Evaluation of various cytostatic drugs as local immunotherapeutic agents

Autor: G. H. Boerrigter, Rik J. Scheper, A. Vos, J. de Groot

Publikováno v: Investigational New Drugs. 2:221-225

The cytostatic drugs methotrexate, 5-fluorouracil, adriamycin, vincristin, cisplatinum, VP-16 and the newly synthesized, stabile cyclophosphamide-derivative Z-7557, were screened for possible immunopotentiating effects in local chemotherapy. With an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91997dedc8643f18a1e903e9405ef851
https://doi.org/10.1007/bf00232355

Eular workshop on Rheumatology Research

Autor: A. Bjelle, B. Cedergren, L. Wählby, A. P. Th. Boerbooms, P. J. Geerdink, L. B. A. van de Putte, F. A. M. Ouweland, R. R. C. Buchanan, A. Morgan, N. A. Staines, P. J. W. Venables, R. N. Maini, R. C. Bucknall, P. A. Bacon, J. Verrier Jones, M. Leirisalo, O. Laitinen, M. Bühring, C. Rosak, W. Stöckle, W. Magnet, L. J. Catogio, R. M. Bernstein, C. M. Black, G. R. V. Hughes, P. J. Maddison, P. J. Charles, Yi. Tung, R. C. Buchanan, H. Deicher, E. Weißbarth, J. Zeller, B. Baruth, F. Delbarre, A. de Gery, A. Kahan, E. de Vries, C. J. P. van der Veen, J. P. van der Weij, F. Klein, A. M. de Bruijn, A. Cats, R. Dreher, null Coworkers, M. Duclos, H. Peter, H. Zeidler, P. Rieber, J. Pichler, W. Limany, N. Dunn, N. P. Hurst, E. Denholm, G. Nuki, A. Ebringer, J. Hayes, P. Cowling, R. Ebringer, T. Egeland, Ø. Forre, J. J. M. Festen, F. H. Kuipers, A. H. Schaars, Ø. Førre, K. Waalen, O. J. Mellbye, K. Froebel, D. Lewis, R. D. Sturrock, R. Goldschmeding, P. C. Limburg, G. W. Pastoor, P. M. Houtman, C. G. M. Kallenberg, P. Halberg, I. Lorenzen, J. Bennedsen, J. M. Rhodes, N. D. Hall, L. -J. Eales, D. R. Blake, I. M. Hunneyball, K. Helmke, T. Boeder, J. Teuber, P. Hermanns, E. M. Veys, G. Verbruggen, A. C. Horsfall, P. A. Mumford, L. Schrieber, O. Huber, H. Kluin-Nelemans, J. Vernooy, F. Gmelig Meyling, R. Derksen, L. Kater, G. Husby, J. T. Gran, E. Thorsby, G. D. Johnson, D. R. Bainbridge, E. J. Holborow, M. Bubel, D. H. Goddard, J. Jonsson, R. Norberg, W. Schilling, R. Kalden, O. Leitner, B. Manger, A. Beck, B. Koch, M. C. J. M. de Jong, T. Walstra, J. van der Meulen, M. Kávai, A. Bányai, A. Zsindely, I. Sonkoly, Gy. Szegedi, L. Klareskog, U. Forsum, A. Scheynius, D. Kabelitz, H. Wigzell, P. Koivuranta, H. Repo, U. Kiistala, P. Österman, Y. Konttinen, C. Friman, E. Tolvanen, E. Johansson, Y. T. Konttinen, S. Reitamo, A. Seppä, M. Malmström, F. Lindström, H. Hellquist, J. Olofsson, PJ. Maddison, CM. Black, MIV Jayson, J. R. Batchelor, Kl. Walsh, RM Bernstein, LJ. Catoggio, CD. Holland, GRV Hughes, J. M. Mbuyi, J. Dequeker, Ö Förre, W. Johnsen, C. J. L. M. Meijer, C. de Graaf-Reitsma, G. J. M. Lafeber, O. Meyer, O. Borda-Oriarte, T. Haïm, A. Ryckewaert, H. Mielants, M. Van Steenkiste, J. De Langhe, M. Moutsopoulos, J. Hooks, P. Mumford, V. Patel, G. S. Panayi, D. Piatier-Tonneau, P. S. Mach, C. Plater-Zyberk, M. Clarke, F. Raeman, W. De Cock, J. Leempoels, J. De Cree, H. Verhaegen, A. Ranki, T. Paavonen, U. Kankaanpää, E. Nilsson, G. Biberfeld, G. Room, J. G. Saal, F. Frank, H. Rauteenstrauch, M. Hadam, P. Fritz, W. Laschner, R. J. Scheper, B. M. E. von Blomberg-van der Flier, G. H. Boerrigter, D. van Bruynzeel, A. C. H. M. van Dinther-Janssen, K. H. Simon, R. E. Schmidt, C. C. Erhardt, R. D. Melsom, J. McCarthy, R. Smeenk, G. Van der Lelij, L. Aarden, N. D. Staite, H. E. Stierle, K. A. Brown, J. D. Perry, A. J. G. Swaak, J. Groenwold, R. J. T. Smeenk, G. H. Toenes, H. H. Edel, K. Eggert, E. Held, F. K. Hübner, M. Schattenkirchner, O. Wegelius, F. Tron, L. Jacob, J. F. Bach, J. W. Lens, W. B. van den Berg, M. H. van Rijswijk, M. A. van Leeuwen, M. van der Giessen, T. H. The, W. J. van Venrooij, C. A. G. van Eekelen, W. J. A. Habets, M. H. L. Salden, D. J. de Rooij, P. Van Wanghe, Ph. Hermanns, Ph. Van Bruwaene, G. De Brabanter, D. De Landsheere, C. Immesoete, M. J. F. Walravens, E. Stevens, H. Warnatz, G. Lemm, A. Wiik, J. Petersen, H. Permin, F. A. Wollheim, J. Carlsson, A. Forsgren, H. Pettersson, P. Youinou, P. Miossec, P. Le Goff

Publikováno v: Clinical Rheumatology. 1:47-78

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::764ec7190d614550fdb65dcbc253cb72
https://doi.org/10.1007/bf02032477

Potentiation of T-cell-mediated immunity by local chemotherapy

Autor: Rik J. Scheper, J. de Groot, G. H. Boerrigter, A. Vos

Publikováno v: Agents and Actions. 15:77-79

An investigation was made into the effects of local administration of various anti-cancer drugs during contact sensitization on the development of delayed hyper-sensitivity. Low doses of cell-cycle non-specific drugs, particularly some recently synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce13e641bbf2d9b401d1dc8e53f89fef
https://doi.org/10.1007/bf01966974

Local administration of cytostatic drug 4-hydroperoxy-cyclophosphamide (4-HPCY) facilitates cell-mediated immune reactions

Autor: G H, Boerrigter, R J, Scheper

Publikováno v: Clinical and experimental immunology. 58(1)

4-Hydroperoxy-cyclophosphamide (4-HPCY) is a cyclophosphamide (CY) derivative that, unlike CY, does not need liver conversion for its action. This new drug has been recently described to preferentially eliminate suppressor B and T lymphocytes in vitr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee99fc2248e424a9cc291d2e6356cca9
https://pubmed.ncbi.nlm.nih.gov/6478648

Intradermal administration of 4-hydroperoxy-cyclophosphamide during contact sensitization potentiates effector T cell responsiveness in draining lymph nodes

Autor: Rik J. Scheper, Jan Cees de Groot, G. H. Boerrigter

Publikováno v: Immunopharmacology. 11(1)

4-Hydroperoxy-cyclophosphamide (4-HPCY) is an in vitro active form of cyclphosphamide. In a previous study, using an in vivo contact sensitivity model in the guinea pig, we demonstrated that intradermal injection of small amounts (50–200 μg) of 4-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13ac38afda39940d1949da0af59aa75
https://pubmed.ncbi.nlm.nih.gov/3485619