcp/pcab132

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Virtual estimation of effective dose in neutron fields

Autor: Richard Tanner, Jonathan Eakins, Pasquale Lombardo, Filip Vanhavere, O. van Hoey, Mahmoud Eid Mahmoud Abdelrahman, Jan T M Jansen, L. G. Hager, E. Kouroukla

Publikováno v: Journal of Radiological Protection. 41:360-383

The PODIUM project aims to provide real-time assessments of occupationally exposed workers by tracking their motion and combining this with a simulation of the radiation field. The present work describes the approach that would be taken in mixed neut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca2ef5a4e74a97c695d5f4895370020
https://doi.org/10.1088/1361-6498/abf3b0

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