Výsledky vyhledávání - "G. H. Rasmusson"

Identification of human cytochrome P450 isozymes responsible for the in vitro oxidative metabolism of finasteride

Autor: S W, Huskey, D C, Dean, R R, Miller, G H, Rasmusson, S H, Chiu

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 23(10)

Finasteride, a prescription drug for the treatment of benign prostatic hypertrophy and alleviation of symptoms associated with benign prostatic hypertrophy and alleviation of symptoms associated with benign prostatic hypertrophy, has been shown to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b20db4fe0452a1d8daa696ca0035502
https://pubmed.ncbi.nlm.nih.gov/8654202

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4-Azasteroidal 5 alpha-reductase inhibitors without affinity for the androgen receptor

Autor: G H Rasmusson, G F Reynolds, A H Cheung, C E Heiss, T Liang

Publikováno v: Journal of Biological Chemistry. 259:734-739

In efforts to develop potent 5 alpha-reductase inhibitors without affinity for the androgen receptor, synthetic 3-oxo-5 alpha-steroids were tested for their ability to inhibit 5 alpha-reductase, using [14C]testosterone as the substrate, and for their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a241aa3c30377847fbd6c2de59659220
https://doi.org/10.1016/s0021-9258(17)43519-8

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Photoaffinity labeling of steroid 5 alpha-reductase of rat liver and prostate microsomes

Autor: G F Reynolds, A H Cheung, T Liang, G H Rasmusson

Publikováno v: Journal of Biological Chemistry. 260:4890-4895

21-Diazo-4-methyl-4-aza-5 alpha-pregnane-3,20-dione (Diazo-MAPD) inhibits steroid 5 alpha-reductase in liver microsomes of female rats with a Ki value of 8.7 +/- 1.7 nM, and the inhibition is competitive with testosterone. It also inhibits the bindin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91ee726bc4cc34ca05d4fade0d3d5aae
https://doi.org/10.1016/s0021-9258(18)89155-4

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Induction of the cortical reaction in hamster eggs by membrane-active agents

Autor: G. H. Rasmusson, D. T. Williams, R. B. L. Gwatkin

Publikováno v: Reproduction. 47:299-303

Fusion of capacitated spermatozoa with the vitelline membrane, but not actual penetration, appears to initiate the cortical reaction in hamster eggs. The reaction can be artificially induced by the application of positively charged particles to the v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99135650cdbac39e6089561327b22544
https://doi.org/10.1530/jrf.0.0470299

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A New Class of 5α-Reductase Inhibitors

Autor: J. R. Brooks, G. H. Rasmusson, T. Liang

Publikováno v: Gene Regulation by Steroid Hormones II ISBN: 9781461254843

Over the past 20 years several approaches to the control of androgen action have been investigated by research teams at Merck & Co., Inc. Basically, these approaches can be described as those that would cause chemical interference at certain critical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d72239737b0f9a09bccfea75a6360d3
https://doi.org/10.1007/978-1-4612-5482-9_19

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Recent Advances in the Biology and Chemistry of Vitamin D

Autor: G. H. Rasmusson, H. Jones

Publikováno v: Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products ISBN: 9783709185537

The D-vitamins are a group of fat soluble materials with high antirachitic activity. Rickets is a disease of infancy caused by faulty calcium hydroxy apatite deposition in the growing bone. It was Palm (140) in 1890 who found that the disease respond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::694527e3a01672651ff8edae382caad7
https://doi.org/10.1007/978-3-7091-8551-3_2

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Recent advances in the biology and chemistry of vitamin D

Autor: H, Jones, G H, Rasmusson

Publikováno v: Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles. 39

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d7457bc28cc1044330cdd0d5c216682d
https://pubmed.ncbi.nlm.nih.gov/6988312

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