Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

Autor: Jay M. Sosenko, D. J. Becker, Kevan C. Herold, E. Leschek, James W. Thomas, Francesco Dotta, Jeffrey L. Mahon, K. Nanto-Salonen, Diane K. Wherrett, Lisa M. Spain, Andrew Muir, Polly J. Bingley, Massimo Trucco, Jeffrey P. Krischer, S. E. Gitelman, Alessandra Mandelli, Mark S. Anderson, Sarah J. Richardson, Peter S. Linsley, Riccardo Bonfanti, Eleonora Bianconi, George S. Eisenbarth, M. Siegelman, J. Peyman, Angela Stabilini, M. Redondo, Bernhard J. Hering, Richard A. Insel, Maurizio De Pellegrin, Franco Meschi, Francesca Ragogna, Mark A. Clements, Lars Krogvold, Mark Peakman, Alberto Pugliese, J. Blum, William E. Russell, P. Chase, Pia Leete, Anette-Gabriele Ziegler, Mark A. Atkinson, Jane H. Buckner, Andrea Rigamonti, Tihamer Orban, Laura Nigi, Philip Raskin, Guido Sebastiani, Louis H. Philipson, Linda A. DiMeglio, Clara Bonura, Manuela Battaglia, Jay S. Skyler, David A. Baidal, Giulio Frontino, Emanuele Bosi, Matthew J. Dufort, Andrea Valle, William E. Winter, Peter A. Gottlieb, C. G. Fathman, Helena Elding Larsson, Robin Goland, Michael J. Clare-Salzler, M. G. Roncarolo, Raphael Clynes, Peter A. Antinozzi, Andrea K. Steck, Mikael Knip, Olli Simell, R. Parkman, Bart O. Roep, Desmond A. Schatz, Henry Rodriguez, Nicola Lo Buono, John M. Wentworth, Andrea Laurenzi, Francesca Mancarella, P. Savage, Jennifer B. Marks, G. Grave, Paola M.V. Rancoita, Federica Vecchio, Åke Lernmark, Darrell M. Wilson, Noel G. Morgan, Thomas W.H. Kay, Francine R. Kaufman, Federica Cugnata, Christophe Benoist, Susan Geyer, Peter G. Colman, Mark D. Pescovitz, Robert S. Sherwin, Gerald T. Nepom, John E. Wagner, Antoinette Moran, Knut Dahl-Jørgensen, Jerry P. Palmer, Kasia Bourcier, Wayne V. Moore, Carla J. Greenbaum, Pauline Grogan

BACKGROUND. Neutrophils and their inflammatory mediators are key pathogenic components in multiple autoimmune diseases, while their role in human type 1 diabetes (T1D), a disease that progresses sequentially through identifiable stages prior to the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee5d8b12a49d70a6a58dc2174c69799

Effects of Insulin in Relatives of Patients with Type 1 Diabetes Mellitus

Autor: W. E. Winter, N. Vega, R. A. Jackson, J. P. Palmer, K. Herold, D. Conboy, F. R. Kaufman, A. Schiffrin, Greenbaum Cj, P. R. Robertson, S. Harris, Desmond A. Schatz, J. Fradkin, J. Wolfsdorf, John M. Lachin, C. Cowie, George S. Eisenbarth, Della Matheson, J. P. Krischer, J. Valenzuela, T. Smith, Jennifer B. Marks, M. McCulloch-Olsen, H. Dickler, Rebecca J. Cook, Jay S. Skyler, J. I. Malone, B. Zinman, A. Zeidler, L. M. Rafkin-Mervis, R. C. Eastman, Darrell M. Wilson, E. Collier, A. T. Ricker, M. Steffes, M. A. Dennis, D. DeMets, N. K. Maclaren, G. Grave, A. Rossini, Lisa Rafkin-Mervis, D. Brown, L. Finney, Anastasios A. Tsiatis, H. P. Chase, D. Cuthbertson, O. B. Crofford, B. Aneju

Publikováno v: New England Journal of Medicine. 346:1685-1691

It is unknown whether insulin therapy can delay or prevent diabetes in nondiabetic relatives of patients with diabetes.In a randomized, controlled, nonblinded clinical trial, we screened 84,228 first-degree and second-degree relatives of patients wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329f6f9008e3e3e03f9c187cd05738a1
https://doi.org/10.1056/nejmoa012350

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A Polarographic Study on Dipyridamole and its Determination in Commercial Tablets

Autor: Tunel, M., Yazan, Y., Do&(g)grave;rukol, D., Atkošar, Z.

Publikováno v: Analytical Letters; October 1991, Vol. 24 Issue: 10 p1837-1846, 10p