Výsledky vyhledávání - "G. H. Reaman"

Developmental therapeutics in childhood cancer. A perspective from the Children's Oncology Group and the US Food and Drug Administration

Autor: M L, Bernstein, G H, Reaman, S, Hirschfeld

Publikováno v: Hematology/oncology clinics of North America. 15(4)

Drug development in pediatric oncology has been reviewed, concentrating on overall development issues and COG studies of cytotoxic compounds. A variety of interesting molecules with more specific targeting are becoming available. The challenges that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7aae66807c8774893dcb2798f557a2af
https://pubmed.ncbi.nlm.nih.gov/11676277

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A phase I trial and pharmacokinetic study of 9-cis-retinoic acid (ALRT1057) in pediatric patients with refractory cancer: a joint Pediatric Oncology Branch, National Cancer Institute, and Children's Cancer Group study

Autor: P C, Adamson, B C, Widemann, G H, Reaman, N L, Seibel, R F, Murphy, A F, Gillespie, F M, Balis

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(10)

To determine the maximum tolerated dose and describe the toxicities of 9-cis-retinoic acid (9cRA, ALRT1057) administered p.o. tid in pediatric patients with refractory cancer and to study the pharmacokinetics of 9cRA and determine whether systemic dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74923cc529c68eeee4d8ba593858b3ba
https://pubmed.ncbi.nlm.nih.gov/11595682

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Pet ownership and childhood acute leukemia (USA and Canada)

Autor: A R, Swensen, J A, Ross, X O, Shu, G H, Reaman, M, Steinbuch, L L, Robison

Publikováno v: Cancer causescontrol : CCC. 12(4)

For more than three decades there has been speculation regarding a possible role of zoonotic diseases in the development of human leukemia. This study investigated the potential relationship between exposure to pets and the development of childhood l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9609959e607dad0417afcd3fed6381aa
https://pubmed.ncbi.nlm.nih.gov/11456225

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INK4A/ARF deletions are acquired at relapse in childhood acute lymphoblastic leukaemia: a paired study on 25 patients using real-time polymerase chain reaction

Autor: T L, Carter, G H, Reaman, U R, Kees

Publikováno v: British journal of haematology. 113(2)

Current risk-adjusted intensive therapies for childhood acute lymphoblastic leukaemia (ALL) are expected to result in an event-free survival of greater than 75%. In sharp contrast, relapsed paediatric ALL is a difficult disease to treat. In this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03e14837ba59103c9f1f446fe8f4dae5
https://pubmed.ncbi.nlm.nih.gov/11380395

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Phase I study of CI-958 in children and adolescents with recurrent solid tumors

Autor: C A, Arndt, M D, Krailo, W, Liu-Mares, P M, Anderson, G H, Reaman

Publikováno v: Cancer. 91(6)

CI-958 is a synthetic intercalating agent of a new chemical class, the benzopyranoindazoles, with promising preclinical activity. Its mechanism of action is thought to be stabilization of the cleavable complex of DNA with topoisomerase II, as well as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88b285277103f01d6cef61e9ad64af15
https://pubmed.ncbi.nlm.nih.gov/11267962

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A phase I clinical, pharmacological, and biological trial of interleukin 6 plus granulocyte-colony stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent/refractory solid tumors: enhanced hematological responses but a high incidence of grade III/IV constitutional toxicities

Autor: F, Bracho, M D, Krailo, V, Shen, S, Bergeron, V, Davenport, W, Liu-Mares, B R, Blazar, A, Panoskaltsis-Mortari, C, van de Ven, R, Secola, M M, Ames, J M, Reid, G H, Reaman, M S, Cairo

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(1)

A Phase I trial was conducted to determine the safety, biological activity, and hematopoietic recovery by the combination of interleukin 6 (IL-6) and granulocyte-colony stimulating factor (G-CSF) after myelosuppressive chemotherapy in children. Patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::291872cd83c5c9892813844de2a17516
https://pubmed.ncbi.nlm.nih.gov/11205919

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Intracranial calcifications in childhood medulloblastoma: relation to nevoid basal cell carcinoma syndrome

Autor: T, Stavrou, E C, Dubovsky, G H, Reaman, A M, Goldstein, G, Vezina

Publikováno v: AJNR Am J Neuroradiol

BACKGROUND AND PURPOSE: Medulloblastoma is one of the most common posterior fossa tumors to occur in children. Our purpose was to document the frequency, location, and time of occurrence of intracranial calcifications in cranial CT studies of childre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d6728701f520af4d0905a5836b49261
https://pubmed.ncbi.nlm.nih.gov/10782799

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