Zobrazeno 1 - 10
of 145
pro vyhledávání: '"G. Gregory Neely"'
Autor:
Sebastien Martinez, Shifei Wu, Michael Geuenich, Ahmad Malik, Ramona Weber, Tristan Woo, Amy Zhang, Gun Ho Jang, Dzana Dervovic, Khalid N. Al-Zahrani, Ricky Tsai, Nassima Fodil, Philippe Gros, Steven Gallinger, G. Gregory Neely, Faiyaz Notta, Ataman Sendoel, Kieran Campbell, Ulrich Elling, Daniel Schramek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Functionally characterizing the genetic alterations that drive pancreatic cancer is a prerequisite for precision medicine. Here, we perform somatic CRISPR/Cas9 mutagenesis screens to assess the transforming potential of 125 recurrently mutat
Externí odkaz:
https://doaj.org/article/9926a074e8ba4892ab72de0b846124d2
Autor:
Alexis Diaz-Vegas, Kristen C. Cooke, Harry B. Cutler, Belinda Yau, Stewart W.C. Masson, Dylan Harney, Oliver K. Fuller, Meg Potter, Søren Madsen, Niamh R. Craw, Yiju Zhang, Cesar L. Moreno, Melkam A. Kebede, G. Gregory Neely, Jacqueline Stöckli, James G. Burchfield, David E. James
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101983- (2024)
Mitochondria facilitate thousands of biochemical reactions, covering a broad spectrum of anabolic and catabolic processes. Here we demonstrate that the adipocyte mitochondrial proteome is markedly altered across multiple models of insulin resistance
Externí odkaz:
https://doaj.org/article/d604aeab742c4b69b1c6b31c83faedfb
Autor:
Lorenzo Ricolfi, Catharina Vendl, Jennifer Bräunig, Matthew D. Taylor, Daniel Hesselson, G. Gregory Neely, Malgorzata Lagisz, Shinichi Nakagawa
Publikováno v:
Environment International, Vol 190, Iss , Pp 108860- (2024)
Background: Per- and polyfluoroalkyl substances (PFAS) are a class of widely used anthropogenic chemicals. Concerns regarding their persistence and potential adverse effects have led to multiple secondary research publications. Here, we aim to assess
Externí odkaz:
https://doaj.org/article/eb4faed9fa14400ba5f516171c1eb235
Autor:
Michael A. Sullivan, Samuel D. Lane, André D. J. McKenzie, Sarah R. Ball, Margaret Sunde, G. Gregory Neely, Cesar L. Moreno, Alexandra Maximova, Eryn L. Werry, Michael Kassiou
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-23 (2024)
Abstract Background Widescale evidence points to the involvement of glia and immune pathways in the progression of Alzheimer’s disease (AD). AD-associated iPSC-derived glial cells show a diverse range of AD-related phenotypic states encompassing cy
Externí odkaz:
https://doaj.org/article/ef7a844245764d02918279afb7d9cfa9
Autor:
Catharina Vendl, Matthew D. Taylor, Jennifer Bräunig, Lorenzo Ricolfi, Radiah Ahmed, Maegan Chin, Matthew J. Gibson, Daniel Hesselson, G. Gregory Neely, Malgorzata Lagisz, Shinichi Nakagawa
Publikováno v:
Ecological Solutions and Evidence, Vol 5, Iss 1, Pp n/a-n/a (2024)
Abstract Per‐ and polyfluoroalkyl substances (PFAS) are a large group of synthetic chemicals that have been in use for over 70 years. Their ubiquitous distribution and harmful effects pose a threat to wildlife worldwide. To provide a comprehensive
Externí odkaz:
https://doaj.org/article/29222177586a42a1a99c4604f61c6cbd
Autor:
Bei Wang, Arabella H. Wan, Yu Xu, Ruo-Xin Zhang, Ben-Chi Zhao, Xin-Yuan Zhao, Yan-Chuan Shi, Xiaolei Zhang, Yongbo Xue, Yong Luo, Yinyue Deng, G. Gregory Neely, Guohui Wan, Qiao-Ping Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The “death cap”, Amanita phalloides, is the world’s most poisonous mushroom, responsible for 90% of mushroom-related fatalities. The most fatal component of the death cap is α-amanitin. Despite its lethal effect, the exact mechanisms
Externí odkaz:
https://doaj.org/article/661b392320124b23b3e5ae286e7a1fce
Autor:
Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R. Israel, Robert J. Ju, Samuel D. Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L. McMahon, Hue N. T. Tran, Yanni K.-Y. Chin, Yifei Zhu, Junyu Liu, Theo Crawford, Saipriyaa Purushothamvasan, Abdella M. Habib, David A. Andersson, Lachlan D. Rash, John N. Wood, Jing Zhao, Samantha J. Stehbens, Mehdi Mobli, Andreas Leffler, Daohua Jiang, James J. Cox, Stephen G. Waxman, Sulayman D. Dib-Hajj, G. Gregory Neely, Thomas Durek, Irina Vetter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the voltage-sensing domains, o
Externí odkaz:
https://doaj.org/article/ef7fee6301d340c5b67edc494cc4b801
Autor:
Samuel D. Robinson, Vanessa Schendel, Christina I. Schroeder, Sarah Moen, Alexander Mueller, Andrew A. Walker, Naomi McKinnon, G. Gregory Neely, Irina Vetter, Glenn F. King, Eivind A. B. Undheim
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background Eusociality is widely considered to evolve through kin selection, where the reproductive success of an individual’s close relative is favored at the expense of its own. High genetic relatedness is thus considered a prerequisite
Externí odkaz:
https://doaj.org/article/d7dcdb11b76c4cd2a50d33482f7f16f4
Autor:
Lipin Loo, Matthew A. Waller, Cesar L. Moreno, Alexander J. Cole, Alberto Ospina Stella, Oltin-Tiberiu Pop, Ann-Kristin Jochum, Omar Hasan Ali, Christopher E. Denes, Zina Hamoudi, Felicity Chung, Anupriya Aggarwal, Jason K. K. Low, Karishma Patel, Rezwan Siddiquee, Taeyoung Kang, Suresh Mathivanan, Joel P. Mackay, Wolfram Jochum, Lukas Flatz, Daniel Hesselson, Stuart Turville, G. Gregory Neely
Publikováno v:
PLoS Biology, Vol 21, Iss 2 (2023)
Although ACE2 is the primary receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, a systematic assessment of host factors that regulate binding to SARS-CoV-2 spike protein has not been described. Here, we use whole-gen
Externí odkaz:
https://doaj.org/article/b23da8ae80bf4c039eff72357ad89c27
Autor:
Benjamin McLean, Aji Istadi, Teleri Clack, Mezzalina Vankan, Daniel Schramek, G. Gregory Neely, Marina Pajic
Publikováno v:
Advanced Genetics, Vol 3, Iss 4, Pp n/a-n/a (2022)
Abstract Cancer is the second leading cause of death globally, with therapeutic resistance being a major cause of treatment failure in the clinic. The dynamic signaling that occurs between tumor cells and the diverse cells of the surrounding tumor mi
Externí odkaz:
https://doaj.org/article/e8fa96f16d2e4be4886dbbaf99141bf5